Manavi Yadav

Magnetically retrievable silica-based nickel nanocatalyst for Suzuki–Miyaura cross-coupling reaction

A new magnetically recoverable silica-based nickel nanocatalyst was synthesized, characterized and applied for the first time as a catalyst in Suzuki–Miyaura cross-coupling reaction. Excellent catalytic activity, ease of recovery and reusability up to six cycles without appreciable loss of performance make the present protocol beneficial from industrial and environmental viewpoints.

Maghemite‐Copper Nanocomposites: Applications for Ligand‐Free Cross‐Coupling (C−O, C−S, and C−N) Reactions

A magnetically retrievable, efficient, and benign maghemite‐Cu nanocatalyst was synthesized from inexpensive precursors and applied for C−O, C−N, and C−S bond‐formation reactions. The obtained maghemite‐Cu nanocatalyst was characterized by various techniques such as XRD, X‐ray photoelectron spectroscopy, field‐emission gun SEM with energy‐dispersive spectroscopy, atomic absorption spectroscopy, TEM, high‐angle annular dark‐field scanning transmission electron microscopy, FTIR spectroscopy, and Mössbauer spectroscopy. Excellent catalytic activity, ease of recovery, and reusability without a significant loss of yield make the present protocol highly sustainable to deal with industrial and environmental concerns.

A straightforward one-pot synthesis of bioactive N-aryl oxazolidin-2-ones via a highly efficient Fe3O4@SiO2-supported acetate-based butylimidazolium ionic liquid nanocatalyst under metal- and solvent-free conditions

In the present study, we report the fabrication and characterization of novel acetate-based butylimidazolium ionic liquid immobilized silica-coated magnetic nanoparticles (IL-OAc@FSMNP). The synthesized nanocomposite proves its supremacy as an environmentally benign catalyst in the reaction of aniline and its derivatives with ethylene carbonate to form bioactive N-aryl oxazolidin-2-ones under metal-, ligand-, and solvent-free conditions. The catalyst offers excellent assemblies of hydrogen-bond donors and acceptors, which activate the substrates, thereby delivering good-to-excellent product yields with a conversion and selectivity of more than 99%. Additionally, mild reaction conditions, wide substrate scope, effortless catalytic recovery and recyclability of the catalyst up to eight consecutive cycles offer the potential for scale-up in various pharmaceutical applications.

An efficient copper-based magnetic nanocatalyst for the fixation of carbon dioxide at atmospheric pressure

In the last few decades, the emission of carbon dioxide (CO2) in the environment has caused havoc across the globe. One of the most promising strategies for fixation of CO2 is the cycloaddition reaction between epoxides and CO2 to produce cyclic carbonates. For the first time, we have fabricated copper-based magnetic nanocatalyst and have applied for the CO2 fixation. The prepared catalyst was thoroughly characterized using various techniques including XRD, FT-IR, TEM, FE-SEM, XPS, VSM, ICP-OES and elemental mapping. The reactions proceeded at atmospheric pressure, relatively lower temperature, short reaction time, solvent- less and organic halide free reaction conditions. Additionally, the ease of recovery through an external magnet, reusability of the catalyst and excellent yields of the obtained cyclic carbonates make the present protocol practical and sustainable.

Chapter 8. New Directions from Academia

Past decades have witnessed remarkable advancements in the field of drug discovery and development as a result of the translational research interaction across industry and academia, with many drugs being discovered due to academia–industry partnerships. Low productivity, increasing research and development costs, a decline in the number of new drug applications approved per year by the US Food and Drug Administration (FDA), dissipating proprietary products and dwindling pipelines have been the driving forces behind industry academia alliances. But are such partnerships mutually beneficial? While academic researchers help pharmaceutical industries tackle the challenges of drug synthesis because of their capability to think outside the box, the industrialists provide an opportunity to the academicians to translate their initial discoveries into new therapeutics. Such mutual benefits have led to the number of deals of this nature growing almost exponentially over the years. However, both fields are facing a very tough challenge in producing environmentally-suitable substitutes for hazardous chemicals. This is due to the enormous growth in chemical manufacturing with inefficient processes leading to unacceptable levels of chemical pollution. Recent legislation has brought a major change in supply chains, yet there is a need to satisfy the demands of a growing population. This can only be realized by industry–academia collaboration to find sustainable solutions through a reassessment of the entire lifecycle of a chemical product, from various resources to its usage and ultimate fate. The present chapter underscores the need, benefits, impediments and keys to such collaborations, with examples of novel drugs and pathways discovered through effective academic–industrial partnering.

Water Quality and Sustainability in India: Challenges and Opportunities

Rapid industrialization, urbanization, and population expansion in India have created a number of environmental problems, water pollution being the major one. This has led to deterioration in both the quality and quantity of surface and groundwater, thereby affecting the net availability of water for consumptive use. Despite numerous steps taken by government and local communities, India continues to be deprived of safe drinking water. Safe water provision and environmental sanitation are critical for protecting the environment, improving health and alleviating poverty, bringing safe hygiene practices to make India a safer place. Therefore there is a tremendous need to create other avenues to fill in gaps in the existing structure. This chapter discusses various challenges and opportunities related to water quality and sustainability in India and emphasizes prioritization according to the needs of the country.Abstract Rapid industrialization, urbanization, and population expansion in India have created a number of environmental problems, water pollution being the major one. This has led to deterioration in both the quality and quantity of surface and groundwater, thereby affecting the net availability of water for consumptive use. Despite numerous steps taken by government and local communities, India continues to be deprived of safe drinking water. Safe water provision and environmental sanitation are critical for protecting the environment, improving health and alleviating poverty, bringing safe hygiene practices to make India a safer place. Therefore there is a tremendous need to create other avenues to fill in gaps in the existing structure. This chapter discusses various challenges and opportunities related to water quality and sustainability in India and emphasizes prioritization according to the needs of the country.