Mangestuti Agil

Chemical Constituents and Bioactivities of Several Indonesian Plants Typically Used in Jamu

This article reviews the chemical constituents and bioactivities of several Indonesian plants typically used in Jamu prescriptions in Indonesia. Jamu is Indonesia traditional medicine: it consists of either a single ingredient or a mixture of several medicinal plants. One plant family always used in Jamu is Zingiberaceae (ginger), such as Curcuma domestica/C. longa, C. xanthorrhizae, C. heyneana, C. zedoaria, C. aeruginosa, Zingiber aromaticum, Alpinia galanga. We also report other commonly used plant families such as Justicia gendarussa and Cassia siamea, whose activities have been extensively explored by our department.

Extract ethanol of Centella asiatica reduce expression of Mycobacterium tuberculosis antigen on alveolar macrophage from rats lung tssue infected with Mycobacterium tuberculosis

Centella asiatica is a medicinal plant that has been used as a traditional treatment for healing inflammatory processes. Previous studies have shown that the extract of Centella asiatica is able to increase the immune response and can inhibit the growth of Mycobacterium tuberculosis in vitro. The aims of this study were to determine the effect of ethanol extract of Centella asiatica to reduce the expression of antigen of Mycobacterium tuberculosis on alveolar macrophage cells from rat lung tissue infected with Mycobacterium tuberculosis. Twenty-eight male rats were infected with Mycobacterium tuberculosis strain H37 Rv and divided randomly into four groups. Groups 1, 2, and 3 were treated with the ethanol extract of Centella asiatica at 375 mg/kgBW, 750 mg/kgBW and 1500 mg/kgBW, and fourth group was the control group. Examination of Mycobacterium tuberculosis antigen expression using immunohistochemical methods was performed. Analysis of the data using ANOVA (α=0.05). The results showed that there was a significant reduction of Mycobacterium tuberculosis antigen expression in alveolar macrophage in the treated group at 750 mg/kgBW and 1500 mg/kgBW. In conclusion, the ethanol extract Centella asiatica contains active ingredients that have the ability to decrease the expression of Mycobacterium tuberculosis antigen on alveolar macrophages from rat lung tissue infected with Mycobacterium tuberculosis.

Responses of Diabetes Mellitus Patients Who Used Complementary Medicine

Received Sep 10, 2016 Revised Nov 20, 2016 Accepted Nov 26, 2016 Diabetes Mellitus as a chronic disease tend to seek appropriate medical treatment to heal the condition. Health-seek searched can be either medical treatment or Complementary and Alternative Medicine. This study explored deeply on the response of diabetes mellitus patients who visited to Indonesian Traditional Medicine Polyclinic on Regional Public Hospital dr. Soetomo Surabaya in using complementary medicine. This study used qualitative study with phenomenological method approach. The focus of this study was diabetes mellitus patients who use complementary medicine. Nine participants were selected based on purposive sampling method with certain criteria. Data collection used was in-depth interview and field note. Data analysis used thematic content analysis. Determining five themes that correspond with the purpose of study and a new theme. Some themes were psychological response after being diagnosed diabetes mellitus, opinion on the diabetes mellitus disease, complementary medicine usage patterns, reasons, the response after the use of complementary medicine, and family support. As a chronic disease, patients need proper treatment and conduct it continuously. Healer shopping was often taken by diabetes mellitus patients. It was required cooperation between patients and health professionals to monitor the behavior in order to achieve the effectiveness of medical treatment. Keyword: