Mangzhu Zhao

A NOVEL CHROMIUM TRIOXIDE CATALYZED OXIDATION OF PRIMARY ALCOHOLS TO THE CARBOXYLIC ACIDS

Abstract A novel CrO 3 catalyzed oxidation of primary alcohols to the carboxylic acids is reported. The oxidation proceeds smoothly with only 1–2 mol % of CrO 3 and 2.5 equivalents of H 5 IO 6 in wet MeCN to give the carboxylic acids in excellent yield. No significant racemization is observed for alcohols with adjacent chiral centers. Secondary alcohols are cleanly oxidized to ketones.

A convenient and economical method for the preparation of DIP-Chloridetm and its application in the asymmetric reduction of aralkyl ketones

A convenient and economical in situ preparation of DIP-Chloridetm from NaBH4, BCl3 and α-pinene is described. Its application in the asymmetric reduction of representative aralkyl ketones is presented.

Rhodium-carbenoid-mediated intermolecular O–H insertion reactions: a dramatic additive effect. Application in the synthesis of an ascomycin derivative

Abstract A catalyst system of Rh 2 (oct) 4 /DIPEA or TMU allows for the rapid construction of α-alkoxyketones from the corresponding α-diazo ketone and alcohol. This methodology was applied to the synthesis of immunoregulant 1 .