Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Mansur A. Sandhu is active.

Publication


Featured researches published by Mansur A. Sandhu.


European Journal of Histochemistry | 2014

Ontogenic development of corticotrophs in fetal buffalo (Bubalus bubalis) pituitary gland

Mansur A. Sandhu; A.A. Saeed; M.S. Khilji; R.H. Pasha; N. Mukhtar; M.S. Anjum

To evaluate the subpopulation of corticotrophs in developing buffalo (Bubalus bubalis) fetus, pituitary glands were recovered (n=6 per group) from late first, second and third gestational female buffalo dams. The corticotrophs were identified by using specific antibodies against proopiomelanocortin (POMC) and adrenocorticotrophic hormone (ACTH) through immunohistochemistry. There was a significant (P≤0.05) increase of immunoreactive (ir) ir-ACTH cells during late 2nd trimester while, ir-POMC cells were more (P≤0.05) at late 3rd trimester of gestation as compared to other age groups. The quantity of co-localized cells for POMC and ACTH was significantly (P≤0.05) greater at the end of 1st gestation rather than 2nd and 3rd gestational fetal adenohypophyseal cells. This study is the first to demonstrate co-localization of POMC+ACTH and the affect of gestational age on the expression of these cells in buffalo fetus adenohypophysis.


Biomedicine & Pharmacotherapy | 2018

Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats

Mousa O. Germoush; Sarah I. Othman; Maha A. Al-Qaraawi; Hanan M. Al-Harbi; Omnia E. Hussein; Gadh Al-Basher; Mohammed F. Alotaibi; Hassan A. Elgebaly; Mansur A. Sandhu; Ahmed A. Allam; Ayman M. Mahmoud

Hepatic encephalopathy (HE) is a serious neuropsychiatric complication that occurs as a result of liver failure. Umbelliferone (UMB; 7-hydroxycoumarin) is a natural product with proven hepatoprotective activity; however, nothing has yet been reported on its protective effect against hyperammonemia, the main culprit behind the symptoms of HE. Here, we evaluated the effect of UMB against ammonium chloride (NH4Cl)-induced hyperammonemia, oxidative stress, inflammation and hematological alterations in rats. We demonstrated the modulatory role of UMB on the glutamate-nitric oxide (NO)-cGMP pathways in the cerebrum of rats. Rats received intraperitoneal injections of NH4Cl (3 times/week) for 8 weeks and concomitantly received 50 mg/kg UMB. NH4Cl-induced rats showed significantly elevated blood ammonia and liver function markers. Lipid peroxidation and NO were increased in the liver and cerebrum of rats while the antioxidant defenses were declined. UMB significantly reduced blood ammonia, liver function markers, lipid peroxidation and NO, and enhanced the antioxidant defenses in NH4Cl-induced rats. UMB significantly prevented anemia, leukocytosis, thrombocytopenia and prolongation of PT and aPTT. Hyperammonemic rats showed elevated levels of cerebral TNF-α, IL-1β and glutamine as well as increased activity and expression of Na+/K+-ATPase, effects that were significantly reversed by UMB. In addition, UMB down-regulated nitric oxide synthase and soluble guanylate cyclase in the cerebrum of hyperammonemic rats. In conclusion, this study provides evidence that UMB protects against hyperammonemia via attenuation of oxidative stress and inflammation. UMB prevents hyperammonemia associated hematological alterations and therefore represents a promising protective agent against the deleterious effects of excess ammonia.


Journal of Trace Elements in Medicine and Biology | 2017

Effects of dietary chromium supplementation on muscle and bone mineral interaction in broiler chicken

Abdullah A. Saeed; Mansur A. Sandhu; Muhammad S. Khilji; M. S. Yousaf; H. Rehman; Zafar I. Tanvir; Tanveer Ahmad

The study was conducted to ascertain the effects of dietary chromium chloride (CrCl3·6H2O) supplementation on mineral interaction in blood serum, leg muscles and bones of broilers at 35th day of age. For this purpose, ninety male broiler chicks were divided into three groups. One served as control (group I) while, the other two groups were supplemented with CrCl3 (group II-12.5mg/Kg feed; group III-25mg/Kg feed) from 12 to 28days of age. In serum, Cr concentration remained non-significant however, Zn, and K concentrations decreased (P<0.05) with both levels of Cr-supplementation. Furthermore, in muscles Cr, Cu, Ca and Na levels remained non-significant but concentrations of Zn and K decreased (P<0.05) with feed Cr enrichment. Chromium had a substantial effect on femur and fibula Zn retention with 25mg/Kg feed supplementation while, Cr deposition decreased (P<0.05) in fibula. Femur Ca (P<0.002), Na (P<0.001) and K (P<0.05) retention was inversely proportional to both Cr concentrations in feed. In tibia, Cu and Na concentration decreased (P<0.002) with high dietary Cr supplementation. Fibular Ca and Na concentrations remained significantly (P<0.001) lower in Cr supplemented groups. Bone robusticity index was non-significant but ash to weight ratio of femur, tibia and fibula decreased (P<0.05) in group III. Chromium supplementation has a major effect on serum or muscle Zn and K deposition while bone mineral interaction shows a major thrust on Zn, Ca and Na levels.


Food Chemistry | 2018

Optimization of mixed surfactants-based β-carotene nanoemulsions using response surface methodology: An ultrasonic homogenization approach

Tahir Mehmood; Anwaar Ahmed; Asif Ahmad; Muhammad Sheeraz Ahmad; Mansur A. Sandhu

In the present study, food grade mixed surfactant-based β-carotene nanoemulsions were prepared without using any co-surfactant. Response surface methodology (RSM) along with central composite design (CCD) was used to investigate the effect of independent variables (surfactant concentration, ultrasonic homogenization time and oil content) on response variables. RSM analysis results revealed that experimental results were best fitted into a quadratic polynomial model with regression coefficient values of more than 0.900 for all responses. Optimized preparation conditions for β-carotene nanoemulsions were 5.82% surfactant concentration, 4 min ultrasonic homogenization time and 6.50% oil content. The experimental values at optimized preparation conditions were 119.33 nm droplet size, 2.67p-Anisidine value and 85.63% β-carotene retention. This study will be helpful for the fortification of aqueous products with β-carotene.


Tropical Animal Health and Production | 2014

Upgrade of egg quality through different heat-combating systems during high environmental temperature

Muhammad Safdar Anjum; Mansur A. Sandhu; Nasir Mukhtar; Zia-ur Rahman

The aim of the study was to find out the effect of various heat-combating systems (HCS) on the egg quality characteristics of commercial laying hens during high environmental temperature of the year. Three hundred pullets were wing banded and randomly divided into 15 experimental units comprising of 20 pullets each. These units were randomly allotted to five treatment groups, replicated thrice according to four heat-combating systems (desert cooling, water sprinkling, time limit feeding, ascorbic acid supplementation), and the control was maintained under the same housing system. The mean values of egg weight, eggshell thickness, Haugh unit, thick albumen height, yolk height, and yolk diameter were calculated. The layers kept under the influence of desert cooling produced eggs with more weight and thicker shells than those under other systems. Results of the present study did not show any difference in the shell thickness between water sprinkling and ascorbic acid supplementation as compared to the control group. Haugh unit and yolk index values obtained from the layers kept under various HCS did not significantly differ from those of the control group. All HCS significantly reduced the occurrence of blood spots in the eggs as compared to the control. All the treatments in general markedly reduced the incidence of meat spots in the eggs especially with the supplementation of ascorbic acid being the most effective. Among all of the treatments, the desert cooling system proved to be the best for producing better-quality eggs during hot periods of the year with less humidity.


Livestock Science | 2012

Effect of heat stress on cellular and humoral immunity and its cure with α-tocopherol in meat type birds

Mansur A. Sandhu; Fahd Q. Mirza; Farhan Afzal; Nasir Mukhtar


Journal of Toxicological Sciences | 2013

Genotoxicity evaluation of chlorpyrifos: a gender related approach in regular toxicity testing.

Mansur A. Sandhu; Abdullah A. Saeed; Muhammad S. Khilji; Anwaar Ahmed; Malik Shah Zaman Latif; Nauman Khalid


Inflammopharmacology | 2018

Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice

Mirza Muhammad Fahd Qadir; Attya Bhatti; Muhammad Ashraf; Mansur A. Sandhu; Sidrah Anjum; Peter John


International Journal of Agriculture and Biology | 2013

Managing immunocompetence of broiler chicken through vitamin E supplementation at low ambient temperature.

Mansur A. Sandhu; Mohsin Raza; Farhan Afzal; Fawwad Ahmad; M. S. Anjum


Turkish Journal of Veterinary & Animal Sciences | 2016

Circulating metabolic and reproductive hormone changes in laying hens kept under various heat-combating systems

Muhammad Safdar Anjum; Mansur A. Sandhu; Zia Ur-Rahman; Anum Safdar

Collaboration


Dive into the Mansur A. Sandhu's collaboration.

Top Co-Authors

Avatar

Abdullah A. Saeed

University of Veterinary and Animal Sciences

View shared research outputs
Top Co-Authors

Avatar

Muhammad S. Khilji

University of Veterinary and Animal Sciences

View shared research outputs
Top Co-Authors

Avatar

Anwaar Ahmed

Pir Mehr Ali Shah Arid Agriculture University

View shared research outputs
Top Co-Authors

Avatar

H. Rehman

University of Veterinary and Animal Sciences

View shared research outputs
Top Co-Authors

Avatar

M. S. Yousaf

University of Veterinary and Animal Sciences

View shared research outputs
Top Co-Authors

Avatar

Nasir Mukhtar

University of Agriculture

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge