Manu N. Mathur

Successful overlapping anal sphincter repair: Relationship to patient age, neuropathy, and colostomy formation

BACKGROUND: Fecal incontinence from single anal sphincter defects are surgically remedial and commonly the result of obstetric injuries. Overlapping anal sphincter repair has previously been associated in small series with good results in 69 to 97 percent of patients. OBJECTIVES: The aims of this study were to assess the results of overlapping anal sphincter repair in one institution and to assess the effects of age, presence of a neuropathy, and addition of a temporary colostomy on the success of surgery. METHODS: A study of 57 overlapping anal sphincter repairs in 56 (54 females) patients at the Royal Prince Alfred Hospital during a six-year period was performed. All patients were investigated preoperatively with endoanal ultrasound and concentric needle electromyography. Patients have been assessed prospectively since 1994 with a questionnaire, including a four-point Likert scale of continence level, the St. Marks incontinence scoring system (range, 0–13), the Pescatori incontinence scoring system (range, 0–6), and patient assessment of success or failure of the overlapping anal sphincter repair. A colostomy was selectively formed in conjunction with an overlapping anal sphincter repair in 21 patients (8 preoperatively, 13 simultaneously), and 18 patients had a concomitant neuropathy (3 unilateral, 15 bilateral). RESULTS: After a median follow-up of 18 months, median continence scores overall had improved from St. Marks incontinence scoring 13 to 3 (P<0.0001) and Pescatori incontinence scoring 6 to 2 (P<0.0001). Forty-nine of 57 (86 percent) repairs have been successful, and 8 are considered to be failures. Twenty-one of 27 (78 percent) repairs in patients younger than 40 years of age were successful, as were 28 of 30 (93 percent) repairs in patients older than 40 years of age (P=0.10). Four of 18 (22 percent) repairs associated with a neuropathy failed compared with 4 of 39 (10 percent) without a neuropathy (P=0.21). Improved or normal continence was achieved in 17 of 21 (81 percent) patients with a stoma and overlapping anal sphincter repair and in 32 of 36 (89 percent) patients with an overlapping anal sphincter repair alone (P=0.32). The presence of a stoma did not improve the rate of wound healing by primary intention (62 percent for stomavs. 64 percent for overlapping anal sphincter repair alone;P=0.55). CONCLUSIONS: Single anal sphincter defects can be successfully treated with an overlapping anal sphincter repair. There is no improvement in primary healing with selective stoma formation. Age of the patient and presence of a neuropathy should not detract from proceeding with overlapping anal sphincter repair when singular anal sphincter defects are detected on endoanal ultrasound in muscle that is still active.

Liberal use of axillary artery cannulation for aortic and complex cardiac surgery

OBJECTIVES Axillary artery cannulation for cardiopulmonary bypass has been described previously as a safe and reliable technique, with a low risk of atheroemboli, avoidance of malperfusion in aortic dissection and facilitation of selective antegrade cerebral perfusion during hypothermic circulatory arrest. The aim of this study was to document the broad applicability of axillary cannulation and its associated morbidity and identify where it was not possible to use planned axillary cannulation. METHODS A retrospective review of a single surgeons 10-year experience of axillary cannulation using the side-graft technique in 184 consecutive patients (age 22-92 years) in aortic and complex cardiac surgery from July 2002 to June 2012. RESULTS There were no intraoperative deaths and no major complications related to axillary artery use. There were six postoperative deaths unrelated to axillary artery cannulation. Six patients (3.3%) had minor complications as a direct result of axillary cannulation including seroma, haematoma, chronic pain and pectoralis major muscle atrophy. There were 10 cases where planned axillary cannulation was abandoned, due to inadequate size of the axillary artery in 8 patients and axillary artery dissection and morbid obesity in 1 patient each. CONCLUSIONS Axillary artery cannulation is an ideal arterial inflow site in cases where the ascending aorta is unsuitable as it is safe, reliable and reduces the risks of atheroembolization and malperfusion. Major complications are rare with this meticulous technique and it is our standard practice in complex cardiac and aortic surgery.

Axillary Artery Cannulation for Aortic and Complex Cardiac Surgery

BACKGROUND Cannulation of the axillary artery for cardiopulmonary bypass (CPB) avoids manipulation of an atherosclerotic, aneurysmal, or dissected ascending aorta. Advantages include: low risk of atheroemboli, low risk of malperfusion in dissections, and facilitates selective antegrade cerebral perfusion (SACP) during hypothermic circulatory arrest (HCA). METHODS A single surgeons seven year experience of axillary cannulation using the side-graft technique in 116 consecutive patients (age 22-87 years) in aortic and cardiac surgery where the ascending aorta was unapproachable. The indication for axillary cannulation was: (i) acute Type A dissection in 22, (ii) elective aortic surgery in 70, (iii) CPB prior to redo sternotomy in five, and (iv) a porcelain aorta in 19. HCA was used in 98 cases and additionally SACP was used in 18 cases. RESULTS There were three postoperative deaths, one from multi-system failure, one stroke, and one post discharge from an unknown cause. All 113 other patients were well and discharged home. There were no major complications related to axillary artery use. CONCLUSION Axillary artery cannulation is a safe and reliable technique for arterial inflow minimising the risks of atheroembolisation and malperfusion reflected by low morbidity and mortality, and should be the standard in aortic and complex cardiac surgery.

Constrictive Pericarditis Diagnosed by Cardiac Magnetic Resonance

![Figure][1] [![Graphic][3] ][3][![Graphic][4] ][4][![Graphic][5] ][5][![Graphic][6] ][6] The diagnosis of constrictive pericarditis is problematic, and management consequences are profound. A 68-year-old man was admitted with severe right-sided congestive heart failure

Malignant Cardiac Tamponade from Non-Small Cell Lung Cancer: Case Series from the Era of Molecular Targeted Therapy

Cardiac tamponade complicating malignant pericardial effusion from non-small cell lung cancer (NSCLC) is generally associated with extremely poor prognosis. With improved systemic chemotherapy and molecular targeted therapy for NSCLC in recent years, the prognosis of such patients and the value of invasive cardiothoracic surgery in this setting have not been adequately examined. We report outcomes from a contemporary case series of eight patients who presented with malignant cardiac tamponade due to NSCLC to an Australian academic medical institution over an 18 months period. Two cases of cardiac tamponade were de novo presentations of NSCLC and six cases were presentations following previous therapy for NSCLC. The median survival was 4.5 months with a range between 9 days to alive beyond 17 months. The two longest survivors are still receiving active therapy at 17 and 15 months after invasive surgical pericardial window respectively. One survivor had a histological subtype of large cell neuroendocrine carcinoma and the other received targeted therapy for epidermal growth factor receptor mutation. These results support the consideration of active surgical palliation to treating this oncological emergency complicating NSCLC, including the use of urgent drainage, surgical creation of pericardial window followed by appropriate systemic therapy in suitably fit patients.

Right atrial Merkel cell tumour metastasis characterization using a multimodality approach

An 80-year-old man with a history of left axillary Merkel cell carcinoma treated with chemoradiotherapy had an incidental finding of right atrial filling defect at mesenteric computed tomographic (CT) angiogram ( Panel A ). The multilobulated mass was confirmed …

Localized malignant pleural mesothelioma with renal metastasis

Localized malignant pleural mesothelioma (LMM) is a rare subset of malignant pleural mesothelioma. Its epidemiology, biology, natural history and optimal treatment are poorly understood. We report a case of LMM treated aggressively with complete surgical resection and adjuvant radiotherapy, but subsequently complicated by local chest wall recurrence and solitary metastasis to the kidney. This case is examined in the context of a small number of cases of LMM in the literature to emphasize the existence of this rare disease entity, their unusual biological behaviour and the need for further tumour molecular and genomic research.

Recannulation of the axillary artery in aortic and complex cardiac surgery

Axillary artery cannulation has been used as an alternative site for cardiopulmonary bypass during surgery for aortic dissections and aneurysmal disease of the ascending aorta and arch. This study reports our experience with reusing the axillary artery for cardiopulmonary bypass during complex aortic and cardiac surgical procedures.

Long Term Outcomes Following Freestyle Stentless Aortic Bioprosthesis Implantation: An Australian Experience.

BACKGROUND The Freestyle stentless bioprosthesis (FSB) has been demonstrated to be a durable prosthesis in the aortic position. We present data following Freestyle implantation for up to 10 years post-operatively and compare this with previously published results. METHODS A retrospective cohort analysis of 237 patients following FSB implantation occurred at five Australian hospitals. Follow-up data included clinical and echocardiographic outcomes. RESULTS The cohort was 81.4% male with age 63.2±13.0 years and was followed for a mean of 2.4±2.3 years (range 0-10.9 years, total 569 patient-years). The FSB was implanted as a full aortic root replacement in 87.8% patients. The 30-day all cause mortality was 4.2% (2.0% for elective surgery). Cumulative survival at one, five and 10 years was 91.7±1.9%, 82.8±3.8% and 56.5±10.5%, respectively. Freedom from re-intervention at one, five and 10 years was 99.5±0.5%, 91.6±3.7% and 72.3±10.5%, respectively. At latest echocardiographic review (mean 2.3±2.1 years post-operatively), 92.6% had trivial or no aortic regurgitation. Predictors of post-operative mortality included active endocarditis, acute aortic dissection and peripheral vascular disease. CONCLUSIONS We report acceptable short and long term outcomes following FSB implantation in a cohort of comparatively younger patients with thoracic aortic disease. The durability of this bioprosthesis in the younger population remains to be confirmed.

An unusual cause of myocardial ischaemia

Insertion of an Implantable Cardiac Defibrillator (ICD) has been demonstrated to improve cardiac and overall survival in selected patients at risk of sudden cardiac death [1]. The wide range of patients that benefit from ICD insertion have resulted in implantation of such devices becoming commonplace. Peri-procedural complications are uncommon, with an overall incidence of approximately 3% and the most common complications comprise localised haematoma over the site of the generator, lead displacement and haemothorax [2]. We describe a rare but potentially fatal complication related to ICD insertion in a patient who had previously undergone coronary artery bypass grafting (CABG). A 52 year old man with a history of myocardial infarction and previous CABG presented with ventricular tachycardia and haemodynamic embarrassment requiring emergent electrical cardioversion. Subsequent cardiac biomarkers and electrolytes were within normal limits. Transthoracic echocardiography (TTE) demonstrated inferobasal hypokinesis with mild-moderately impaired left ventricular systolic function. Coronary angiography was performed and demonstrated patent grafts (left internal mammary artery (LIMA) graft to the left anterior descending (LAD) with a saphenous veins graft to the posterior descending branch of the right coronary artery and obtuse marginal). The patient underwent insertion of an implantable cardiac defibrillator (ICD) with standard atrial and ventricular leads inserted via the left subclavian vein. One hour following the end of the procedure the patient complained of retrosternal chest pain. Electrocardiograph (ECG) demonstrated