Manuel Méndez Bailón

Determinación del fragmento N-terminal del propéptido natriurético cerebral (NTproBNP) en pacientes de edad avanzada con disnea aguda: valor diagnóstico y pronóstico

BACKGROUND AND OBJECTIVE The aim of our study was to establish weather N-terminal fragment of brain-type natriuretic peptide (NT-proBNP) is useful in the differential diagnosis of dyspnea in elderly patients, and whether its determination has a prognostic value in heart failure (HF). PATIENTS AND METHOD 79 patients admitted with acute dyspnea at the emergency department were included in our study. The mean age (standard deviation) was 77.56 (8.71) years. 67% had a diagnosis of HF based on clinical and echocardiagraphic criteria. A follow-up of 18 months was performed after discharge. RESULTS Higher levels of NT-proBNP were found in patients with HF (6,833.54 pg/ml) than in patients with other causes of dyspnea (1,801.99 pg/ml) (p 730 pg/ml was related to higher rates of readmission due to HF over the next 18 months. CONCLUSIONS NT-proBNP is a useful biomarker in the differential diagnosis of dyspnea in the elderly population. Its determination has a prognostic roll, stratifying the risk of readmission in HF patients.BACKGROUND AND OBJECTIVE: The aim of our study was to establish weather N-terminal fragment of brain-type natriuretic peptide (NT-proBNP) is useful in the differential diagnosis of dyspnea in elderly patients, and whether its determination has a prognostic value in heart failure (HF). PATIENTS AND METHOD: 79 patients admitted with acute dyspnea at the emergency department were included in our study. The mean age (standard deviation) was 77.56 (8.71) years. 67% had a diagnosis of HF based on clinical and echocardiagraphic criteria. A follow-up of 18 months was performed after discharge. RESULTS: Higher levels of NT-proBNP were found in patients with HF (6,833.54 pg/ml) than in patients with other causes of dyspnea (1,801.99 pg/ml) (p 730 pg/ml was related to higher rates of readmission due to HF over the next 18 months. CONCLUSIONS: NT-proBNP is a useful biomarker in the differential diagnosis of dyspnea in the elderly population. Its determination has a prognostic roll, stratifying the risk of readmission in HF patients.

Fragmento N-terminal del propéptido natriurético cerebral en el diagnóstico de la insuficiencia cardíaca aguda: ¿dónde nos encontramos ahora?

. Por este motivo, son necesarios nuevos marcadores de determinacion rapida y accesible que permitan objetivar la disfuncion ventricular de los pacientes con sospecha de IC aguda. En este aspecto, tanto el peptido natriuretico cerebral o tipo B (BNP) como su forma inactiva, el fragmento aminoterminal (NT-proBNP), han demostrado ser marcadores diagnosticos de utilidad a la hora de evaluar al paciente con disnea y sospecha de IC. En el estudio PRIDE (Pro-BNP Investigation of Dyspnea in