Manuel O. Lagravère

Three-dimensional accuracy of measurements made with software on cone-beam computed tomography images.

INTRODUCTION The purpose of this article was to evaluate the accuracy of measurements made on 9- and 12-in cone-beam computed tomography (CBCT) images compared with measurements made on a coordinate measuring machine (CMM), which is the gold standard. METHODS Ten markers were placed on a synthetic mandible, and landmark coordinates and linear and angular measurements were determined with the CMM. Three-dimensional CBCT images, measuring 9 and 12 in, were taken of the mandible with a CBCT machine (NewTom 3G, Aperio Services, Verona, Italy), and landmark coordinates and linear and angular measurements were obtained with AMIRA (Mercury Computer Systems, Berlin, Germany) software. RESULTS The coordinate intrareliability correlation coefficient was almost perfect between the 3-dimensional CBCT images and the CMM measurements. With the Student t test, we found no significant statistical difference between linear and angular measurements from the CMM and the NewTom 3G images, which differed less than 1 mm and 1 degrees , respectively. CONCLUSIONS The NewTom 3G produces a 1-to-1 image-to-reality ratio.

Long-term Skeletal Changes with Rapid Maxillary Expansion: A Systematic Review

The objective was to evaluate long-term transverse, anteroposterior and vertical skeletal changes after rapid maxillary expansion (RME). The data were clinical trials that assessed skeletal changes through cephalometric analysis. No surgical or other simultaneous treatment during the evaluation period was accepted. Electronic databases (PubMed, Medline, Medline In-Process & Other Non-Indexed Citations, Cochrane Database of Systematic Reviews, ASP Journal Club, DARE, CCTR, Embase, Web of Sciences and Lilacs) were searched with the help of a senior Health Sciences librarian. Abstracts that appeared to fulfill the initial selection criteria were selected by consensus. The original articles were then retrieved. A methodological checklist was used to evaluate the quality of the selected articles. Their references were also hand-searched for possible missing articles. Articles without an adequate control group to factor out growth changes were excluded. Only three articles (one measuring transverse and two anteroposterior and vertical changes) measured RME stability after active expansion, all of them had some methodological flaws, which limit the attainable conclusions. An individual analysis of these articles was made. Long-term transverse skeletal maxillary increase is approximately 25% of the total dental expansion for prepubertal adolescents. Better long-term outcomes are expected in transverse changes because of RME in less skeletally mature patients. RME appears not to produce clinically significant anteroposterior or vertical changes in the position of the maxilla and mandible. The conclusions from this systematic review should be considered with caution because only a secondary level of evidence was found. Long-term randomized clinical trials are needed.

Long-term dental arch changes after rapid maxillary expansion treatment: a systematic review

This systematic review evaluates long-term dental arch changes after rapid maxillary expansion treatment on orthodontic patients with constricted arches. Clinical trials that assessed dental arch changes through measurements on dental casts or cephalometric radiographs were selected. No patients with surgical or other simultaneous treatment during the active expansion period were accepted. Electronic databases were searched with the help of a senior Health Sciences librarian. Original articles were retrieved from the selected abstracts, and their references were also scanned for possible missing articles. Forty-one articles met the initial inclusion criteria, but 35 were later rejected because they lacked a control group or only evaluated dental changes or used a semirapid technique. Some of them also lacked a reported measurement error. From the remaining articles, two did not report a long-term evaluation. From the final four articles, two measured changes through dental casts and two assessed changes through radiographs (one through lateral cephalometric radiographs and one through posteroanterior radiographs). Similar maxillary molar and cuspid expansion could be found in adolescents and young adults. Significantly less indirect mandibular molar and cuspid expansion was attained in young adults compared with adolescents. A significant overall gain in the maxillary and mandibular arch perimeter was found in adolescents. More transverse dental arch changes were found after puberty as compared with before, but the difference may not be clinically significant. No anteroposterior dental changes were found on lateral cephalometric radiographs.

Transverse, vertical, and anteroposterior changes from bone-anchored maxillary expansion vs traditional rapid maxillary expansion: A randomized clinical trial

INTRODUCTION The purpose of this study was to compare the transverse, vertical, and anteroposterior skeletal and dental changes in adolescents receiving expansion treatment with tooth-borne and bone-anchored expanders. Immediate and long-term changes were measured on cone-beam computed tomography (CBCT) images. METHODS Sixty-two patients needing maxillary expansion were randomly allocated to 1 of 3 groups: traditional hyrax tooth-borne expander, bone-anchored expander, and control. CBCT images were taken at baseline, immediately after expansion, after removal of the appliance (6 months), and just before fixed bonding (12 months). Repeated measures multivariate analysis of variance (MANOVA) was applied to the distances and angles measured to determine the statistical significance in the immediate and long time periods. Bonferroni post-hoc tests were used to identify significant differences between the treatment groups. RESULTS Immediately after expansion, the subjects in the tooth-borne expander group had significantly more expansion at the crown level of the maxillary first premolars (P = 0.003). Dental crown expansion was greater than apical expansion and skeletal expansion with both appliances. The control group showed little change (growth) over the 6-month interval. At 12 months, no group had a statistically significant difference in angle changes, suggesting symmetric expansion. Both treatment groups had significant long-term expansion at the level of the maxillary first molar crown and root apex, first premolar crown and root, alveolus in the first molar and premolar regions, and central incisor root. Tooth-borne expansion resulted in significantly more long-term expansion at the maxillary premolar crown and root than did bone-borne expansion. CONCLUSIONS Both expanders showed similar results. The greatest changes were seen in the transverse dimension; changes in the vertical and anteroposterior dimensions were negligible. Dental expansion was also greater than skeletal expansion.

Intraexaminer and interexaminer reliabilities of landmark identification on digitized lateral cephalograms and formatted 3-dimensional cone-beam computerized tomography images

INTRODUCTION The purposes of this study were to determine and compare the intraexaminer and interexaminer reliabilities of commonly used cephalometric landmarks identified on digitized lateral cephalograms and formatted cone-beam computerized tomography (CBCT) images. METHODS CBCT images from 10 randomly selected adolescent patients were obtained from the orthodontic records of a private practice. Measurement errors, and intraexaminer, and interexaminer reliability correlation coefficients (ICC) were obtained for all landmark coordinates. RESULTS Intraexaminer and interexaminer reliabilities for all coordinates for most landmarks on the digital lateral cephalograms and CBCT images were greater than 0.9 (ICC value). The means of landmark locations differed by approximately 1 mm in most coordinates from the lateral cephalograms and were predominantly higher than 1 mm for all coordinates from the CBCT images. CONCLUSIONS Intraexaminer and interexaminer reliabilities were high for most landmarks. Coordinates with greater measurement errors in the lateral cephalograms (condylion, gonion, porion, mandibular incisor apex, and posterior nasal spine) were in structures without clearly defined borders. In the CBCT images, gonion, condylion, and porion were located on surfaces that were flat or curved, making it difficult to recognize a specific reference point. Other less reliable landmarks (anterior nasal spine, posterior nasal spine, mandibular incisor apex) were located in structures with lower densities and could not be visualized with 3-dimensional reconstruction; thus, they had high measurement errors.

Effect of object location on the density measurement and Hounsfield conversion in a NewTom 3G cone beam computed tomography unit

OBJECTIVES The purpose of this study was to determine the effect of an objects location in a cone beam CT imaging chamber (CBCT-NewTom 3G) on its apparent density and to develop a linear conversion coefficient for Hounsfield units (HU) to material density (g cm(-3)) for the NewTom 3G Scanner. METHODS Three cylindrical models of materials with different densities were constructed and scanned at five different locations in a NewTom 3G Volume Scanner. The average HU value for each model at each location was obtained using two different types of software. Next, five cylinders of different known densities were scanned at the exact centre of a NewTom 3G Scanner. The collected data were analysed using the same two types of software to determine a standard linear relationship between density and HU for each type of software. RESULTS There is no statistical significance of location of an object within the CBCT scanner on determination of its density. A linear relationship between the density of an object and the HU of a scan was rho = 0.001(HU)+1.19 with an R2 value of 0.893 (where density, rho, is measured in g cm(-3)). This equation is to be used on a range between 1.42 g cm(-3) and 0.4456 g cm(-3). CONCLUSIONS A linear relationship can be used to determine the density of materials (in the density range of bone) from the HU values of a CBCT scan. This relationship is not affected by the objects location within the scanner itself.

Implant vs screw loading protocols in orthodontics.

OBJECTIVE This systematic review presents the loading protocols applied when using implants and/or screws in orthodontic treatments. MATERIALS AND METHODS Clinical trials which assessed the use of implants and/or screws for orthodontic anchorage and studies involving treatment on syndromic patients, surgery, other simultaneous treatments, or appliances (ie mini-plates) were considered. Electronic databases (Medline, Medline In-Process & Other Non-Indexed Citations, Lilacs, Pubmed, Embase, Web of Science, and All Evidence Based Medicine Reviews) were searched with the help of a senior Health Sciences librarian. Abstracts which appeared to fulfill the selection criteria were selected by consensus. The original articles were then retrieved and evaluated with a methodological checklist. References were also hand searched for possible missing articles. RESULTS Eleven articles fulfilled the selection criteria established. Five studies involved the use of implants while six involved the use of screws for orthodontic purposes. An individual methodological analysis for each article was made. CONCLUSIONS Loading protocols for implants involve a minimum waiting period of 2 months before applying orthodontic forces while loading protocols for screws involve immediate loading or a waiting period of 2 weeks to apply forces. Success rates for implants were on average higher than for screws.

Reliability of traditional cephalometric landmarks as seen in three-dimensional analysis in maxillary expansion treatments.

OBJECTIVE To evaluate intra-examiner and inter-examiner reliability of 3D CBCT-generated landmarks previously used in traditional 2D cephalometry. MATERIALS AND METHODS Twenty-four CBCTs NewTom 3G (Aperio Services, Verona, Italy) were randomly selected from patients participating in a clinical trial involving maxillary expansion treatments. The principal investigator located the landmarks five times, and four other investigators located the same landmarks once. Intra-examiner and inter-examiner reliability values were determined using intraclass correlation coefficients (ICCs). To assist in interpretation of the clinical significance of landmark identification differences, average mean differences for x, y, and z landmark coordinates were determined from the repeated assessments. Landmarks then were separated into groups with respect to the region they represented and then were compared via repeated measures ANOVA and multiple comparisons via Bonferroni corrected alpha. RESULTS Intra-examiner and inter-examiner reliability for x, y, and z coordinates for all landmarks were acceptable, all being greater than 0.80. Most of the mean measurement differences obtained from trials within the principal investigator in all three axes were less than 1.5 mm. Inter-examiner mean measurement differences generally were larger than the intra-examiner differences. CONCLUSIONS Based on this, the best landmarks for use in verifying expansion treatment results are Ekm, buccal surface, and apexes of upper molars, upper premolars and upper canines, and buccal surfaces of lower molars and lower canines. Foramen Spinosum, ELSA, Auditory External Meatus, and Dorsum Foramen Magnum demonstrated adequate reliability for determining a standardized reference system.

Reproducibility, reliability and validity of measurements obtained from Cecile3 digital models.

The aim of this study was to determine the reproducibility, reliability and validity of measurements in digital models compared to plaster models. Fifteen pairs of plaster models were obtained from orthodontic patients with permanent dentition before treatment. These were digitized to be evaluated with the program Cécile3 v2.554.2 beta. Two examiners measured three times the mesiodistal width of all the teeth present, intercanine, interpremolar and intermolar distances, overjet and overbite. The plaster models were measured using a digital vernier. The t-Student test for paired samples and interclass correlation coefficient (ICC) were used for statistical analysis. The ICC of the digital models were 0.84 +/- 0.15 (intra-examiner) and 0.80 +/- 0.19 (inter-examiner). The average mean difference of the digital models was 0.23 +/- 0.14 and 0.24 +/- 0.11 for each examiner, respectively. When the two types of measurements were compared, the values obtained from the digital models were lower than those obtained from the plaster models (p < 0.05), although the differences were considered clinically insignificant (differences < 0.1 mm). The Cécile digital models are a clinically acceptable alternative for use in Orthodontics.

Sensitivity analysis for plane orientation in three-dimensional cephalometric analysis based on superimposition of serial cone beam computed tomography images

OBJECTIVES The purpose of this study was to evaluate the potential errors associated with superimposition of serial cone beam CT (CBCT) images utilizing reference planes based on cranial base landmarks using a sensitivity analysis. METHODS CBCT images from 62 patients participating in a maxillary expansion clinical trial were analysed. The left and right auditory external meatus (AEM), dorsum foramen magnum (DFM) and the midpoint between the left and right foramen spinosum (ELSA) were used to define a three-dimensional (3D) anatomical reference co-ordinate system. Intraclass correlation coefficients for all four landmarks were obtained. Transformation of the reference system was carried out using the four landmarks and mathematical comparison of values. RESULTS Excellent intrareliability values for each dimension were obtained for each landmark. Evaluation of the method to transform the co-ordinate system was first done by comparing interlandmark distances before and after transformations, giving errors in lengths in the order of 10-14% (software rounding error). A sensitivity evaluation was performed by adding 0.25 mm, 0.5 mm and 1 mm error in one axis of the ELSA. A positioning error of 0.25 mm in the ELSA can produce up to 1.0 mm error in other cranial base landmark co-ordinates. These errors could be magnified to distant landmarks where in some cases menton and infraorbital landmarks were displaced 4-6 mm. CONCLUSIONS Minor variations in location of the ELSA, both the AEM and the DFM landmarks produce large and potentially clinically significant uncertainty in co-ordinate system alignment.