Marc Diensthuber
Goethe University Frankfurt
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Publication
Featured researches published by Marc Diensthuber.
Oncology Reports | 2012
Christin Geissler; Markus Hambek; Anne Eckardt; Christoph Arnoldner; Marc Diensthuber; T. Stöver; Jens Wagenblast
One challenge of squamous cell carcinoma of the head and neck (SCCHN) chemotherapy is a small percentage of tumor cells that arrest in the G0 phase of the cell cycle and are thus not affected by chemotherapy. This could be one reason for tumor recurrence at a later date. The recruitment of these G0-arresting cells into the active cell cycle and thus, proliferation, may increase the efficacy of chemotherapeutic agents. The aim of this study was to investigate whether stimulation with recombinant epidermal growth factor (EGF) or serotonin leads to an increased tumor cell proliferation in xenografts. Detroit 562 cells were injected into NMRI-Foxn1nu mice. Treatment was performed with 15 μg murine or human EGF, or 200 μg serotonin. The control mice were treated with Lactated Ringer’s solution (5 mice/group). Tumor size was measured on days 4, 8 and 12 after tumor cell injection. The EGF stimulated mice showed a significantly higher tumor growth compared to the serotonin-stimulated mice and the untreated controls. In the present study, we show that it is possible to stimulate tumor cells in xenografts by EGF and thus, enhance cell proliferation, resulting in a higher tumor growth compared to the untreated control group. In our future investigations, we plan to include a higher number of mice, an adjustment of the EGF dosage and cell subanalysis, considering the heterogeneity of SCCHN tumors.
Anticancer Research | 2013
Aykut Tahtali; Christiane Hey; Christin Geissler; Natalie Filman; Marc Diensthuber; Martin Leinung; T. Stöver; Jens Wagenblast
Oncology Letters | 2012
Jens Wagenblast; Daniel Hirth; Laura Thron; Christoph Arnoldner; Marc Diensthuber; T. Stöver; Markus Hambek
Anticancer Research | 2013
Christin GEIßLER; Aykut Tahtali; Marc Diensthuber; Davina Gassner; T. Stöver; Jens Wagenblast
in Vivo | 2010
Jens Wagenblast; Oliver F. Adunka; Wolfgang Gstöttner; Christoph Arnoldner; Niklas Riedl; Marc Diensthuber; T. Stöver; Markus Hambek
Molecular and Clinical Oncology | 2013
Jens Wagenblast; Daniel Hirth; Anne Eckardt; Martin Leinung; Marc Diensthuber; T. Stöver; Markus Hambek
Oncology Letters | 2012
Martin Leinung; Clemens Cuny; Marc Diensthuber; T. Stöver; Jens Wagenblast
Oncology Letters | 2012
Martin Leinung; Daniel Hirth; Aykut Tahtali; Marc Diensthuber; T. Stöver; Jens Wagenblast
Hno | 2015
A. Jäger; R. Herbeck; Jens Wagenblast; T. Stöver; Marc Diensthuber
Hno | 2015
A. Jäger; R. Herbeck; Jens Wagenblast; T. Stöver; Marc Diensthuber