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Dive into the research topics where Marcel Mirel Popa is active.

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Featured researches published by Marcel Mirel Popa.


ACS Combinatorial Science | 2012

Efficient One-Pot, Three-Component Synthesis of a Library of Pyrrolo[1,2-c]pyrimidine Derivatives

Emilian Georgescu; Florentina Georgescu; Marcel Mirel Popa; Constantin Draghici; Laszlo Tarko; Florea Dumitrascu

Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium and HBr scavanger. This method proved to be very lucrative and avoids formation of ylide inactivation products. The synthesis represents an environmentally benign alternative to classical methods. The new library of compounds was briefly characterized regarding the improved Lipinski rule to asses the potential drug-likeness of the compounds. The majority of compounds are statisfing the Lipinski rule.


Molecules | 2013

Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

Florea Dumitrascu; Emilian Georgescu; Florentina Georgescu; Marcel Mirel Popa; Denisa Dumitrescu

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.


Beilstein Journal of Organic Chemistry | 2015

Indolizines and pyrrolo(1,2-c)pyrimidines decorated with a pyrimidine and a pyridine unit respectively

Marcel Mirel Popa; Emilian Georgescu; Mino R. Caira; Florentina Georgescu; Constantin Draghici; Raluca Stan; Calin Deleanu; Florea Dumitrascu

Summary The three possible structural isomers of 4-(pyridyl)pyrimidine were employed for the synthesis of new pyrrolo[1,2-c]pyrimidines and new indolizines, by 1,3-dipolar cycloaddition reaction of their corresponding N-ylides generated in situ from their corresponding cycloimmonium bromides. In the case of 4-(3-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine the quaternization reactions occur as expected at the pyridine nitrogen atom leading to pyridinium bromides and consequently to new indolizines via the corresponding pyridinium N-ylides. However, in the case of 4-(2-pyridyl)pyrimidine the steric hindrance directs the reaction to the pyrimidinium N-ylides and, subsequently, to the formation of the pyrrolo[1,2-c]pyrimidines. The new pyrrolo[1,2-c]pyrimidines and the new indolizines were structurally characterized through NMR spectroscopy. The X-ray structures of two of the starting materials, 4-(2-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine, are also reported.


Combinatorial Chemistry & High Throughput Screening | 2013

Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation

Emilian Georgescu; Florentina Georgescu; Constantin Draghici; Liliana Cristian; Marcel Mirel Popa; Florea Dumitrascu

A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.


E-polymers | 2008

Novel polymeric surfactants and their applications in miniemulsions

Lucretiu Cismaru; Thierry Hamaide; Marcel Mirel Popa

Abstract N-Vinyl-2-pyrrolidone (NVP) and maleic anhydride (MA) copolymers were synthesized via radical polymerization. The synthesized copolymers were grafted with methoxypolyethylene glycol (MPEG) chains of different average molecular weights (350, 550, 750 Da). The grafted copolymers were used as surfactants in the synthesis of poly(ε-caprolactone) (PCL) nanoparticles in water by solvent evaporation technique. In order to further test the synthesized surfactants, the miniemulsion polymerization of vinyl acetate was performed. Two methods of obtaining miniemulsion were employed: a sonicator and a static mixer. The synthesized surfactants performed well in both type of experiments while in the case of static mixer nanoparticles with a lower polydispersity were obtained. Droplets with a mean diameter of 250 nm were obtained when using the sonicator while the static mixer led to formation of droplets with a mean diameter of 600 nm.


Cellulose Chemistry and Technology | 2012

New approaches in hydrogel synthesis -- Click chemistry: A review

Ancuta Uliniuc; Marcel Mirel Popa; Thierry Hamaide; M. Dobromir


Synlett | 2010

New Pyrrolo[2,1-a]phthalazine Derivatives byOne-Pot Three-Component Synthesis

Florea Dumitrascu; Miron T. Caproiu; Florentina Georgescu; Bogdan Draghici; Marcel Mirel Popa; Emilian Georgescu


European Polymer Journal | 2007

Itaconic anhydride based amphiphilic copolymers : Synthesis, characterization and stabilization of carboxyl functionalized, PEGylated nanoparticles

Lucretiu Cismaru; Thierry Hamaide; Marcel Mirel Popa


Heteroatom Chemistry | 2011

Generation of pyrrolo[2,1-a]isoquinoline derivatives from N-ylides: Synthetic control and structural characterization

Florea Dumitrascu; Mino R. Caira; Emilian Georgescu; Florentina Georgescu; Constantin Draghici; Marcel Mirel Popa


ChemInform | 2010

POLYMERIC NANOPARTICLES WITH BIOMEDICAL APPLICATIONS

Lucretiu Cismaru; Marcel Mirel Popa

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