Marcela Frazier

Effect of Age on Response to Amblyopia Treatment in Children

OBJECTIVE To determine whether age at initiation of treatment for amblyopia influences the response among children 3 to less than 13 years of age with unilateral amblyopia who have 20/40 to 20/400 amblyopic eye visual acuity. METHODS A meta-analysis of individual subject data from 4 recently completed randomized amblyopia treatment trials was performed to evaluate the relationship between age and improvement in logMAR amblyopic eye visual acuity. Analyses were adjusted for baseline amblyopic eye visual acuity, spherical equivalent refractive error in the amblyopic eye, type of amblyopia, prior amblyopia treatment, study treatment, and protocol. Age was categorized (3 to <5 years, 5 to <7 years, and 7 to <13 years) because there was a nonlinear relationship between age and improvement in amblyopic eye visual acuity. RESULTS Children from 7 to less than 13 years of age were significantly less responsive to treatment than were younger age groups (children from 3 to <5 years of age or children from 5 to <7 years of age) for moderate and severe amblyopia (P < .04 for all 4 comparisons). There was no difference in treatment response between children 3 to less than 5 years of age and children 5 to less than 7 years of age for moderate amblyopia (P = .67), but there was a suggestion of greater responsiveness in children 3 to less than 5 years of age compared with children 5 to less than 7 years of age for severe amblyopia (P = .09). CONCLUSIONS Amblyopia is more responsive to treatment among children younger than 7 years of age. Although the average treatment response is smaller in children 7 to less than 13 years of age, some children show a marked response to treatment.

Validity of the convergence insufficiency symptom survey: a confirmatory study.

Purpose. The objectives of the present study were to evaluate whether investigator bias influenced the Convergence Insufficiency Symptom Survey (CISS) scores of children with normal binocular vision (NBV) in our original validation study, reevaluate the usefulness of the cutoff score of 16, and reexamine the validity of the CISS. Methods. Six clinical sites participating in the Convergence Insufficiency Treatment Trial (CITT) enrolled 46 children 9 to <18 years with NBV. Examiners masked to the child’s binocular vision status administered the CISS. The mean CISS score was compared with that from the children with NBV in the original, unmasked CISS study and also to that of the 221 symptomatic convergence insufficiency (CI) children enrolled in the CITT. Results. The mean (±standard deviation) CISS score for 46 subjects with NBV was 10.4 (±8.1). This was comparable with our prior unmasked NBV study (mean = 8.1 (±6.2); p = 0.11) but was significantly different from that of the CITT CI group (mean = 29.8 ± 9.0; p < 0.001). Eighty-three percent of these NBV subjects scored <16 on the CISS, which is not statistically different from the 87.5% found in the original unmasked study (p = 0.49). Conclusions. Examiner bias did not affect the CISS scores for subjects with NBV in our prior study. The CISS continues to be a valid instrument for quantifying symptoms in 9 to <18-year-old children. These results also confirm the validity of a cut-point of ≥16 in distinguishing children with symptomatic CI from those with NBV.

Treatment of ocular toxocariasis with albendezole: A case report

BACKGROUND Toxocara canis is a parasite that can infect the eye and create a significant inflammatory response that can be detrimental to the patients vision. Its clinical presentation can mimic other causes of uveitis, and its diagnosis and treatment can be challenging. Prompt and accurate diagnosis of ocular toxocariasis is essential to prevent permanent visual loss. CASE REPORT A 7-year-old Hispanic boy presented to the clinic with complaints of reduced visual acuity in the left eye. After a careful evaluation of his ocular health, he had ocular toxocariasis diagnosed and confirmed by enzyme-linked immunosorbent assay testing. Treatment with the anthelmintic, albendazole, and oral steroids was initiated. There was initial improvement of the vitritis with significant vitreous debris. However, 2 years later, reactivation occurred, and a vitrectomy was required. This case report reviews the management of a patient with active ocular toxocariasis, including clinical findings and treatment options. CONCLUSIONS The differential diagnosis of ocular toxocariasis and review of the available treatments are presented.

Seeking Eye Care for Children: Perceptions among Hispanic Immigrant Parents

The purpose of this study was to evaluate the perceptions related to seeking eye care for their children among Hispanic immigrant parents. Five focus group discussions with approximately eight Hispanic immigrant parents each were carried out using a designed topic guide to encourage dialogue. Discussion was tape-recorded and transcribed. Qualitative analysis was performed to identify and classify perceived barriers, motivators and possible future interventions. Parents agreed they would take the child to the eye specialist for visible problems, or if recommended by the pediatrician or required for school entry. The most frequently mentioned barriers included cost and the absence of signs, symptoms or a family history of eye problems. Parents identified a need for more information about common pediatric eye conditions, especially non-obvious problems like refractive error. Evaluation of perceptions and barriers is a necessary first step towards developing culturally relevant and effective interventions.

Knowledge, attitudes, and environment: what primary care providers say about pre-school vision screening.

Purpose. To evaluate knowledge, attitudes, and environment of primary care providers, and to develop a conceptual framework showing their impact on self-reported pre-school vision screening (PVS) behaviors. Methods. Eligible primary care providers were individuals who filed claims with Medicaid agencies in Alabama, South Carolina, or Illinois, for at least eight well child checks for children aged 3 or 4 years during 1 year. Responses were obtained on-line from providers who enrolled in the intervention arm of a randomized trial to improve PVS. We calculated a summary score per provider per facet: (1) for behavior and knowledge, each correct answer was assigned a value of +1; and (2) for attitudes and environment, responses indicating support for PVS were assigned a value of +1, and other responses were assigned −1. Results. Responses were available from 53 participants (43 of 49 enrolled pediatricians, 8 of 14 enrolled family physicians, one general physician, and one nurse practitioner). Recognizing that amblyopia often presents without outward signs was positively related to good PVS: [odds ratio (OR) = 3.9; p = 0.06]. Reporting that “preschool VS interrupts patient flow” posed a significant barrier (OR = 0.2; p = 0.05). Providers with high summed scores on attitudes (OR = 6.0; p = 0.03), or knowledge and attitudes (OR = 11.4; p < 0.001) were significantly more likely to report good PVS behavior. There was a significant trend between the number of “good” scores on knowledge, attitudes or environment, and “good” PVS behavior (p = 0.04). Conclusions. PVS is influenced by positive attitudes, especially when combined with knowledge about amblyopia. Interventions to improve PVS should target multiple facets, emphasizing (1) asymptomatic children are at risk for amblyopia, (2) specific evidence-based tests have high testability and sensitivity for amblyopia in pre-school children, and (3) new tests minimize interruptions to patient flow.

Engaging a Community in Developing an Entertainment–Education Spanish-Language Radio Novella Aimed at Reducing Chronic Disease Risk Factors, Alabama, 2010–2011

Background US Hispanics have disproportionate rates of diabetes and other chronic diseases. We used the entertainment–education approach to develop a Spanish-language radio novella aimed at reducing risk factors for diabetes, obesity, and tobacco use. The approach is based on social cognitive theory and proposes modeling as a source of vicarious learning of outcome and efficacy expectations. Community Context The Hispanic population in Alabama increased by 145% between 2000 and 2010. Nearly one-quarter of Hispanics aged 18 to 64 live below the federal poverty level, and 49% are uninsured. Several lifestyle factors lead to poor health behaviors in this community. Radio is a popular medium among Hispanic immigrants. The single local Spanish-language radio station reaches a large proportion of the local community and several communities beyond. Methods Through various methods, including workshops, review sessions, and other feedback mechanisms, we engaged stakeholders and community members in developing and evaluating a 48-episode radio novella to be broadcast as part of a variety show. We tracked participation of community members in all phases. Outcome Community members participated significantly in developing, broadcasting, and evaluating the intervention. The desired outcome — development of a culturally relevant storyline that addresses salient health issues and resonates with the community — was realized. Interpretation Our approach to community engagement can serve as a model for other organizations wishing to use community-based participatory methods in addressing Hispanic health issues. The radio novella was a unique approach for addressing health disparities among our community’s Hispanic population.

Reliability of the developmental eye movement test.

Purpose. This study evaluated the repeatability of the Developmental Eye Movement Test (DEM) with three consecutive administrations on two separate visits to 181 children between the ages of 6 years and 11 years 11 months. Methods. Children with visual acuity of ≥20/25, normal binocularity, and accommodation were administered three different versions of the DEM test. One to 4 weeks after the first administration of the DEM, the children were tested again using the same order for the three versions of the DEM. Measures of within- and between-session repeatability for the vertical-adjusted time, horizontal-adjusted time, ratio, and error scores were determined. Results. The within-session repeatability for vertical- and horizontal-adjusted time were good to excellent but were poor to good for ratio, and poor to fair for errors. The between-session intraclass correlation coefficients were fair to good for both the vertical and horizontal scores but poor for the ratio and error scores. The repeatability of the pass-fail diagnostic classification within a single session for each subject on test and retest was compared. The percentage of patients who remained in the same classification ranged from 71 to 100% for both vertical and horizontal scores. Wider variability was seen with the ratio and error scores showing between 47 and 100% of the children remaining classified as pass or fail with repeated administrations of the DEM. Such findings would suggest that children in this age range may show improvements in all four test scores without any intervention. Conclusions. Although the DEM is widely used in optometric practice, the results of this study suggest that clinicians should be cautious about using the DEM test in isolation for reaching a diagnosis or monitoring the effectiveness of treatment for saccadic dysfunction.

Use of Ready-made Spectacles to Meet Visual Needs in a Low-resource Adult Population

Purpose In affluent societies, distance and near vision problems are typically corrected with custom-made eyeglasses. Many persons in less affluent areas do not have the resources for such. The purpose of this study was to assess the use of less expensive ready-made (RM) bifocals and readers to correct distance and near refractive error and presbyopia in an outreach clinic in Nicaragua. Methods This is a retrospective review of records of all patients older than 34 years who presented for an eye examination in an outreach clinic in Granada, Nicaragua, in 2010. A visual satisfaction questionnaire had been administered to patients before they were examined and after RM plus sphere bifocals or plus sphere reading spectacles were dispensed. The main outcome measures included pre– and post–distance and near visual acuities, vision satisfaction and difficulty ratings, and perceived cost and willingness to pay for replacement rating. Results Ready-made plus sphere spectacles (bifocals or single-vision readers) were dispensed to 95.4% of those examined. The remaining 4.6% required custom prescriptions because of astigmatism, myopia, or anisometropia. The RM bifocals were very well accepted, with high visual satisfaction ratings with the bifocals improving from a presenting value of 11 to 89.4% at distance and from 6.6 to 89.4% at near. Percentage of patients achieving visual acuity of 20/40 or better improved from 60 to 84.5% at distance and from 44 to 97% at near. Percentage achieving functionally good near vision (20/40 or better) improved from 38 to 97% with RM readers. Patients reporting highest satisfaction with near vision improved from 6.3 to 86.6%. Patients indicated that, on average, they would be willing to pay US

Population-based study of presbyopia in Nicaragua.

18.39 to replace the bifocals and US

Exploring pre-school vision screening in primary care offices in Alabama.

16.67 to replace the readers. Conclusions Ready-made bifocals and RM single-vision readers may be an acceptable and affordable alternative for many patients with hyperopia and/or presbyopia where access to custom-made eyeglasses is difficult.