Marcia Daniels

Impaired natural killer cell activity during bereavement

Natural killer (NK) cell activity, a component of the immune surveillance system, was compared in women whose husbands had recently died with that found in age-matched women who had not experienced recent adverse life events. Bereaved women had significantly lower NK activity than women whose husbands were healthy. In a second study, depressive symptoms and NK activity were measured longitudinally in women before and after the death of their husbands. Our results suggest that depressive symptoms, not merely the death of the spouse, are related to a reduction in NK activity during bereavement.

Plasma cortisol and natural killer cell activity during bereavement

Natural killer cell (NK) activity, which is important in the defense against tumors and viral infections, is reduced in women undergoing conjugal bereavement. The relationship between NK activity and plasma cortisol was investigated in three groups of subjects: women who were anticipating the death of their husbands, women whose husbands had recently died, and controls. Bereaved women showed reduced NK activity and increased plasma cortisol levels as compared to controls. Anticipatory bereaved women also showed significant reductions in NK activity, but had levels of plasma cortisol comparable to those of controls. The reduction of NK activity during anticipatory and actual bereavement cannot be explained solely on the basis of increased cortisol secretion.

A structured interview version of the Hamilton Depression Rating Scale: Evidence of reliability and versatility of administration

A structured interview version of the Hamilton Depression Rating Scale (SI-HDRS) is described. Data are presented in support of its inter-rater and internal consistency reliability. SI-HDRS scores were reproducible by trained interviewers who lacked psychiatric backgrounds. Test-retest scores of a subset of patients who were interviewed twice (once in person and once by telephone) were highly correlated. Scores on the SI-HDRS did not differ between face-to-face and telephone administration groups, controlling for demographic factors, depression-specific indicators, and social and physical functioning. Since the SI-HDRS does not require a face-to-face interview by an experienced clinician, this instrument can be used economically in large-scale, community-based research projects.

A study of physician preferences in the management of depression in the general medical setting

Although more than 30% of ambulatory medical patients are depressed, little is known about how their depression is managed in the primary care setting. We surveyed 282 primary care physicians at two internal medicine and four family medicine programs. We asked these physicians to describe how they actually managed depression in their depressed medical patients and how they would manage ten hypothetical depressed medical patients. Demographic and attitudinal data were also obtained. Physicians reported that they utilized a wide variety of treatments for their depressed patients. They indicated that they would recommend counseling twice as many depressed patients as they would recommend medicating or referring. Over 30% of the variance in self-reported preferences to recommend particular treatments for depression was accounted for by physician characteristics. Prior experience with a treatment strategy was a significant factor in predicting a recommendation for future use of a treatment independent of other considerations such as endorsement of positive attitudes about the efficacy or benefits of a treatment. Prior experience was also more important than physician sociodemographics as a predictive variable. The clinical and educational implications of these findings for psychiatrists and primary care physicians are discussed.

Psychiatric consultation in a medical clinic: What do medical providers want?

A participant observation needs assessment of the use of a psychiatrist in a primary care medical setting was undertaken to quantify details of the interaction between a psychiatrist and primary care providers. Two hundred seventeen encounters involving 63 providers were recorded over a five and one-half month period. Utilization of the psychiatrist was widespread but skewed, with only 17% of the sample using 50% of the services. The mean number of encounters for all providers was 3.44. Consultation occurred mainly in a private area of the clinic, usually in an unplanned fashion. Only 21% of encounters involved seeing a patient. The range and content of these interactions was broad. Initial reasons for consultation were often redefined as the consultation ensued. The kinds of help most frequently requested involved discussing nonpsychopharmacologic treatments (35%), assisting providers with evaluations (31%), and exploring unresolved feelings about patients or patient care issues (29%). Slightly more than 50% of encounters required some type of follow-up. The findings suggest that psychiatrists who wish to work in primary care settings must have expertise in a multitude of areas and must be flexible in adapting themselves to the setting in which the primary care providers work.

Social and Structural Factors Affecting Psychiatric Consultation in the Ambulatory Medical Setting

The kinds of help primary care physicians requested from a psychiatric consultant in an ambulatory medical clinic are described. Based upon data from 173 encounters involving fifty-four physicians over a five and one-half month period, no single issue characterized a majority of encounters, and the nature of the help requested was diverse. Female physicians were more likely to initiate encounters that dealt with personal feelings about themselves or their patients. Male physicians were more likely to ask for assistance in evaluating patients. Whether or not a patient was seen as part of the consultation also significantly influenced the type of interaction that ensued as did the location of the interaction (hallway, room, or telephone) and whether or not the interaction was planned. Implications of these findings with regard to the training of primary care psychiatrists as well as the use of their services in ambulatory medical settings are explored.