Márcio Bezerra
Federal University of São Paulo
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Publication
Featured researches published by Márcio Bezerra.
The Neurologist | 2011
José Luiz Pedroso; Camila C. Aquino; Márcio Bezerra; Robson Fantinato Baiense; Marcelo Mendes Suarez; Lívia Almeida Dutra; Pedro Braga-Neto; Orlando Graziani Povoas Barsottini
Ginkgo biloba is a herbal medication that is often used worldwide. Although side effects are uncommon, G. biloba has been associated with serious bleeding complications, especially intracranial hemorrhage. We report the case of a young woman who made chronic use of G. biloba and suffered from cerebral bleeding without any structural abnormalities. Several studies have pointed to the association between G. biloba and intracranial hemorrhage.
Neurology India | 2011
Márcio Bezerra; Juliana Arita Harumi; Jullyanna Shinosaki; José Luiz Pedroso; Camila C. Aquino; Larissa Teles de Souza; Robson Fantinato Baiense; Acary Souza Bulle de Oliveira
The most frequent neurologic manifestations of hepatitis C virus infection include peripheral neuropathy axonal type and central nervous system (CNS) vasculitis. Affected patients usually have cryoglobulinemia and other signs of vasculitis. Demyelinating lesions, both central and peripheral are rarely described. We present a case of simultaneous peripheral nervous system and CNS demyelination that comes in relapsing episodes, with negative cryoglobulins.
Revista Brasileira de Psiquiatria | 2010
Flávio Alóe; Rosana Cardoso Alves; John Fontenele Araújo; Alexandre Azevedo; Andrea Bacelar; Márcio Bezerra; Lia Rita Azeredo Bittencourt; Guilherme Bustamante; Tania Aparecida Marchiori de Oliveira Cardoso; Alan Luiz Eckeli; Regina Maria França Fernandes; Leonardo Goulart; Márcia Pradella-Hallinan; Rosa Hasan; Heidi Haueisen Sander; Luciano Ribeiro Pinto; Maria Cecília Lopes; Gisele Richter Minhoto; Walter Moraes; Gustavo Antonio Moreira; Daniela Pachito; Mário Pedrazolli; Dalva Poyares; Lucila Bizari Fernandes do Prado; Geraldo Rizzo; R. Nonato Rodrigues; Israel Roitman; Silva Ademir Baptista; Stella Tavares
This manuscript contains the conclusion of the consensus meeting of the Brazilian Sleep Association with Brazilian sleep specialists on the treatment of narcolepsy based on the review of medical literature from 1980 to 2010. The manuscript objectives were to reinforce the use of agents evaluated in randomized placebo-controlled trials and to issue consensus opinions on the use of other available medications as well as to inform about safety and adverse effects of these medications. Management of narcolepsy relies on several classes of drugs, namely, stimulants for excessive sleepiness, antidepressants for cataplexy and hypnotics for disturbed nocturnal sleep. Behavioral measures are likewise valuable and universally recommended. All therapeutic trials were analyzed according to their class of evidence. Recommendations concerning the treatment of each single symptom of narcolepsy as well as general recommendations were made. Modafinil is the first-line pharmacological treatment of excessive sleepiness. Second-line choices for the treatment of excessive sleepiness are slow-release metylphenidate followed by mazindol. The first-line treatments of cataplexy are the antidepressants, reboxetine, clomipramine, venlafaxine, desvenlafaxine or high doses of selective serotonin reuptake inibitors antidepressants. As for disturbed nocturnal sleep the best option is still hypnotics. Antidepressants and hypnotics are used to treat hypnagogic hallucinations and sleep paralysis.
Arquivos De Neuro-psiquiatria | 2011
Pedro Braga-Neto; José Luiz Pedroso; André Carvalho Felício; Agessandro Abrahao; Lfvia Almeida Dutra; Márcio Bezerra; Orlando Graziani Povoas Barsottini
1. Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X. Fibromuscular dysplasia. Orphanet J Rare Dis 2007;2:28. 2. Slovut DP, Olin JW. Fibromuscular dysplasia. N Engl J Med 2004;350: 1862-1871. 3. Dayes LA, Gardiner N. The neurological implications of fibromuscular dys-plasia. Mt Sinai J Med 2005;72:418-420.4. Stahlfeld KR, Means JR, Didomenico P. Carotid artery fibromuscular dysplasia. Am J Surg 2007;193:71-72.5. Touze E, Oppenheim C, Trystram D, et al. Fibromuscular dysplasia of cervical and intracranial arteries. Int J Stroke 2010;5:296-305.
European Neurology | 2011
José Luiz Pedroso; Márcio Bezerra; Pedro Braga-Neto; Denise Spinola Pinheiro; Thais Minett; Gilmar Fernandes do Prado; Gilberto Mastrocola Manzano; Orlando Graziani Povoas Barsottini
Objective: To evaluate a group of spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) (SCA3/MJD) patients and assess whether there is an association between neuropathy and serum ferritin levels and restless legs syndrome (RLS). Methods: Twenty-six SCA3/MJD patients underwent electromyography studies to check for neuropathy. Their serum ferritin levels were measured as well. These findings were evaluated based on the presence or not of RLS and its severity. Results: The proportion of neuropathy in the RLS group was not significantly higher compared to the non-RLS group (23 vs. 15%, Fisher’s exact test, p = 1.000). Furthermore, no association was found between RLS and ferritin levels. Conclusion: We found no correlation between neuropathy or ferritin levels and RLS in SCA3/MJD patients.
Revista Brasileira de Psiquiatria | 2010
Flávio Alóe; Rosana Cardoso Alves; John Fontenele Araújo; Alexandre Azevedo; Andrea Bacelar; Márcio Bezerra; Lia Rita Azeredo Bittencourt; Guilherme Bustamante; Tânia Marchiori Cardoso; Alan Luiz Eckeli; Regina Maria França Fernandes; Leonardo Ierardi Goulart; Márcia Pradella-Hallinan; Rosa Hasan; Heidi Haueisen Sander; Luciano Ribeiro Pinto; Maria Cecília Lopes; Gisele Richter Minhoto; Walter Moraes; Gustavo Antonio Moreira; Daniela Pachito; Mário Pedrazolli; Dalva Poyares; Lucila Bizari Fernandes do Prado; Geraldo Rizzo; R. Nonato Rodrigues; Israel Roitman; Ademir Baptista Silva; Stella Tavares
This manuscript contains the conclusion of the consensus meeting on the diagnosis of narcolepsy based on the review of Medline publications between 1980-2010. Narcolepsy is a chronic disorder with age at onset between the first and second decade of life. Essential narcolepsy symptoms are cataplexy and excessive sleepiness. Cataplexy is defined as sudden, recurrent and reversible attacks of muscle weakness triggered by emotions. Accessory narcolepsy symptoms are hypnagogic hallucinations, sleep paralysis and nocturnal fragmented sleep. The clinical diagnosis according to the International Classification of Sleep Disorders is the presence of excessive sleepiness and cataplexy. A full in-lab polysomnography followed by a multiple sleep latency test is recommended for the confirmation of the diagnosis and co-morbidities. The presence of two sleep-onset REM period naps in the multiple sleep latency test is diagnostic for cataplexy-free narcolepsy. A positive HLA-DQB1*0602 with lower than 110pg/mL level of hypocretin-1 in the cerebrospinal fluid is required for the final diagnosis of cataplexy- and sleep-onset REM period -free narcolepsy.
The Cerebellum | 2014
José Luiz Pedroso; Edson Bor-Seng-Shu; Pedro Braga-Neto; Rodrigo Souza Ribeiro; Márcio Bezerra; Lucila Bizari Fernandes do Prado; Ilza Rosa Batista; Helena Alessi; Manoel Jacobsen Teixeira; Gilberto Mastrocola Manzano; Gilmar Fernandes do Prado; Orlando Graziani Povoas Barsottini
Spinocerebellar ataxia type 3 or Machado–Joseph disease is the most common spinocerebellar ataxia. In this neurological disease, anatomical, physiological, clinical, and functional neuroimaging demonstrate a degenerative process besides the cerebellum. We performed neurophysiological and neuroimaging studies—polysomnography, transcranial sonography, vestibular-evoked myogenic potential, single-photon emission computed tomography (SPECT) with 99mTc-TRODAT-1, and a formal neuropsychological evaluation in a patient with sleep complaints and positive testing for Machado–Joseph disease, without cerebellar atrophy, ataxia, or cognitive complaints. Polysomnography disclosed paradoxical high amplitude of submental muscle, characterizing REM sleep without atonia phenomenon. Transcranial sonography showed hyperechogenicity of the substantia nigra. There was an absence of vestibular-evoked myogenic potentials on both sides in the patient under study, in opposite to 20 healthy subjects. Brain imaging SPECT with 99mTc-TRODAT-1 demonstrated a significant lower DAT density than the average observed in six healthy controls. Electroneuromyography was normal. Neuropsychological evaluation demonstrated visuospatial and memory deficits. Impairment of midbrain cholinergic and pontine noradrenergic systems, dysfunction of the pre-synaptic nigrostriatal system, changes in echogenicity of the substantia nigra, and damage to vestibulo-cervical pathways are supposed to occur previous to cerebellar involvement in Machado–Joseph disease.
Parkinsonism & Related Disorders | 2013
José Luiz Pedroso; Alzira Alves Carvalho; Márcio Bezerra; Pedro Braga-Neto; Agessandro Abrahao; Marcus Vinicius Cristino Albuquerque; Maria Luiza Saraiva-Pereira; Laura Bannach Jardim; Francisco Cardoso; Orlando Graziani Povoas Barsottini
Spinocerebellar ataxias (SCA) are a group of neurodegenerative diseases that may affect the cerebellum and its connections. Although the clinical spectrum of SCA is mostly characterized by progressive cerebellar ataxia, phenotypic variability has often been reported. Moreover, a wide range of non-ataxia features can be observed during disease progression. Among non-ataxia features, several types of movement disorders may be found in SCA, and are not uncommon [1]. Almost all types of movement disorders can be detected in patients with SCA, and may be related to basal ganglia involvement. Up to this moment, 36 subtypes of SCA are known. The most common related movement disorders with SCA subtype are: myoclonus in SCA2 and SCA14; dystonia in SCA2, SCA3 and SCA17; eyelid dystonia in SCA3; chorea in SCA3 and SCA17; parkinsonism in SCA2, SCA3 and SCA17; akathisia in SCA3; action tremor SCA12 and SCA27; palatal tremor in SCA20 [1–4]. Thus, the observed movement disorder, when present in combination with cerebellar ataxia, could point to the underlying SCA. Conversely, some patients with SCA may present with complex and unusual movement disorders. Herein, we describe four patients presenting with unusual movement disorders in three different subtypes of SCA. We also comment on phenomenology and underlying pathophysiology involved.
European Neurology | 2013
Márcio Bezerra; José Luiz Pedroso; Denise Spinola Pinheiro; Pedro Braga-Neto; Orlando Graziani Povoas Barsottini; Nadia Iandoli de Oliveira Braga; Gilberto Mastrocola Manzano
Objective: Neuropathy is a well-recognized feature in spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD), but the pattern of neuropathy is still a matter of debate. This study aimed to evaluate peripheral nerve involvement in MJD patients. Neurophysiological and clinical data were analyzed to distinguish neuronopathy from length-dependent distal axonopathy. Methods: In the present study we evaluated 26 patients with clinical and molecular-proven MJD and investigated their peripheral nerve involvement. Neurophysiological and clinical data were compared and correlated aiming to distinguish neuronopathy from distal axonopathy. Results: The neurophysiological evaluation showed that 42.3% of the patients had polyneuropathy. Among these patients, 81.8% presented neuronopathy. Conclusion: We concluded that neuronopathy is the most common form of peripheral nerve involvement in MJD patients.
Arquivos De Neuro-psiquiatria | 2002
José Augusto Nasser; Asdrubal Falavigna; Márcio Bezerra; Victor Martinez; Gabriel Rodrigues de Freitas; Armando Alaminos; Antonio de Pádua Furquim Bonatelli; Fernando Antonio Patriani Ferraz
PURPOSE The authors present a prospective study on 10 patients with stereotactic infusion of tissue plasminogen activator (rtPA) intraparenchimal hemorrhage. METHODS Between 1999 and 2000, 10 patients with deep seated hematomas in the basal ganglia were selected for stereotactic infusion of rtPA and spontaneous clot drainage. RESULTS All cases had about 80% reduction of the hematoma volume in the CT scan at the third day. The intracranial pressure was normalized by the third day too. There were no local or systemic complications with the use of this thrombolytic. The results were shown by the Glasgow Outcome Scale with six patients in V, three in IV and one in III after 3 months. CONCLUSION Early treatment and drainage with minimally invasive neurosurgery, can make these patients with deep-seated hematomas recover the consciousness and they can be rehabilitated earlier avoiding secondary complications.