Márcio Campos Oliveira

HPV e carcinogênese oral: revisão bibliográfica

The human papillomavirus (HPV) is a epitheliotropic ubiquitous DNA virus and which has as main infection sites the skin and the mucosas. Lately, its association with benign and malignant neoplasias of oral cavity mainly the squamous cell carcinoma has been more evident. Its common finding in normal oral mucosa epithelium largely publicated in literature doesnt allow inferences more accurate in relation to its role in carcinogenesis (if main or coadjuvant etiological agent or simple covering epithelium inhabitant of oral mucosa). They are already more than 100 types identified which 24 were already located in oral cavity. Of these, 4 are particularly important, the HPVs types 6 and 11 (which are involved in benign lesions of oral epithelium), 16 and 18 (proved carcinogenics and possibly involved in the etiology of determined oral squamous cell carcinomas). The action of these two last types is mainly associated to the E6 and E7 oncoproteins produced by themselves. The E6 binds, sequestrates and degrades the p53, an important tumour supressor protein. The second binds and sequestrates the pRb, also tumour supressor, facilitating the release of E2F. In spite of the refinement HPV detection techniques in oral mucosa lesions, its direct involvement with the oral carcinomas wasnt still duly proved, however, in our opinion, the association of virus with chemical and physical carcinogens in some squamous cell carcinomas, such as the tobacco and alcohol, may represents a plausible explanation regarding the role of human papillomavirus in oral carcinogenesis.

Óbito em caso de leishmaniose cutâneomucosa após o uso de antimonial pentavalente

The authors report a case of mucocutaneous leishmaniasis in a 45-year-old patient who was unsuccessfully treated with pentavalent antimonial for 30 days. After 10 days from the initial treatment and before starting a new therapeutic regimen with the same drug the patient died due to sudden cardiac arrest.

Epidemiology of HPV in Head and Neck Cancer

The Human papillomavirus (HPV) is etiologically related to the development of uterine cervical and other genital cancers (Bosch et al., 1995; Frisch et al., 1999; Melbye & Frisch, 1998), and may be involved also in the etiology of cancers of the upper aerodigestive tract comprising the head and neck (HN) tumors (Franceschi et al., 1996). Some molecular and epidemiological studies support such possibility, once that an increased risk of cancer of the oral cavity, pharynx and larynx subsequent to the occurrence of cancer of the cervix has been found. Moreover, the incidence of some head and neck tumors has been increasing around the world and this high prevalence was attributed to the influence of risk factors, being the human papillomavirus important in this role.

Exposição a fluoreto por crianças na faixa etária crítica para fluorose dentária, residentes no semiárido brasileiro

There is a concern about the increasing prevalence of dental fluorosis, which depends on the dose of fluoride (F) to which children are subjected during tooth formation. Environmental temperature affects water intake and therefore it would be important to assess whether children living in the semiarid region are exposed to an excessive dose of F. Therefore, the objective of this study was to determine the total dose of F to which children are exposed during the critical age for dental fluorosis, with diet (water and food) and toothpaste as F sources, in the semiarid region of Brazil.nnnMETHODOLOGYn26 children aged 25.2 ± 9.1 months, residents in Feira de Santana, State of Bahia (with F in the public water supply) were selected. Duplicate-diet, water, products from toothbrushing and toothpaste samples were collected. F concentration was determined using an ion-specific electrode, after proper sample preparation.nnnRESULTSnthe mean and standard deviation of dose (mg F/kg/day) from diet, toothpaste and total were respectively: 0.016 ± 0.010; 0.030 ± 0.039 and 0.047 ± 0.043.nnnCONCLUSIONSnthe children evaluated living in the semiarid region are not exposed to a risk dose for dental fluorosis.