Marco Antonio Barbosa-Mireles

Evaluation of clinical and immunopathological features of different infective doses of Trypanosoma cruzi in dogs during the acute phase

Infection with Trypanosoma cruzi is a major risk in Latin America, and dogs are believed to be good models for evaluating Chagas disease. Here, we evaluated the clinical and immunopathological alterations developed by mongrel dogs experimentally infected with different infective doses (2,000, 20,000, and 200,000 metacyclic trypomastigotes of Sylvio X10/4 strain kg−1 via intraperitoneal). Clinical and electrocardiographic parameters, as well as antibody production and pathologic lesions were evaluated. All three doses of this strain of T. cruzi induced a similar pattern of infection characterized by cardiac arrhythmias and severe and diffuse myocarditis. Specific anti-T. cruzi IgG indicated seroconversion by day 14 after infection, and IgG levels increased during the period of evaluation. Mortality was observed only in dogs infected with the medium or high parasite doses, but not in the group infected with a low dose of 2,000 parasites kg−1. Infection with a low dose of parasites provides an excellent nonlethal model to evaluate the immunopathology of the acute disease in dogs infected with the Sylvio X10/4 strain of T. cruzi.

INTERMITTENT GASTROESOPHAGEAL INTUSSUSCEPTION IN A KITTEN RESOLVED WITH A PERCUTANEOUS GASTROPEXY

Abstract Gastroesophageal intussusception is a rare pathology characterized by an acute or intermittent invagination of the stomach into the lumen caudal to the thoracic esophagus, the pathogenesis is not well understood, although it is likely multifactorial. The mortality is high, associated with a late diagnosis and a rapid deterioration. A 4-month-old male domestic shorthair kitten presented for evaluation of intermittent respiratory distress and abdominal discomfort with two weeks of evolution. Based on clinical history, clinical sings and imaging studies a diagnosis of intermittent gastroesophageal intussusception was established. The reduction of the intussusception was performed with endoscopy maneuvers and with medical and nutritional management for some days, but this failed and finally was reduced with a percutaneous gastropexy tube to prevent recurrence with a good long-term outcome. Gastroesophageal intussusception in cats is associated with megaesophagus or hiatal hernia, and should be considered as a differential diagnosis in patients with chronic vomiting, regurgitation or respiratory disease. Survey and contrasted thoracic radiographs can be used to identify gross anatomical abnormalities, but the definitive diagnosis should be made by esophagogastroscopy with the possibility of reducing the intussusception. The use of percutaneous gastropexy provides other possible option to conventional surgery for the management of this pathology in cats.

Respuesta del Tumor Venéreo Transmisible Canino a Presentaciones de Vincristina de Patente y Genérica

The aim of this study was to compare the response of naturally infected dogs with transmissible venereal tumor (TVT) to treatment with two sources of vincristine: patented and generic. Twelve naturally infected dogs diagnosed with TVT by cytology and PCR

Atresia anal en perros y gatos: conceptos actuales a partir de tres casos clínicos

Anal atresia is defined as the lack of a complete communication between rectum and the anus, it is the most common anorectal malformation and has been observed mainly in dogs. It has been associated to alterations of anogenital differentiation of the cloaca in the embryo, however, the exact mechanisms remain unclear. Different criteria have been proposed in the literature to classify anal atresia. This study shows the diagnosis, treatment and outcome of three cases (two dogs and one cat) with anal atresia. The frequency of this malformation in our hospital is reported as well as a discussion of the theories of the processes involved in the development of anal atresia, and a revised classification for this pathology according to embryo anatomy and development is proposed.