Marco Aurélio Lana Peixoto

Contribuição do Mismatch Negativity na avaliação cognitiva de indivíduos portadores de esclerose múltipla

Mismatch Negativity is a functional index of the supratemporal auditory cortex. AIM: The aim of the present study on Mismatch Negativity (MMN) in multiple sclerosis (MS) patients was to evaluate if the MMN can be correlated with cognitive deficits assessed by the Paced Auditory Addition Task - PASAT. METHOD: a clinical study in forty females and 20 males separated in two groups: control individuals and those with a definite diagnosis of MS underwent a duration and frequncy MMN. The MMN latencies and negative amplitudes obtained from the MS group were compared to the ones from the control group. The scores from the Paced Auditory Addition Task were correlated either with the presence or the absence of MMN. RESULTS: MMN was found in 60% of the individuals with multiple sclerosis within the auditory stimulation protocol with varied durations, and in 45 % within the auditory stimulation protocol with frequency variations. There were no statistically significant differences in latencies and amplitudes when compared to controls. We found a statistically significant correlation for the lack of MMN wave together with cognitive disorder asserted by the PASAT. CONCLUSIONS: The MMN correlated to the cognitive deficit assessed by the PASAT.

Avaliação dos potenciais evocados auditivos do tronco encefálico na esclerose múltipla

The aim of this study was to evaluate the incidence of auditory and neurotological disorders in multiple sclerosis (MS). Twenty female and 9 male with a definite diagnosis of multiple sclerosis without signs of involvement of the brain stem underwent an audiological and an early auditory evoked potentials (EAEP). The wave forms were classified according to Jergers (1986) classification. In 58 EAEP it was found 55% of type I (normal response) according to Jergers classification in both sexes. Considering as an abnormal response the EAEP classified in type II, III, IV or V according to Jerger in at least one side, it was found 60% of abnormalities in females and 56% in males, totalizing 58,62% of all the studied subjects. The authors emphasize the use of EAEP in MS.The aim of this study was to evaluate the incidence of auditory and neurotological disorders in multiple sclerosis (MS). Twenty female and 9 male with a definite diagnosis of multiple sclerosis without signs of involvement of the brain stem underwent an audiological and an early auditory evoked potentials (EAEP). The wave forms were classified according to Jergers (1986) classification. In 58 EAEP it was found 55% of type I (normal response) according to Jergers classification in both sexes. Considering as an abnormal response the EAEP classified in type II, III, IV or V according to Jerger in at least one side, it was found 60% of abnormalities in females and 56% in males, totalizing 58,62% of all the studied subjects. The authors emphasize the use of EAEP in MS.

Mismatch Negativity contribution in Multiple Sclerosis patients

UNLABELLED Mismatch Negativity is a functional index of the supratemporal auditory cortex. AIM The aim of the present study on Mismatch Negativity (MMN) in multiple sclerosis (MS) patients was to evaluate if the MMN can be correlated with cognitive deficits assessed by the Paced Auditory Addition Task--PASAT. METHOD a clinical study in forty females and 20 males separated in two groups: control individuals and those with a definite diagnosis of MS underwent a duration and frequency MMN. The MMN latencies and negative amplitudes obtained from the MS group were compared to the ones from the control group. The scores from the Paced Auditory Addition Task were correlated either with the presence or the absence of MMN. RESULTS MMN was found in 60% of the individuals with multiple sclerosis within the auditory stimulation protocol with varied durations, and in 45 % within the auditory stimulation protocol with frequency variations. There were no statistically significant differences in latencies and amplitudes when compared to controls. We found a statistically significant correlation for the lack of MMN wave together with cognitive disorder asserted by the PASAT. CONCLUSIONS The MMN correlated to the cognitive deficit assessed by the PASAT.

Estudos Clínicos Iniciais com o Teste de Discriminação de Listas (TDL-UFMG)

Prefrontal cortex-related circuits are important to several executive functions, including serial organization of behavior. Serial organization of memory was investigated by means of a list discrimination task. During stimulus presentation, two lists of ten stimuli each (ten concrete word or ten line drawings of objects) were presented before and after a distracter task. In the testing phase, 20 pairs of stimuli were presented one by one. One of the stimuli in the pair was new and the other had already been presented. Participants should recognize the old stimulus and determine the list where it appeared before (temporal order judgment). We report on initial clinical investigations suggesting that the task may be useful to differentiate between young adults and older subjects, and these from patients with frontal lobe pathology, multiple sclerosis as well as psychiatric patients. All groups of patients, as well as aged subjects, showed performance dissociation with normal recognition and altered serial ordering in memory.

Leopard syndrome, a neural crest disorder: a case report

A case of Leopard syndrome with full clinical expression is reported. In addition to the cardinal signs of the syndrome this patient presented some abnormalities which have not been previously described such as macroglossia, multiple dental anomalies, basilar impression and platybasia, megacolon, hypertrophy of clitoris and anal ectopy. The presence of dental anomalies and megacolon may represent involvement of the dental papillae and myenteric plexus favoring the view that the syndrome results from a derangement of the neural crest elements.