Marco Paganini
University of Florence
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Featured researches published by Marco Paganini.
Journal of Neuroimmunology | 2008
Sabrina Matà; Gian Carlo Muscas; Ilaria Naldi; Eleonora Rosati; Sergio Paladini; Barbara Cruciatti; Francesca Bisulli; Marco Paganini; Gustavo Mazzi; Sandro Sorbi; Paolo Tinuper
Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders. Here we have characterized the clinical and laboratory features of two patients presenting with subacute onset, and chronic evolution, of anterograde amnesia and drug-resistant epilepsy associated with thyroid autoimmunity and in absence of tumoral pathology despite long follow-up. Antibodies against onconeural antigens, voltage gated potassium channel and glutamate receptors, which may accompany paraneoplastic as well as non-paraneoplastic LE, were negative. However, biochemical studies showed high titers, and sustained intrathecal synthesis, of antibodies directed against neuronal glutamic acid decarboxylase (GAD). In one patient, plasma exchange determined a dramatic improvement of the neurological deficits along with the decrease of autoantibodies.
Neuropsychobiology | 1997
Roberta Chiaramonti; Gian Carlo Muscas; Marco Paganini; Müller Tj; Andreas J. Fallgatter; A. Versari; Werner Strik
Quantitative electroencephalography (qEEG) and the Folstein Mini Mental State examination (MMSE) were obtained from 31 patients affected by probable dementia of Alzheimers type (DAT). qEEG data were examined both by spectral analysis (Fast Fourier Transformation) and by single frequency band topographical centroid, and compared with those of 24 healthy subjects of the same age group. DAT patients were found to have higher absolute power in the slow (delta and theta) frequency bands. Quantitative topographical assessment showed significantly more anteriorly located centers of gravity for the alpha and beta activity. Only alpha anteriorization was correlated with the degree of cognitive impairment as measured by the global deterioration scale and MMSE. It is concluded that quantitative topographical assessment was successful for the statistical handling of the EEG power maps, and to identify a potential parameter for the functional staging of the disease.
Experimental Neurology | 2010
Pasquale Gallina; Marco Paganini; Letizia Lombardini; Mario Mascalchi; Berardino Porfirio; Davide Gadda; Mirca Marini; Pamela Pinzani; Francesca Salvianti; Clara Crescioli; Sandra Bucciantini; Claudia Mechi; Erica Sarchielli; Anna Maria Romoli; Elisabetta Bertini; Serena Urbani; Benedetta Bartolozzi; Maria Teresa De Cristofaro; Silvia Piacentini; Riccardo Saccardi; Alberto Pupi; Gabriella Barbara Vannelli; Nicola Di Lorenzo
Rebuilding brain structure and neural circuitries by transplantation of fetal tissue is a strategy to repair the damaged nervous system and is currently being investigated using striatal primordium in Huntingtons disease (HD) patients. Four HD patients underwent bilateral transplantation with human fetal striatal tissues (9-12 week gestation). Small blocks of whole ganglionic eminencies were processed to obtain cell suspension and then stereotactically grafted in the caudate head and in the putamen. Follow-up period ranged between 18 and 34 months (mean, 24.7 months). Surgery was uneventful. Starting from the fourth month after grafting, neo-generation of metabolically active tissue with striatal-like MRI features was observed in 6 out of 8 grafts. The increase in D2 receptor binding suggested striatal differentiation of the neo-generated tissue in 3 patients. New tissue, connecting the developing grafts with the frontal cortex and, in one case, with the ventral striatum, was also observed. The new tissue growth halted after the ninth month post transplantation. All patients showed stabilization or improvement in some neurological indices. No clinical and imaging signs, suggestive of graft uncontrolled growth, were seen. This study provides the first evidence in humans that neuroblasts of a striatal primordium can develop and move into the brain after neurotransplantation. Primordium development resulted in the building of a new structure with the same imaging features as the corresponding mature structure, combined with short- and long-distance targeted migration of neuroblasts. The results of this study support both the reconstructive potential of fetal tissue and the remarkably retained plasticity of adult brain. Further studies are necessary to assess the clinical efficacy of the human fetal striatal transplantation.
Neurological Sciences | 2000
Sandro Sorbi; Margherita Alberoni; Pasquale Alfieri; Serena Amici; Daniele Antana; Ildebrando Appollonio; Stefano Avanzi; Antonella Bartoli; B. Bergamasco; Laura Bracco; Amalia C. Bruni; Orso Bugiani; Paolo Caffarra; Carlo Caltagirone; Antonio Carolei; Anna De Rosa; Luciana Ciannella; Antonietta Citterio; Antonio Daniele; Graziella D'Achille; Giuseppe Del Curatolo; Grazia Dell'Agnello; Daniele Durante; Elisabetta Farina; Patrizia Ferrero; Paolo Forleo; Guido Gainotti; Paolo Gabriele; Emanuela Galante; Virgilio Gallai
SIN DOCUMENT*The Dementia Study Group is co-ordinated by Sandro Sorbi andincludes: Margherita Alberoni, Milan; Pasquale Alfieri, SommaVesuviana (NA); Serena Amici, Perugia; Daniele Antana, Rome;Ildebrando Appollonio, Monza (MI); Stefano Avanzi,Castelgoffredo (MN); Antonella Bartoli, Pescara; BrunoBergamasco, Turin; Laura Bracco, Florence; Amalia Bruni,Lamezia Terme (CZ); Orso Bugiani, Milan; Paolo Caffarra, Parma;Carlo Caltagirone, Rome; Antonio Carolei, L’Aquila; Anna RosaCasini, Rome; Luciana Ciannella, Benevento; Antonietta Citterio,Pavia; Antonio Daniele, Rome; Graziella D’Achille, Isernia;Giuseppe Del Curatolo, Grosseto; Grazia Dell’Agnello, Pisa;Daniele Durante, Parma; Elisabetta Farina, Milan; Patrizia Ferrero,Turin; Paolo Forleo, Florence; Guido Gainotti, Rome; PaoloGabriele, Cassino (FR); Emanuela Galante, Castelgoffredo (MN);Virgilio Gallai, Perugia; Roberto Gallassi, Bologna; MaddalenaGasparini, Milan; Bernardino Ghetti, Indianapolis (USA); GiorgioGiaccone, Milan; Floriano Girotti, Milan; Luigi Grimaldi, Milanand Caltanisetta; Serenella Grioli, Catania; Bianca MariaGuarnieri, Pescara; Stefano Grottoli, Fossombrone (PS); FrancescoIemolo, Ragusa; Stefania Latorraca, Florence; Francesco Le Pira,Catania; Gian Luigi Lenzi, Rome; Sebastiano Lorusso, Rimini;Claudio Mariani, Milan; Gabriella Marcon, Udine; VincenzoMascia, Carbonia (CA); Simonetta Mearelli, L’Aquila; MariaMorante, Senigallia (AN); Michela Morbin, Milan; MassimoMusicco, Segrate (MI); Ettore Nardelli, Verona; Paolo Nichelli,Modena; Alessandro Padovani, Brescia; Marco Paganini, Florence;Roberta Pantieri, Bologna; Pietro Parisen, Vicenza; LucillaParnetti, Perugia; Bruno Passerella, Brindisi; Carla Pettenati, Rho(MI); Silvia Piacentini, Florence; Federico Piccoli, Palermo; CarloPiccolini, Perugia; Gilberto Pizzolato, Padova; LeandroProvinciali, Ancona; Nicola Pugliese, Salerno; Francesco Redi,Arezzo; Rosa Maria Ruggieri, Palermo; Umberto Ruggiero,Naples; Marco Saetta, Siracusa; Rudolf Schoenuber, Bolzano;Maria Caterina Silveri, Rome; Sandro Sorbi, Florence; GiuseppeSorrentino, Naples; Patrizia Sucapane, L’Aquila; Andrea Stracciari,Bologna; Massimo Tabaton, Genova; Fabrizio Tagliavini, Milan;Vito Toso, Vicenza; Francesco Valluzzi, Putignano Noci (BA)S. Sorbi ( )Department of Neurological and Psychiatric SciencesUniversity of FlorenceViale Morgagni 85, I-50131 Florence, Italy
Neuroradiology | 1998
Mario Mascalchi; Mirco Cosottini; M. Cellerini; Marco Paganini; Graziano Arnetoli
Abstract MRI demonstrated well-defined areas of signal change and moderate contrast enhancement in the thoracic spinal cord of a patient with Behçets disease presenting with subacute myelopathy. The patient improved after intravenous steroids, and MRI 5 months later showed a normal spinal cord.
Journal of Neurology, Neurosurgery, and Psychiatry | 2014
Marco Paganini; Annibale Biggeri; Anna Maria Romoli; Claudia Mechi; Elena Ghelli; Valentina Berti; Silvia Pradella; Sandra Bucciantini; Dolores Catelan; Riccardo Saccardi; Letizia Lombardini; Mario Mascalchi; Luca Massacesi; Berardino Porfirio; Nicola Di Lorenzo; Gabriella Barbara Vannelli; Pasquale Gallina
Objective To assess the clinical effect of caudate-putaminal transplantation of fetal striatal tissue in Huntingtons disease (HD). Methods We carried out a follow-up study on 10 HD transplanted patients and 16 HD not-transplanted patients. All patients were evaluated with the Unified HD Rating Scale (UHDRS) whose change in motor, cognitive, behavioural and functional capacity total scores were considered as outcome measures. Grafted patients also received morphological and molecular neuroimaging. Results Patients were followed-up from disease onset for a total of 309.3 person-years (minimum 5.3, median 11.2 years, maximum 21.6 years). UHDRS scores have been available since 2004 (median time of 5.7 years since onset, minimum zero, maximum 17.2 years). Median post-transplantation follow-up was 4.3 years, minimum 2.8, maximum 5.1 years. Adjusted post-transplantation motor score deterioration rate was reduced compared to the pretransplantation period, and to that of not-transplanted patients by 0.9 unit/years (95% CI 0.2 to 1.6). Cognitive score deterioration was reduced of 2.7 unit/years (95% CI 0.1 to 5.3). For grafted patients the 2-year post-transplantation [18F]fluorodeoxyglucose positron emission tomography (PET) showed striatal/cortical metabolic increase compared to the presurgical evaluation; 4-year post-transplantation PET values were slightly decreased, but remained higher than preoperatively. [123I]iodobenzamide single photon emission CT demonstrated an increase in striatal D2-receptor density during postgrafting follow-up. Conclusions Grafted patients experienced a milder clinical course with less pronounced motor/cognitive decline and associated brain metabolism improvement. Life-time follow-up may ultimately clarify whether transplantation permanently modifies the natural course of the disease, allowing longer sojourn time at less severe clinical stage, and improvement of overall survival.
Neurological Sciences | 2003
P. Marini; Silvia Ramat; Andrea Ginestroni; Marco Paganini
Abstract.We assessed the effect of pathology and L-dopa therapy on attention, working memory, and executive functions, in newly diagnosed Parkinson’s disease patients. Twenty-one consecutive outpatients who met the criteria for de novo Parkinson’s disease, and were naive for L-dopa therapy, were observed for the first time. All patients underwent clinical and neuropsychological evaluations (cognitive decline, memory, executive control). Each patient was reevaluated on standard L-dopa therapy. Serial Position Curves showed an increased primacy effect (5.18±2.07) and a decreased recency effect (13.35±5.51). These findings normalized after L-dopa therapy (3.50±1.72 and 16.20±3.09 respectively). The effect of L-dopa on working memory is discussed.
Neurology | 1984
Gaetano Zaccara; Roberto Campostrini; Marco Paganini; Flavio Moroni; Tommaso Valenza; Giacomo Targioni; Graziano Arnetoli; R. Zappoli; Agostino Baruzzi
Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepileptic drugs. A standardized loading dose of VPA was administered, and venous blood was sampled at 0,1,2,3, and 4 hours. Ammonia (NH,) was higher in patients who, during continuous therapy, complained of drowsiness (7 patients) than in those who were symptom-free (17 patients), although VPA plasma levels were similar in both groups. By measuring VPA-induced changes of blood NH3, content, it may be possible to identify patients at higher risk of obtundation when VPA is given chronically.
Experimental Neurology | 2014
Erica Sarchielli; Mirca Marini; Stefano Ambrosini; Alessandro Peri; Benedetta Mazzanti; Pamela Pinzani; Emanuela Barletta; Lara Ballerini; Ferdinando Paternostro; Marco Paganini; Berardino Porfirio; Annamaria Morelli; Pasquale Gallina; Gabriella Barbara Vannelli
Grafting fetal striatal cells into the brain of Huntingtons disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striatum during development when the progenitor cells, isolated from their environment, are able to maintain regional-specific-identity and to respond appropriately to cues. The primary cell culture from human fetal striatal primordium described here consists of a mixed population of neural stem cells, neuronal-restricted progenitors and striatal neurons. These cells express trophic factors, such as BDNF and FGF2. We show that these neurotrophins maintain cell plasticity, inducing the expression of neuronal precursor markers and cell adhesion molecules, as well as promoting neurogenesis, migration and survival. We propose that BDNF and FGF2 play an important autocrine-paracrine role during early striatum development in vivo and that their release by fetal striatal grafts may be relevant in the setting of HD cell therapy.
Alzheimers & Dementia | 2016
Emilia Salvadori; Anna Poggesi; Raffaella Valenti; Giovanni Pracucci; Francesca Pescini; Marco Pasi; Serena Nannucci; Sandro Marini; Alessandra Del Bene; Laura Ciolli; Andrea Ginestroni; Stefano Diciotti; Giovanni Orlandi; Ilaria Di Donato; Nicola De Stefano; Mirco Cosottini; Alberto Chiti; Antonio Federico; Maria Teresa Dotti; Ubaldo Bonuccelli; Domenico Inzitari; Leonardo Pantoni; Rosanna Abbate; Maria Boddi; Francesca Cesari; Mirella Coppo; Betti Giusti; Anna Maria Gori; Mario Mascalchi; Paolo Cecchi
Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile.