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Archive | 2001

The Fc receptor family structure based strategies for the development of anti-inflammatory drugs

P. Mark Hogarth; Maree S. Powell; Lisa J. Harris; Bruce David Wines; Gary P. Jamieson

Summary. Leukocyte Fc receptors play key roles in the initiation of antibodyxad mediated cellular responses to pathogens. However, they are also involved in the pathogenesis of destructive immune complex inflammatory diseases. The solving of the FcR crystallographic structures together with molecular modelling has provided an opportunity to examine closely the mode of interaction between receptor and ligand. Also such work has allowed the design of novel antixad inflammatory agents that act to block receptor:ligand interactions. These are potentially effective therapeutic agents in the treatment of immune complex mediated inflammatory diseases.


Blood | 2008

Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing Fc RIIa

Elizabeth E. Gardiner; Denuja Karunakaran; Jane F. Arthur; Fi-Tjen Mu; Maree S. Powell; Ross Baker; Phillip Mark Hogarth; Mark L. Kahn; Robert K. Andrews; Michael C. Berndt


Archive | 1999

THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF

P. Mark Hogarth; Maree S. Powell; Ian Farquhar Campbell Mckenzie; Kelly F. Maxwell; Thomas P. J. Garrett; Vidana Epa


Archive | 1999

Fc receptor modulators and uses thereof

Jonathan B. Baell; Thomas P. J. Garrett; P. Mark Hogarth; Barry Ross Matthews; Tom McCarthy; Geoffrey Allan Pietersz; Maree S. Powell; Ian Farquhar Campbell Mckenzie; Kelly F. Maxwell; Vidana Epa


Archive | 1995

POLYPEPTIDES WITH Fc BINDING ABILITY

Phillip Mark Hogarth; Ian Farquhar Campbell Mckenzie; Ross Baker; Mark D. Hulett; Maree S. Powell


Archive | 1999

Structure-based identification of candidate compounds using three dimensional structures and models of Fc receptors

P. Mark Hogarth; Maree S. Powell; Ian Farquhar Campbell Mckenzie; Kelly F. Maxwell; Thomas P. J. Garrett; Vidana Epa


Archive | 2013

Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: De-ITAM-ising FcγRIIa Running Title: Platelet receptor regulation

Elizabeth E. Gardiner; Denuja Karunakaran; Jane F. Arthur; Fi-Tjen Mu; Maree S. Powell; Ross Baker; P. Mark Hogarth; Mark L. Kahn; Robert K. Andrews; Michael C. Berndt


Archive | 2013

platelet receptors: de-ITAM-izing Fc Dual ITAM-mediated proteolytic pathways for irreversible inactivation of

Mark L. Kahn; Robert K. Andrews; Michael C. Berndt; Elizabeth E. Gardiner; Jane F. Arthur; Fi-Tjen Mu; Maree S. Powell


Archive | 1999

STRUCTURES TRIDIMENSIONNELLES ET MODELES DE RECEPTEURS Fc, ET LEURS UTILISATIONS

P. Mark Hogarth; Maree S. Powell; Ian Farquhar Campbell Mckenzie; Kelly F. Maxwell; Thomas P. J. Garrett; Vidana Epa; Jonathan B. Baell; Barry Ross Matthews; Tom McCarthy; Geoffrey Allan Pietersz


Archive | 1999

DREIDIMENSIONALE STRUKTUREN UND MODELLE VON Fc-REZEPTOREN UND IHRE VERWENDUNGEN.

P. Mark Hogarth; Maree S. Powell; Ian Farquhar Campbell Mckenzie; Kelly F. Maxwell; Thomas P. J. Garrett; Vidana Epa; Jonathan B. Baell; Barry Ross Matthews; Tom McCarthy; Geoffrey Allan Pietersz

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Thomas P. J. Garrett

Walter and Eliza Hall Institute of Medical Research

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