Marek Synder

The role of the acetabulum in perthes disease

Abstract: The purpose of this study is to evaluate the changes in the shape of acetabulum from the onset of the disease to the skeletal maturity in Legg-Calvé-Perthes disease. The study population consisted of 243 patients with unilateral involvement who had reached skeletal maturity at last follow-up. All hips were treated by containment methods (which included bed rest and traction in abduction, Petri cast, brace, varus osteotomy, Salter osteotomy, and shelf acetabuloplasty). Necrosis of the femoral head was estimated according to the lateral pillar classification and late results according to the Stulberg classification. Changes in the shape of the acetabulum were divided into 3 groups: type I-normal, concave lateral acetabulum margin; type II-flat, horizontal lateral acetabulum margin; and type III-convex, sloping acetabular margin. Roentgenograms performed during the fragmentation stage revealed type I changes in 78 (32.1%) hips, type II in 136 (55.7%), and type III in 29 (12.2%). At the last follow-up, there were type I changes in 124 (51.2%) hips, type II in 81 (33.5%), and type III in 38 (15.3%). The statistical analysis revealed no significant statistical difference between the age at the onset and gender with regard to acetabular changes. There was significant statistical correlation between the lateral pillar classification, subluxation of the femoral head, the range of hip abduction, and the Stulberg classification with regard to acetabular changes. A type III was statistically associated with lateral pillar classification group C, major subluxation of the femoral head, limited hip abduction, and in Stulberg group 3, 4, or 5. Only surgical methods of treatment improved the acetabular shape at the last follow-up (P < 0.05). In our opinion, the lateral acetabulum shape plays a very important role during the remodeling of the deformed proximal femoral epiphysis.

Function of the rabbit supraspinatus muscle after detachment of its tendon from the greater tubercle. Observations up to 6 months.

The supraspinatus tendon was detached from the greater tubercle in 30 rabbits. After 6 weeks (group A), 3 months (group B) and 6 months (group C) in vivo evaluation of the twitch-tension and fatigue index were done. Next the scapulas with muscles were examined by CT. During the first 6 weeks a marked reduction in power and fatigue index by about 20% and 10-15%, respectively, in comparison with the control side was noted. These findings remained unchanged at 3 and 6 months. The CT examination showed fatty muscle degeneration, mainly in the 1/3 distal part of supraspinatus, but not in the infraspinatus muscle.

RANTES and Chemotactic Activity in Synovial Fluids From Patients With Rheumatoid Arthritis and Osteoarthritis

A massive accumulation of inflammatory cells in synovial tissues is a major pathological feature of rheumatoid arthritis (RA). Neutrophiles dominate synovial fluid while rheumatoid synovium is infiltrated with mononuclear cells. Mechanisms regulating influx of particular subpopulations of leukocytes into articular cavity and synovium compartment are not completely defined. An increasing amount of data supports a crucial role of a C-C chemokine RANTES in the RA pathogenesis. Our objective is to evaluate chemotactic activity for neutrophils (NCA), lymphocytes (LCA), and monocytes (MoCA) in SFs obtained from patients with RA and osteoarthritis (OA). We also aimed to characterise the relation between chemotactic activity, RANTES, and percentage distribution of leukocytes in SF. SFs from 11 patients with RA and 6 with OA were included in the study. Modified microchamber Boyden method was employed to assess chemotactic activity. Cytological and biochemical analysis of SF was performed. RANTES was measured with ELISA. Rheumatoid SFs were rich in cells with predominance of neutrophiles while osteoarthritic fluids were lymphocytic. RA SFs were also characterised by increased lactoferrin level. Both NCA and LCA were higher in SF from patients with RA (62 ± 12 and 24 ± 6 cells/HPF, resp) as compared to patients with OA (23 ± 6; P < .05 and 6 ± 2 cells/HPF; P < 0.05). The chemoattractive effect of RA SF was more pronounced on neutrophiles than on lymphocytes. RA SF expressed high RANTES levels (145 ± 36 pg/mL), while OA SF was characterised by only trace amount of this chemokine (2 ± 1 pg/mL). We found positive correlation of RANTES with chemotactic activity for mononuclear cells (LCA+MoCA; R = 0.61; P < .05). Surprisingly, RANTES correlated also positively with neutrophiles number (R = 0.77; P < 0.001). Rheumatoid SF possesses strong chemotactic potency for leukocytes. RANTES is overexpressed in RA SF and is a potential mediator influencing intensity and composition of cellular infiltration in joints affected with inflammatory arthritis.

Avascular necrosis after surgical treatment for developmental dysplasia of the hip

We reviewed the medical records of 101 patients with developmental dysplasia of the hip who were treated with Dega’s (102 hips), or Salter’s (42 hips) osteotomy preceded by open reduction and femoral intertrochanteric osteotomy. The minimal follow-up was 17 years. At the last follow-up, there were proximal femoral growth disturbances in 52 hips (36%). In 20 hips, the disturbances were graded as mild and in six as severe. We found significantly better clinical and radiological results in hips without avascular changes. Risk factors for the development of avascular necrosis were: involvement of the left side and surgical treatment initiated after 2 years of age without pre-operative traction and without femoral shaft shortening. We found that the incidence of avascular necrosis increased with the length of follow-up. The avascular necrosis influenced both clinical and radiological results.RésuméNous avons examiné les registres médicaux de 101 malades avec une dysplasie congénitale de la hanche qui ont été traitée par ostéotomie de Dega (102 hanches) ou Salter (42 hanches) précédé par réduction ouverte et ostéotomie fémorale intertrochantérienne. Le suivi minimal était de 17 ans. Àu dernier recul il y avait des troubles de croissance des fémurs proximaux dans 52 hanches (36%). Dans 20 hanches les troubles ont été notés comme discrets et en six comme sévères. Nous avons trouvé des résultats cliniques et radiologiques bien meilleurs dans les hanches sans troubles vasculaires. Les facteurs du risque pour le développement d’une nécrose avasculaire étaient: l’affection du côté gauche, le traitement chirurgical commencé après l’âge de 2 ans sans traction préopératoire et sans raccourcissement de la diaphyse fémorale. Nous avons trouvé que la fréquence des nécroses avasculaires a augmenté avec la durée d’observation. La nécrose avasculaire a influencé les résultats cliniques et radiologiques.

An Isolated Medial Patellofemoral Ligament Reconstruction with Patellar Tendon Autograft

The aim of the study was to evaluate the results of the medial patellofemoral ligament reconstruction with a medial strip of patellar tendon autograft after a minimum 2-year followup. Ten patients (10 knees) were operated on by one surgeon, according to the modified technique, described by Camanho, without any bone plug at free graft end. The mean age of the patients was 27.2 years (ranging from 18 to 42 years). The mean follow-up period was 3 years and 7 months. All patients were reviewed prospectively. At the last follow-up visit, all the patients demonstrated a significant improvement in terms of patellofemoral joint stability, all aspects of the KOOS questionnaire, and Kujala et al.s score (59.7 points preoperatively and 84.4 points at the last followup). No patient revealed recurrent dislocation. The SF-36 score revealed a significant improvement in bodily pain, general health, physical role functioning, social role functioning, and physical functioning domains. The described MPFL reconstruction with the use of the medial 1/3rd of patella tendon is an effective procedure that gives satisfactorily patellofemoral joint functions, improves the quality of life, and provides much pain relief. It is relatively simple, surgically not extensive, and economically cost-effective procedure.

Leg length discrepancy in Legg-Calve-Perthes disease.

The purpose of this study was to determine the incidence of the leg length discrepancy (LLD) in Legg-Calve-Perthes disease and whether there is any correlation between LLD and age at onset, gender, type of treatment, and severity of disease. The study population consisted of 261 patients with unilateral involvement who had reached skeletal maturity at last follow-up. All hips were treated by containment methods (bed rest and traction in abduction, Petri cast, brace, varus osteotomy, Salter osteotomy, and shelf acetabuloplasty). The late results were classified according to the Stulberg classification. LLD was found in 33 patients and ranged from 1 to 5.2 cm (average 2.51 cm). The limb shortening was observed in Herring group B (average 2.18 cm) and C (average 2.82 cm) and was statistically significant more common in group C. The statistical analysis revealed no statistical difference between the age at onset, sex, and type of treatment with regard to LLD; nevertheless, patients in Herring group C with LLD were younger than patients in group B, and LLD was seen more often after varus osteotomy. The amount of residual shortening of the affected limb in Legg-Calve-Perthes disease at the end of skeletal growth seems to depend on the extent of involvement and the presence of a growth arrest. A varus osteotomy produces more significant shortening than other methods of treatments. The age at the onset of symptoms and sex do not influence the amount of LLD, but early onset of the disease can result in more severe limb shortening.

Transient synovitis of the hip: a comprehensive review.

Transient synovitis is a benign, self-limiting condition that is diagnosed after the exclusion of more serious causes of acute hip pain in children. Although its etiology remains unclear, it is largely believed to be viral in nature. Transient synovitis typically presents as an acute onset of thigh pain with a limp or an unwillingness to bear weight. It can be distinguished from similar conditions by the absence of fever, as well as unremarkable bloodwork (WBC, CRP, ESR), radiographs, and hip aspiration. Conservative treatment and observation are the mainstay of management. Resolution of symptoms generally occurs by 1 week and may be accelerated by NSAIDs. Although numerous papers have emerged over the years with an effort to advance our understanding, many questions remain about its pathomechanics, etiology, and how to exclude other more serious conditions that present similarly.

Secondary gleno-humeral joint dysplasia in children with persistent obstetric brachial plexus palsy

The study aimed to evaluate the degree of gleno-humeral joint deformation in children with persistent obstetric brachial plexus palsy and its effect on limb function. Computer tomography was performed in 24 children in the mean age of 6.1 years. There were eight boys and 16 girls. Gleno-scapular angle, congruency of gleno-humeral joint and joint deformity according to Waters at all. criteria were measured. The mean functional score according to the Mallet classification system was 12.3 points. The joint was stabile in nine, subluxed in seven and dislocated in nine cases. Gleno-scapular angle in affected joints was 23.3° and in non-affected 4.5°. The glenoid was statistically more retroverted in older children. With more severe posterior incongruence there was statistically greater limitation of passive external rotation, active internal rotation and a poorer functional result according to Mallet. Abnormalities were found also in the humeral head, being deformed and smaller compared to the non-affected side in all cases. Glenoid retroversion, posterior subluxation/dislocation of humeral head and smaller humeral head size are the abnormalities, most often identified in CT examinations. Shoulder function and in particular, passive, external rotation are closely associated with the degree of deformity of the glenoid, as well as with the extent of posterior humeral head dislocation.

Periprosthetic bone remodeling around short stem.

Total hip arthroplasty (THA) has become standard treatment for advanced degenerative changes of the hip. A few studies have reported promising clinical outcomes with the Metha stem fixated by metaphyseal anchoring. This study evaluated early bone remodeling around the Metha stem during 12 months of follow-up. The study population included 36 patients (18 women and 18 men) with a mean age of 50.4 years who underwent THA between 2009 and 2011 for advanced degenerative changes of the hip with the Metha stem. Patients were evaluated on the day of surgery, 10 days postoperatively, and then at 3, 6, and 12 months postoperatively. Evaluation included Harris Hip Score and dual-energy x-ray absorptiometry (DEXA) scanning in 7 Gruen zones. At 12 months postoperatively, Harris Hip Score increased significantly by 38 points. A significant change in bone mineral density (BMD) was found immediately after surgery; this change was most pronounced in Gruen zone 3 (+36%), followed by Gruen zones 2 and 5. The smallest postoperative BMD increase was observed in Gruen zone 7 (+3.66%). In contrast, at 3 months postoperatively, a trend toward decreased BMD was observed in all Gruen zones. At 6 months postoperatively, mean BMD decreased in all Gruen zones except for Gruen zone 6. At 12 months postoperatively, mean BMD increased in Gruen zones 2 through 6, with the highest value (30%) observed in Gruen zone 3; in Gruen zones 1 and 2, mean BMD decreased. Short-term assessment of periprosthetic bone remodeling after uncemented Metha stem implantation revealed different host-bone responses. Apparently, the Metha stem can reduce BMD loss in the proximal femur. DEXA is a precise method for assessing BMD changes around implanted Metha stem.

[Osteoarthritis: etiology, risk factors, molecular mechanisms].

Osteoarthritis is an incurable joint disease manifesting itself with gradually progressing degenerative changes, leading to premature motor disability. These changes mainly occur owing to an imbalance between the processes of degeneration and regeneration of articular cartilage structures. Until now many risk factors favoring the development of degenerative joint disease have been identified. These include age, weight, previously sustained traumas to joints, sports, sex and genetic predisposition. The latest scientific reports confirm that the pathogenesis of changes in osteoarthritic joints is complex and occurs on many levels. Enzymes belonging to the metalloproteinases family are mainly responsible for the degeneration of articular cartilage. Their activity is regulated by numerous pro-inflammatory cytokines, transcription factors and miRNA. A thorough analysis of all processes occurring in the afflicted joints needs to be carried out before effective therapeutic strategies can be developed.