Margaret E. Browne | Researchain

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Featured researches published by Margaret E. Browne.

Tetrahedron Letters | 1995

Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

Margaret E. Browne; Duane A. Burnett; Mary Ann Caplen; Lian-Yong Chen; John W. Clader; Martin S. Domalski; Sundeep Dugar; Pradeep Pushpavanam; Rosy Sher; Wayne Vaccaro; Monica Viziano; Hongrong Zhao

Abstract New conditions for the acid chloride-imine reaction of nonactivated alkyl acid chlorides provide 3-alkyl substituted β-lactams in good yields with high trans selectivity.

Bioorganic & Medicinal Chemistry Letters | 2002

Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

Duane A. Burnett; Mary Ann Caplen; Margaret E. Browne; Hongrong Zhau; Scott W. Altmann; Harry R. Davis; John W. Clader

Fluorescent analogues of the cholesterol absorption inhibitor (CAI), Sch 58235, have been designed and synthesized as single enantiomers. Biological testing reveals that they are potent CAIs and are suitable tools for the investigation of the azetidinone CAI mechanism of action (MOA).

Journal of Medicinal Chemistry | 1996

2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

John W. Clader; Duane A. Burnett; Mary Ann Caplen; Martin Domalski; Sundeep Dugar; Wayne Vaccaro; Rosy Sher; Margaret E. Browne; Hongrong Zhao; Robert E. Burrier; Brian G. Salisbury; Harry R. Davis

Archive | 1994

Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents

Sundeep Dugar; John W. Clader; Duane A. Burnett; Margaret E. Browne; Harry R. Davis

e-EROS Encyclopedia of Reagents for Organic Synthesis | 2001

4‐(Chloromethyl)‐3,5‐dimethylisoxazole

Margaret E. Browne; Duane A. Burnett

Archive | 2000

PIPERIDINE AND PIPERAZINE DERIVATIVES AS MUSCARINIC ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE

Theodros Asberom; Allen Barnett; Joel G. Berger; Craig D. Boyle; Margaret E. Browne; Samuel Chackalamannil; Wei K. Chang; Lian-Yong Chen; John W. Clader; Sundeep Dugar; Michael J. Green; Hubert Josien; Joseph A. Kozlowski; Derek B. Lowe; Stuart W. McCombie; Robert D. McQuade; Margaret H. Sherlock; Jayaram R. Tagat; Wing C. Tom; Wayne Vaccaro; Susan F. Vice; Yuguang Wang

Archive | 1997

Piperazines benzylpiperidine and muscarinic antagonists

Derek B. Lowe; Wei Chang; Joseph A. Kozlowski; Joel G. Berger; Robert D. McQuade; Allen Barnett; Margaret H. Sherlock; Wing C. Tom; Sundeep Dugar; Lian-Yong Chen; John W. Clader; Samuel Chackalamannil; Yuguang Wang; Stuart W. McCombie; Jayaram R. Tagat; Susan F. Vice; Wayne Vaccaro; Michael J. Green; Margaret E. Browne; Theodros Asberom

Archive | 1997

Piperidine and piperazine derivatives and their use as muscarinic antagonists

Derek B. Lowe; Wei K. Chang; Joseph A. Kozlowski; Joel G. Berger; Robert D. McQuade; Allen Barnett; Margaret H. Sherlock; Wing C. Tom; Sundeep Dugar; Lian-Yong Chen; John W. Clader; Samuel Chackalamannil; Yuguang Wang; Stuart W. McCombie; Jayaram R. Tagat; Susan F. Vice; Wayne Vaccaro; Michael J. Green; Margaret E. Browne; Theodros Asberom; Craig D. Boyle; Hubert Josien

Archive | 1996

Bencilpiperidinas y piperazinas como antagonistas muscarinicos.

Theodros Asberom; Allen Barnett; Joel G. Berger; Margaret E. Browne; Samuel Chackalamannil; Wei Chang; Lian-Yong Chen; John W. Clader; Sundeep Dugar; Michael J. Green; Joseph A. Kozlowski; Derek B. Lowe; Stuart W. McCombie; Robert D. McQuade; Margaret Scherlock; Jayaram R. Tagat; Wing C. Tom; Wayne Vaccaro; Susan F. Vice; Yuguang Wang

Archive | 1996