Margaret M. Wheeler

SYNTHESIS OF A RING A PRECURSOR OF DOXORUBICIN : STEREOSELECTIVE CONTROL OF THE EPOXIDATION OF A HOMOALLYLIC ALCOHOL BY HYDROXYL AND ESTER GROUPS

Abstract The key step in a synthesis of a precursor for ring A in doxorubicin is the stereoselective control of the epoxidation of a homoallylic alcohol by ester and hydroxyl groups; the result leads to a new method of forming lactones in excellent yields under neutral conditions.