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Dive into the research topics where Margot Acosta is active.

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Featured researches published by Margot Acosta.


FEBS Letters | 1974

Probing the molecular basis of antidiuretic specificity and duration of action with synthetic peptides

M. Manning; L. Balaspiri; J. Judd; Margot Acosta; Wilbur H. Sawyer

The individual structural alterations of AVP which bring about enhancement of A/V specificity are: (a) deamination of position one [3] ; (b) enhancement of lipophilicity at position 4 [ 1,8] and (c) substitution of Dfor L-arginine at position 8 [ 51. When all three changes were incorporated into one molecule the resulting peptide [ 1 deamino-4valine] 8-D-arginine vasopressin (dVDAVP) was found to be the most highly specific antidiuretic peptide ever reported [lo] . dVDAVP has undetectable vasopressor activity, antidiuretic activity about four times that of AVP and an A/V ratio of over 123 000 compared to 0.9 for AVP. It also exhibits a markedly prolonged duration of action similar to that previously observed for [ 1 -deamino] -8-D7arginine vasopressin (DDAVP) [7] . The present communiation summarizes our subsequent separately reported findings on the relative effects of these structural changes in contributing to (1) enhanced antidiuretic specificity [ 1 I] and (2)


Endocrinology | 1974

Structural Changes in the Arginine Vasopressin Molecule that Enhance Antidiuretic Activity and Specificity1

Wilbur H. Sawyer; Margot Acosta; L. Balaspiri; J. Judd; M. Manning


Endocrinology | 1974

Structural Changes in the Arginine Vasopressin Molecule that Prolong Its Antidiuretic Action

Wilbur H. Sawyer; Margot Acosta; Maurice Manning


Endocrinology | 1974

Neurohypophysial Peptides in the Bovine Hypothalamus:The Relationship of Neurophysin I to Oxytocin, and Neurophysin II to Vasopressin in Supraoptic and Paraventrieular Regions

Earl A. Zimmerman; Alan G. Robinson; M. Kazim Husain; Margot Acosta; Andrew G. Frantz; Wilbur H. Sawyer


Journal of Medicinal Chemistry | 1973

Solid phase synthesis of (1-deamino,4-valine)-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects.

Maurice Manning; L. Balaspiri; Margot Acosta; Wilbur H. Sawyer


Journal of Medicinal Chemistry | 1973

Solid-phase synthesis and some pharmacological properties of 4-threonine analogs of vasopressins and vasotocin and of arginine-vasopressin and arginine-vasotocin.

Maurice Manning; Esther J. Coy; Wilbur H. Sawyer; Margot Acosta


Journal of Medicinal Chemistry | 1973

Solid-phase synthesis and some pharmacological properties of deamino-4-threonine analogs of the vasopressins and vasotocin and [deamino]arginine-vasotocin

Maurice Manning; Esther J. Coy; Margot Acosta; Wilbur H. Sawyer


ChemInform | 1973

SOLID-PHASE SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 4-THREONINE ANALOGS OF VASOPRESSINS AND VASOTOCIN AND OF ARGININE-VASOPRESSIN AND ARGININE-VASOTOCIN

Maurice Manning; E. J. Coy; Wilbur H. Sawyer; Margot Acosta


Journal of Medicinal Chemistry | 1974

Synthesis and some pharmacological properties of 8-L-homoarginine-vasopressin and of 1-deamino-8-L-homoarginine-vasopressin.

Gunnar Lindeberg; Miklos Bodanszky; Margot Acosta; Wilbur H. Sawyer


ChemInform | 1974

SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 8‐L‐HOMOARGININE‐VASOPRESSIN AND OF 1‐DEAMINO‐8‐L‐HOMOARGININE‐VASOPRESSIN

Gunnar Lindeberg; Miklos Bodanszky; Margot Acosta; Wilbur H. Sawyer

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Miklos Bodanszky

Case Western Reserve University

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