Margot Acosta
Columbia University
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Featured researches published by Margot Acosta.
FEBS Letters | 1974
M. Manning; L. Balaspiri; J. Judd; Margot Acosta; Wilbur H. Sawyer
The individual structural alterations of AVP which bring about enhancement of A/V specificity are: (a) deamination of position one [3] ; (b) enhancement of lipophilicity at position 4 [ 1,8] and (c) substitution of Dfor L-arginine at position 8 [ 51. When all three changes were incorporated into one molecule the resulting peptide [ 1 deamino-4valine] 8-D-arginine vasopressin (dVDAVP) was found to be the most highly specific antidiuretic peptide ever reported [lo] . dVDAVP has undetectable vasopressor activity, antidiuretic activity about four times that of AVP and an A/V ratio of over 123 000 compared to 0.9 for AVP. It also exhibits a markedly prolonged duration of action similar to that previously observed for [ 1 -deamino] -8-D7arginine vasopressin (DDAVP) [7] . The present communiation summarizes our subsequent separately reported findings on the relative effects of these structural changes in contributing to (1) enhanced antidiuretic specificity [ 1 I] and (2)
Endocrinology | 1974
Wilbur H. Sawyer; Margot Acosta; L. Balaspiri; J. Judd; M. Manning
Endocrinology | 1974
Wilbur H. Sawyer; Margot Acosta; Maurice Manning
Endocrinology | 1974
Earl A. Zimmerman; Alan G. Robinson; M. Kazim Husain; Margot Acosta; Andrew G. Frantz; Wilbur H. Sawyer
Journal of Medicinal Chemistry | 1973
Maurice Manning; L. Balaspiri; Margot Acosta; Wilbur H. Sawyer
Journal of Medicinal Chemistry | 1973
Maurice Manning; Esther J. Coy; Wilbur H. Sawyer; Margot Acosta
Journal of Medicinal Chemistry | 1973
Maurice Manning; Esther J. Coy; Margot Acosta; Wilbur H. Sawyer
ChemInform | 1973
Maurice Manning; E. J. Coy; Wilbur H. Sawyer; Margot Acosta
Journal of Medicinal Chemistry | 1974
Gunnar Lindeberg; Miklos Bodanszky; Margot Acosta; Wilbur H. Sawyer
ChemInform | 1974
Gunnar Lindeberg; Miklos Bodanszky; Margot Acosta; Wilbur H. Sawyer