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Featured researches published by Mari Endo.


Journal of Gastroenterology | 2014

Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors

Mari Endo; Masatoshi Hori; Hiroshi Ozaki; Tetsuro Oikawa; Toshihiko Hanawa

BackgroundDaikenchuto (DKT), a gastrointestinal prokinetic Japanese herbal medicine, is prescribed for patients with postoperative ileus (POI) and adhesive bowel obstruction following abdominal surgery. Several mechanisms for the amelioration of POI by DKT have been suggested; however, it has remained unclear whether DKT shows anti-inflammatory effects in POI. In the present study, we investigated the effects of DKT in a mouse POI model and attempted to clarify the detailed mechanisms of action.MethodIntestinal manipulation (IM) was applied to the distal ileum of mice. DKT was administered orally to the animals 4 times before and after IM. Gastrointestinal transit in vivo, leukocyte infiltration, cytokine mRNA expression and gastrointestinal motility were analyzed. We also investigated the effects of the α7nAChR antagonist methyllycaconitine citrate (MLA) on the DKT-mediated ameliorative action against POI, and we studied the effects of DKT on inflammatory activity in α7nAChR knockout mice.ResultsDKT treatment led to recovery of the delayed intestinal transit induced by IM. DKT significantly inhibited the infiltration of neutrophils and CD68-positive macrophages, and inhibited mRNA expressions of TNF-α and MCP-1. MLA significantly reduced the anti-inflammatory action of DKT, and the amelioration of macrophage infiltration by DKT was partially suppressed in α7nAChR knockout mice.ConclusionsIn conclusion, in addition to the gastrointestinal prokinetic action, DKT serves as a novel therapeutic agent for POI characterized by its anti-inflammatory potency. The DKT-induced anti-inflammatory activity may be partly mediated by activation of α7nAChR.


Neurogastroenterology and Motility | 2017

Zingiberis Siccatum Rhizoma, the active component of the Kampo formula Daikenchuto, induces anti-inflammatory actions through α7 nicotinic acetylcholine receptor activation

Mari Endo; Masaru Hori; Taiki Mihara; Hiroshi Ozaki; Tetsuro Oikawa; Hiroshi Odaguchi; Toshihiko Hanawa

We previously reported that Daikenchuto (DKT), a gastrointestinal prokinetic Japanese herbal (Kampo) medicine used for the treatment of postoperative ileus (POI), has characteristic potent anti‐inflammatory activity. This effect may be partly mediated by the activation of α7 nicotinic acetylcholine receptor (nAChR). In this study, we identified the specific herbs in DKT that induce anti‐inflammatory action.


Journal of Pharmacological Sciences | 2018

Possible anti-inflammatory role of Zingiberis processum rhizoma, one component of the Kampo formula daikenchuto, against neutrophil infiltration through muscarinic acetylcholine receptor activation

Mari Endo; Masatoshi Hori; Hiroshi Ozaki; Tetsuro Oikawa; Hiroshi Odaguchi; Toshihiko Hanawa

Zingiberis processum rhizoma (ZPR) is a major active component of daikenchuto (DKT), which induces anti-inflammatory action by inhibiting macrophage infiltration. However, it is unclear whether ZPR is related to DKT-induced anti-inflammatory action via a reduction of neutrophil infiltration against postoperative ileus (POI). In this study, we orally administered individual herbal components of DKT to mice four times before and after intestinal manipulation (IM). The anti-inflammatory action of each crude drug was evaluated by histochemical analysis of relevant molecules. The results showed that treatment with all herbal components of DKT significantly inhibits neutrophil infiltration. This inhibition of neutrophil infiltration by ZPR was significantly reduced in 5-hydroxytryptamine receptor 4 (5-HT4R) knockout (KO) mice but not in alpha-7 nicotinic acetylcholine receptor (α7nAChR) KO mice. Also, transient receptor potential ankyrin 1 (TRPA1) and muscarinic acetylcholine receptor (mAChR) antagonists partly and significantly inhibited the amelioration of neutrophil infiltration by ZPR. Therefore, DKT-induced anti-inflammatory action, mediated by inhibition of neutrophil infiltration in POI, depends, in part, on the effects of ZPR. ZPR activates TRPA1 channels, possibly in enterochromaffin (EC) cells, to release 5-HT. This 5-HT stimulates 5-HT4R in the myenteric plexus neurons to release acetylcholine, which, in turn, activates mAChR to inhibit inflammation in POI.


Traditional & Kampo Medicine | 2017

13C-butyrate breath test is a novel non-invasive screening tool for anti-inflammatory activity of kampo medicines

Mari Endo; Tetsuro Oikawa; Takayuki Hoshino; Tsutomu Hatori; Tsukasa Matsumoto; Hiroshi Odaguchi; Toshihiko Hanawa

13C‐butyrate breath test is a non‐invasive method for detecting inflammation in experimental colitis. We investigated whether this test could assess the anti‐inflammatory effect of kampo medicines in dextran sulfate sodium salt (DSS)‐murine colitis.


Journal of Pharmacological Sciences | 2014

Rikkunshito, a Kampo Medicine, Ameliorates Post-operative Ileus by Anti-inflammatory Action

Mari Endo; Masatoshi Hori; Hiroshi Ozaki; Tetsuro Oikawa; Toshihiko Hanawa


Journal of Traditional Medicines | 2007

Pharmacological analysis for the optimal combination ratio of Shakuyaku and Kanzo in Shakuyakukanzoto

Mari Endo; Tetsuro Oikawa; Shinyu Nunome; Haruki Yamada; Toshihiko Hanawa


Journal of Traditional Medicines | 2009

Suppression of murine colitis by Kampo medicines, with special reference to the efficacy of saireito

Mari Endo; Tetsuro Oikawa; Takayuki Hoshino; Tsutomu Hatori; Tsukasa Matsumoto; Toshihiko Hanawa


Journal of Smooth Muscle Research | 2008

The utility of noninvasive 13C-acetate breath test using a new solid test meal to measure gastric emptying in mice

Takayuki Hoshino; Tetsuro Oikawa; Mari Endo; Toshihiko Hanawa


Journal of Pharmacological Sciences | 2013

The 13C-Butyrate Breath Test: a New Non-Invasive Method for Assessing Colitis in a Murine Model

Mari Endo; Tetsuro Oikawa; Takayuki Hoshino; Tsutomu Hatori; Tsukasa Matsumoto; Toshihiko Hanawa


Inflammation | 2017

Therapeutic Action of Honokiol on Postoperative Ileus via Downregulation of iNOS Gene Expression

Taiki Mihara; Shoma Mikawa; Noriyuki Kaji; Mari Endo; Tetsuro Oikawa; Jan Tong-Rong; Hiroshi Ozaki; Masatoshi Hori

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