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Dive into the research topics where Mari Markkanen-Leppänen is active.

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Featured researches published by Mari Markkanen-Leppänen.


Acta Oto-laryngologica | 1997

Microvascular Free Flaps in Head and Neck Cancer Surgery in Finland 1986–1995

Antti Mäkitie; Kalle Aitasalo; J. Pukander; J. Virtaniemi; K. Hyrynkangas; E. Suominen; J. Vuola; Risto Kontio; Mari Markkanen-Leppänen; Hannu Lehtonen; S. Asko-Seljavaara; Reidar Grénman

Microvascular free tissue transfer has in many cases replaced classic flap techniques and is now an established workhorse for head and neck reconstructions. In this retrospective study the over 300 patients, who had microvascular free flap reconstructions in head and neck cancer surgery in Finland during a 10-year period (1986-1995) were reviewed. The operations were performed in the University Hospitals by plastic surgeons, ENT specialists or maxillofacial surgeons. The cases consisted of defects resulting from resection of oral cavity tumors (63%), mid- or upper-face and skullbase tumors (20%) and hypopharyngo-esophageal tumors (17%). The series includes a wide range of flap types and analyses flap outcome and complications. A total of 313 cases was reconstructed by 317 flaps (forearm flaps 47%, latissimus dorsi flaps 19%, free jejunum or colon transfers 15%, free iliaca crest flaps 8% and other flaps 11%). Thrombosis of one of the vessels and haematoma were the most frequent causes of failure in microvascular free tissue transfer. A total flap necrosis occurred in 27 (8.5%) and a partial necrosis in 12 (4%) patients. The most reliable flap in terms of survival was the radial forearm flap. The ever-improving success of microvascular free tissue transfer has made it a useful procedure for head and neck reconstructions. There is also a growing need for microvascular team surgery in the field of head and neck cancer therapy.


Clinical Medicine Insights: Pathology | 2010

Bilateral Basal Cell Adenocarcinoma of the Parotid Gland: In a Recipient of Kidney Transplant

Mari Markkanen-Leppänen; Antti Mäkitie; Fabricio Passador-Santos; Ilmo Leivo; Jaana Hagström

We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy. BcAC is a salivary gland malignancy first recognized as a distinct neoplastic entity in WHO classification of salivary gland tumours in 1991. Over 90% of BcACs are detected in the parotid gland. The most important differential diagnosis is basal cell adenoma. Infiltrative growth is the distinguishing feature of BcAC. Administration of immunosuppressive medication to this patient for three decades may have contributed to development of this rare neoplasia. To our knowledge, similar cases of BcAC have not been reported previously.


Frontiers in Oncology | 2018

Transoral Robotic Surgery in the Nordic Countries: Current Status and Perspectives

Antti Mäkitie; Harri Keski-Säntti; Mari Markkanen-Leppänen; Leif Bäck; Petri Koivunen; Tomas Ekberg; Karl Sandström; Göran Laurell; Mathias von Beckerath; Johan S Nilsson; Peter Wahlberg; Lennart Greiff; Lena Norberg Spaak; Thomas Kjærgaard; Christian Godballe; Oddveig Rikardsen; Hani Ibrahim Channir; Niclas Rubek; Christian von Buchwald

Background: The five Nordic countries with a population of 27 M people form a rather homogenous region in terms of health care. The management of head and neck cancer is centralized to the 21 university hospitals in these countries. Our aim was to gain an overview of the volume and role of transoral robotic surgery (TORS) and to evaluate the need to centralize it in this area as the field is rapidly developing. Materials and Methods: A structured questionnaire was sent to all 10 Departments of Otorhinolaryngology—Head and Neck Surgery in the Nordic countries having an active programme for TORS in December 2017. Results: The total cumulative number of performed robotic surgeries at these 10 Nordic centers was 528 and varied between 5 and 240 per center. The median annual number of robotic surgeries was 38 (range, 5–60). The observed number of annually operated cases remained fairly low (<25) at most of the centers. Conclusions: The present results showing a limited volume of performed surgeries call for considerations to further centralize TORS in the Nordic countries.


Laryngoscope | 2016

Dysphagia and malignancy: A three-year follow-up and survey of National Cancer Registry data.

Pia Nevalainen; Ahmed Geneid; Taru Ilmarinen; Petra Pietarinen; Teemu J. Kinnari; Heikki Rihkanen; Johanna Ruohoalho; Mari Markkanen-Leppänen; Leif Bäck; Perttu Arkkila; Leena-Maija Aaltonen

Dysphagia may cause concern about malignancy. Symptoms are often unspecific; thus, it is essential to identify those requiring further investigations.


Otolaryngology-Head and Neck Surgery | 2015

Developing a Registry for Complications in Otorhinolaryngologic Surgery Tonsil Surgery as a Pilot Cohort

Johanna Ruohoalho; Antti Mäkitie; Timo Atula; Annika Takala; Harri Keski-Säntti; Katri Aro; Aaro Haapaniemi; Mari Markkanen-Leppänen; Leif Bäck

Objective To find a suitable method to prospectively register all tonsil surgery–related complications. Study Design Prospective cohort study. Setting Tertiary care center. Subjects and Methods From September 2011 to February 2012, patients undergoing tonsillectomy or tonsillotomy were enrolled. A wide range of demographic and clinical data including incidents of postoperative complications was recorded prospectively, and patient records were reviewed 9 months after the end of study period. We evaluated the coverage of prospective data recording, analyzed the complication rates, and assessed the process of registration. Results A total of 573 patients were recruited. The study registry including 57 variables required the completion of missing data before analysis. Of all 79 patients with a complication, 69.6% were captured prospectively at the emergency department, and the rest were found when reviewing the patient records. The proportion of prospectively captured complications was highest for the most common complications (eg, 81.1% for secondary hemorrhage). The overall complication rate was 13.8%. Secondary hemorrhage was the most common complication, with the incidence of 9.6%. Conclusion We have demonstrated the initial feasibility of a prospective complication registry for otorhinolaryngology procedures, and the results can be applied accordingly. We also present 5 practical recommendations when initiating a functional registry. Particular attention should be paid to recognition and registration of both rare and serious events. Regular analysis of the results is required in order to respond to possible changes in the incidence or nature of complications.


Oncology Reports | 2006

Cyclooxygenase-2 expression in squamous cell carcinoma of the oral cavity and pharynx: Association to p53 and clinical outcome

Timo Atula; Johan Hedström; Ari Ristimäki; Patrik Finne; Ilmo Leivo; Mari Markkanen-Leppänen; Caj Haglund


Anticancer Research | 2003

Tenascin-C expression and its prognostic significance in oral and pharyngeal squamous cell carcinoma

Timo Atula; Johan Hedström; Patrik Finne; Ilmo Leivo; Mari Markkanen-Leppänen; Caj Haglund


European Archives of Oto-rhino-laryngology | 2017

Work-up of globus: assessing the benefits of neck ultrasound and videofluorography.

Pia Järvenpää; Taru Ilmarinen; Ahmed Geneid; Petra Pietarinen; Teemu J. Kinnari; Heikki Rihkanen; Johanna Ruohoalho; Mari Markkanen-Leppänen; Leif Bäck; Perttu Arkkila; Leena-Maija Aaltonen


Acta Oto-laryngologica | 2014

Percutaneous endoscopic gastrostomy tube placement by otorhinolaryngologist-head and neck surgeons

Leif Bäck; Alexander Benders; Petra Pietarinen; Harri Keski-Säntti; Mari Markkanen-Leppänen; Marianne Udd; Jorma Halttunen; Antti Mäkitie; Leena Kylänpää


European Archives of Oto-rhino-laryngology | 2018

Olfactory and gustatory functions after free flap reconstruction and radiotherapy for oral and pharyngeal cancer: a prospective follow-up study

Markus Lilja; Mari Markkanen-Leppänen; Sanna Viitasalo; Kauko Saarilahti; Andrew Lindford; Patrik Lassus; Antti Mäkitie

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Leif Bäck

University of Helsinki

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Harri Keski-Säntti

Helsinki University Central Hospital

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Timo Atula

University of Helsinki

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Caj Haglund

University of Helsinki

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