Maria Arduini
University of Padua
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Publication
Featured researches published by Maria Arduini.
Chemical Communications | 2003
Maria Arduini; Fulvia Felluga; Fabrizio Mancin; Paola Rossi; Paolo Tecilla; Umberto Tonellato; Nicola Valentinuzzi
A selective Al3+ fluorescence chemosensor able to detect concentrations of metal ion in the nanomolar range has been realized. The remarkable sensitivity is the result of the FRET amplification of the fluorescence emission of the ligand subunit.
Nanotechnology | 2009
Chiara Compagnin; Luca Baù; Maddalena Mognato; Lucia Celotti; Giovanni Miotto; Maria Arduini; Francesca Moret; Caterina Fede; Francesco Selvestrel; Iria Maria Rio Echevarria; Fabrizio Mancin; Elena Reddi
Nanosized objects made of various materials are gaining increasing attention as promising vehicles for the delivery of therapeutic and diagnostic agents for cancer. Photodynamic therapy (PDT) appears to offer a very attractive opportunity to implement drug delivery systems since no release of the sensitizer is needed to obtain the therapeutic effect and the design of the nanovehicle should be much easier. The aim of our study was to investigate the use of organic-modified silica nanoparticles (NPs) for the delivery of the second-generation photosensitizer meta-tetra(hydroxyphenyl)chlorin (mTHPC) to cancer cells in vitro. mTHPC was entrapped in NPs (approximately 33 nm diameter) in a monomeric form which produced singlet oxygen with a high efficiency. In aqueous media with high salt concentrations, the NPs underwent aggregation and precipitation but their stability could be preserved in the presence of foetal bovine serum. The cellular uptake, localization and phototoxic activity of mTHPC was determined comparatively in human oesophageal cancer cells after its delivery by the NPs and the standard solvent ethanol/poly(ethylene glycol) 400/water (20:30:50, by vol). The NP formulation reduced the cellular uptake of mTHPC by about 50% in comparison to standard solvent while it did not affect the concentration-dependent photokilling activity of mTHPC and its intracellular localization. Fluorescence resonance energy transfer measurements, using NPs with mTHPC physically entrapped and a cyanine covalently linked, and ultracentrifugation experiments indicated that mTHPC is transferred from NPs to serum proteins when present in the medium. However, the coating of the NP surface with poly(ethylene glycol) largely prevented the transfer to proteins. In conclusion, mTHPC is rapidly transferred from the uncoated nanoparticles to the serum proteins and then internalized by the cells as a protein complex, irrespective of its modality of delivery.
Chemical Communications | 2009
Luca Baù; Barbora Bártová; Maria Arduini; Fabrizio Mancin
A surfactant-free synthesis of mesoporous and hollow silica nanoparticles is reported in which boron acts as the templating agent. Using such a simple and mild procedure as a treatment with water, the boron-rich phase is selectively removed, affording mesoporous pure silica nanoparticles with wormhole-like pores or, depending on the synthetic conditions, silica nanoshells.
Organic Letters | 2012
Luca Baù; Francesco Selvestrel; Maria Arduini; Ilaria Zamparo; Claudia Lodovichi; Fabrizio Mancin
NanoChlor, a nanoparticle-based fluorescent probe for chloride that is both ratiometric and capable of spontaneously penetrating neuronal cells at submillimolar concentrations, was designed and studied. NanoChlor is built on silica nanoparticles grafted with 6-methoxyquinolinium as the chloride-sensitive component and fluorescein as the reference dye. A Stern-Volmer constant of 50 M(-1) was measured in Ringers buffer at pH 7.2, and the response to chemically induced chloride currents was recorded in real time in hippocampal cells.
Chemistry: A European Journal | 2007
Pierluigi Teolato; Enrico Rampazzo; Maria Arduini; Fabrizio Mancin; Paolo Tecilla; Umberto Tonellato
Langmuir | 2007
Maria Arduini; Fabrizio Mancin; Paolo Tecilla; Umberto Tonellato
Langmuir | 2005
Maria Arduini; Silvia Marcuz; Mariachiara Montolli; Enrico Rampazzo; Fabrizio Mancin; Silvia Gross; Lidia Armelao; Paolo Tecilla; Umberto Tonellato
Chemical Communications | 2003
Maria Arduini; Fulvia Felluga; Fabrizio Mancin; Paola Rossi; Paolo Tecilla; Umberto Tonellato; Nicola Valentinuzzi
Inorganica Chimica Acta | 2007
Maria Arduini; Enrico Rampazzo; Fabrizio Mancin; Paolo Tecilla; Umberto Tonellato
Applied Surface Science | 2007
Maria Arduini; Lidia Armelao; Silvia Gross; Fabrizio Mancin; Silvia Marcuz; Mariachiara Montolli; Cinzia Sada