Maria Claudia Gomes Komatsu

Influência da peritonite sobre a síntese de colágeno em anastomoses do cólon distal: estudo experimental em ratos

The purpose of the present study was to evaluate the burst strength and the collagen concentration in a left colonic anastomosis when peritonitis was present. Forty Wistar male rats were used, with a mean age of 120 days and a mean weight of 302 g. The animals were allocated in two groups of 20 animals each: a control group and an experimental group. Under ether anesthesia, the rats of the experimental group were submitted to a laparotomy and the abdominal sepsis was induced according to the Wichterman method, while those in the control group were submitted to laparotomy and manipulation of the intestinal segments involved in the experiment. Twenty four hours later, the animals underwent to a new laparotomy and a left colonic anastomosis, with a single layer of polypropilene interrupted suture, 2,0 cm above the peritoneal reflection. On the 3rd and 7th post-operative day, the colonic segment with the anastomosis was resected in order to evaluate the bursting strength . The Red Sirius dye was used to evaluate collagen concentration in the histopathological study. Results showed in both groups an increase in the bursting strength , relating to post-operative day. Collagen concentration was poorer in the peritonitis group on the 3rd and 7th post-operative days (p = 0.000168) (p = 0.0020) respectively. The percentages of collagen I and III were similar on the 3rd post-operative day. On the 7th day, however, collagen type III (p =0.000079) predominated in the peritonitis group. The results above showed that the concentration and maturation of collagen are reduced in a colonic anastomosis performed when peritonitis is present. These alterations does not interfere in the bursting strength.

Estudo dos conhecimentos de pacientes com hipertensão, diabetes ou glaucoma sobre suas doenças

Purpose: To investigate the level of knowledge among patients with glaucoma about their disease and to compare this group with the number of patients with suspected hypertension or diabetes who know about their disease. Methods: A descriptive study was conducted during the first stage of the Glaucoma Project in 1999 in the municipality of Piraquara, PR, where the local population older than 40 years was submitted to ophthalmologic examination (tonometry and fundoscopy), measurement of arterial pressure, and blood glucose test. Results: A total of 922 individuals were examined. Two hundred and six patients were screened as suspected diabetics; of these, 42.72% (n=88) knew about their disease. We detected 625 patients with suspected hypertension, 60.64% of whom (n=379) declared that they were hypertensive. A hundred and fifty pacients were screened as suspected open angle glaucoma; of these, only 3.33% (n=5) knew about their disease and 96.67% (n=145) were not aware of their disease. Conclusion: The level of knowledge of patients with a diagnosis of glaucoma is extremely low compared to the number of patients with suspected arterial hypertension or diabetes.

Ectrópio palpebral em portador da síndrome de Down e conjuntivite alérgica: relato de caso

This is a case report of a patient with Downs syndrome with an important mechanical ectropion and elongation of the lower lid related to chronic allergic conjunctivitis, besides cataract and keratoconus. The tarsal strip technique and resection of redundant and thick conjunctiva was the surgical approach chosen for this case. Functional and cosmetic outcomes were considered satisfactory.This is a case report of a patient with Downs syndrome with an important mechanical ectropion and elongation of the lower lid related to chronic allergic conjunctivitis, besides cataract and keratoconus. The tarsal strip technique and ressection of redundant and thick conjunctiva was the surgical approach chosen for this case. Functional and cosmetic outcomes were considered satisfactory.

Achados oculares e fundoscópicos em pacientes com lupus eritematoso sistêmico

Purpose: To describe the changes in ocular examination of patients with systemic lupus erythematosus (SLE), especially those related to fundoscopy. Method: A descriptive study of 41 lupus patients selected at random from May to July 1999 at the Collagen Disease Outpatient Clinic of the Rheumatology Service of the University Hospital, Federal University of Parana. A protocol of clinical and ophthalmologic evaluation was applied. Results: Forty-one patients were included in the study; 40 were females (97.56%) and one was a male (2.44%). Mean age was 32.22 years (range: 16 to 54 years). Thirty-seven patients (87.80%) were white, two (4.89%) were black, and three (7.32%) were mulattoes. Time since SLE diagnosis ranged from two months to 18 years. Nineteen of the 41 patients (46.34%) presented fundoscopic alterations related to SLE. The major lesions detected were cotton-wool spots and arteriolar narrowing (68.42%) followed by increased excavation (10.52%) and optic disk pallor (10.52%), perivascular damage (5.26%), and changes in the pigment epithelium of the retina (5.26%). Conclusion: There was a high prevalence of fundoscopic changes related to SLE, showing the importance of regular fundoscopic examinations even in asymptomatic lupus patients or in lupus patients with no associated diseases.

Amaurose bilateral por osteopetrose congênita: relato de caso e revisão da literatura

A osteopetrose congenita e uma rara desordem genetica autossomica recessiva caracterizada por osso esclerotico associado a anormalidades hematologicas e neurologicas. Os autores fazem revisao da literatura e relatam um caso de uma crianca do sexo feminino com 2 anos e 5 meses de vida apresentando amaurose bilateral por osteopetrose congenita.

O pulmão na doença inflamatória do cólon: estudo experimental em ratos

Although ulcerative colitis has been known since 1875 and many extraintestinal manifesattions of this disease have been described, it was only that emphasis was placed on the involvement of the respiratory tract. Severe complications have been described in patients, such as inflammatory tracheal stenosis, bronchiolitis with pnemonia, interstitial pneumonitis, Wegener granulomatosis, chronic bronchitis with bronchiectasis, necrobiotic nodules, vasculitis, fibrosis and alveolitis. The objective of the present study was to determine the pulmonary changes occuring during the acute phase of the disease in rats submitted to induction of the disease with 10% acetic acid and to compared to normal controls. It was observed that 100% of the animals with colitis developed a pulmonary inflammatory reaction (p=0,0210) of moderate to severe intensity (p=0,0340). Vasculitis was observed in 58,33% of the lungs (p=0,0060) and focal hemorrhage, necrosis and abscesses were detected in 3 animals. These findings permit us to conclude about the presence of a strong correlation between inflammatory colon disease and changes in the respiratory apparatus during the acute phase of the disease in rats.