Maria Dobosz
Medical University of Lublin
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Publication
Featured researches published by Maria Dobosz.
Journal of Enzyme Inhibition and Medicinal Chemistry | 2013
Łukasz Popiołek; Urszula Kosikowska; Maria Dobosz; Anna Malm
This study presents the synthesis, spectral analysis and antimicrobial evaluation of a new series of substituted 1,2,4-triazole (5a–i) and 1,3,4-thiadiazole derivatives (9a, c, g, h). New compounds were obtained by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antimicrobial activities. Nine of the compounds had potential activity against Gram-positive bacteria (MIC = 3.91–500 µg/mL). Some compounds showed good activity especially against: Micrococcus luteus ATCC 10240 (MIC = 3.91−31.25 µg/mL), Bacillus subtilis ATCC 6633 (MIC = 15.63− 62.5 µg/mL), and Staphylococcus aureus ATCC 25923 (MIC = 15.63−125 µg/mL).
Phosphorus Sulfur and Silicon and The Related Elements | 2008
Agata Siwek; Monika Wujec; Maria Dobosz; Ewa Jagiełło-Wójtowicz; Agnieszka Kleinrok; Anna Chodkowska; Piotr Paneth
Three 3-(thiophen-2-yl)-4-substituted-Δ 2 -1,2,4-triazoline-5-thiones were synthesized by intramolecular cyclization of 1-(thiophen-2-ylcarbonyl)-4-substituted thiosemicarbazides in alkaline medium. Their effects on the central nervous system (CNS) of mice in some behavioral tests were investigated. All investigated compounds displayed antinociceptive activity. The correlation between the structural features and bioactivity has been discussed.
Heterocycles | 2006
Monika Wujec; Monika Pitucha; Maria Dobosz
In the reaction of hydrazide of (4-phenyl-5-oxo-1,2,4-triazolin-1-yl)-acetic acid (1) with isocyanate the respective semicarbazide derivatives (2) were obtained. Further cyclization with 2% NaOH led to the formation of [3-(4-phenyl-5-oxo-l,2,4-triazolin-l-yl)methyl]-4-substituted 1,2,4-triazolin-5-one (3) and (4-phenyl-5-oxo-1,2,4-triazolin-1-yl)acetic acid (4).
Acta Pharmaceutica | 2004
Monika Wujec; Monika Pitucha; Maria Dobosz; Urszula Kosikowska; Anna Malm
Medicinal Chemistry Research | 2013
Łukasz Popiołek; Urszula Kosikowska; Liliana Mazur; Maria Dobosz; Anna Malm
Collection of Czechoslovak Chemical Communications | 2005
Alicja Maliszewska-Guz; Monika Wujec; Monika Pitucha; Maria Dobosz; Anna Chodkowska; Ewa Jagiełło-Wójtowicz; Liliana Mazur; Anna E. Koziol
Heteroatom Chemistry | 2010
Agata Siwek; Monika Wujec; Maria Dobosz; Irena Wawrzycka-Gorczyca
Phosphorus Sulfur and Silicon and The Related Elements | 2012
Łukasz Popiołek; Urszula Kosikowska; Maria Dobosz; Anna Malm
Heteroatom Chemistry | 2008
Agata Siwek; Monika Wujec; Maria Dobosz; Piotr Paneth
Journal of The Chinese Chemical Society | 2007
Monika Pitucha; Monika Wujec; Maria Dobosz