Maria E. Rodriguez

Neurofibromatosis type 1: A neuro-psycho-cutaneous syndrome?

ABSTRACT Neurofibromatosis type 1 (NF1) is an inherited disorder often associated with optic nerve gliomas, low-grade brain tumors, and readily visible signs. Though these features are frequently emphasized, the psychosocial and emotional morbidities are often overlooked. We present a patient with depressive disorder resulting in suicide in a patient with NF1.

Bilateral Primary Mucinous Carcinoma of the Eyelid.

The aim of this study is to report a case of bilateral primary mucinous carcinoma of the eyelids. This is a case report and literature review. A 71-year-old female presented with primary mucinous carcinoma of the left upper eyelid, which was excised with Mohs surgery. One year later, she developed primary mucinous carcinoma of the right upper eyelid, which was also treated Mohs surgery. Extensive workup was negative for evidence of an unknown primary carcinoma or metastasis. Primary mucinous carcinoma of the eyelids may occur as multifocal tumors, and bilateral disease is not necessarily indicative of metastatic disease.

Is There an Increased Prevalence of Asteroid Hyalosis in Eyes with Uveal Melanoma A Histopathologic Study

During the planning meeting for the Collaborative Ocular Melanoma Study (COMS) prior to the start of patient recruitment in 1986, there was an interest expressed in determining whether a relationship existed between the presence of uveal melanoma (UM) and asteroid hyalosis (AH). To answer this question, the ophthalmic examination form (unlike the pathology form for enucleated eyes) for each COMS patient asked whether AH was present or not. Though an increased prevalence was not found, this result was never published. A recent unpublished study at the University of Wisconsin School of Veterinary Medicine indicated a higher prevalence of AH in canine eyes with UM when compared to control eyes (without tumor) enucleated for goniodysgenesis. This further increased our interest in revisiting the published literature, clinical records, and histopathology slides of the enucleated eyes from the COMS study, as well as the histopathology slides on file in the University of Wisconsin Eye Pathology Laboratory. While cases with both AH and UM were occasionally encountered in the literature, clinically, we could not find a previous study focusing on these two processes. This study was conducted to explore whether such an association exists.

Scleral Necrosis Simulating Recurrent Uveal Melanoma after Plaque Brachytherapy

Supported by the National Eye Institute, National Institutes of Health, Bethesda, Maryland (cooperative agreement nos.: U10 EY017823, U10 EY017825, U10 EY017826, and U10 EY017828). The funding organization participated in the design and conduct of the study, data analysis and interpretation, and review of the manuscript. Author Contributions: Conception and design: Maguire, Martin, Ying, Jaffe, Daniel, Toth, Grunwald, Fine Analysis and interpretation: Maguire, Martin, Ying, Jaffe, Daniel, Toth, Grunwald, Ferris, Fine Data collection: Maguire, Martin, Ying, Jaffe, Daniel, Toth, Grunwald, Ferris, Fine

Histologic Changes in a Squamous Cell Carcinoma of Conjunctiva Refractive to Interferon-α2b

MD). Bausch & Lomb (Rochester, NY) provided support to the study in the form of donation of fluocinolone implants for patients randomized to implant therapy who were uninsured or otherwise unable to pay for implants, or who were located at a site where implants could not be purchased (e.g., the United Kingdom). Additional support was provided by Research to Prevent Blindness, Inc., New York, NY; the Paul and Evanina Mackall Foundation (Chicago, IL); and the Lois Pope Life Foundation (Delray Beach, FL). A representative of the National Eye Institute participated in the conduct of the study, including the study design; collection, management, analysis, and interpretation of the data; and review and approval of this manuscript. The sponsor or funding organization had no role in the design or conduct of this research.

Corneal Leukoma with Features of Both Sclerocornea and Peter's Anomaly.

Analysis and interpretation: Shim, Sung, J.M.Kim, Lee,Won, J.H. Kim, Park Obtained funding: Not applicable Overall responsibility: Shim, J.M. Kim Abbreviations and Acronyms: BMI 1⁄4 body mass index; CDR 1⁄4 cup-to-disc ratio; CI 1⁄4 confidence interval; CG 1⁄4 CockcrofteGault; CKD 1⁄4 chronic kidney disease; eGFR 1⁄4 estimated glomerular filtration rate; FDT 1⁄4 frequency doubling technology; GFR 1⁄4 glomerular filtration rate; HDL 1⁄4 high-density lipo-

Adult-onset asthma and periocular xanthogranulomas associated with systemic IgG4-related disease

Purpose The aim of this study was to report a case of Adult-Onset Asthma with Periocular Xanthogranulomas (AAPOX) associated with systemic IgG4-related disease (IgG4-RD). Observations A 57-year-old man presented with bilateral periorbital swelling for 1 year. Histopathology of a left orbital biopsy showed fibro vascular connective tissue inundated with foamy, lipid-laden histiocytes and touton giant cells with lymphocytic inflammation. Additional stains revealed CD68 positivity, and S100 negativity. The IgG and IgG4 stained slides showed increased IgG4 positive plasma cells but did not meet the criteria for IgG4-related orbital disease. His IgG4 serology was elevated, and IgG4 staining of his tissue previously diagnosed as autoimmune sclerosing pancreatitis was found to meet the criteria for IgG4-RD. Conclusion and importance AAPOX can be associated with systemic IgG4-RD.

Papillomatous Compound Nevus.

Papillomatous Compound Nevus An 8-year-old boy was observed for 5 years for an enlarging, pigmented lesion on his left lower lid (Fig 1). An excisional biopsy was performed and histopathology (H&E) revealed skin with keratinized, stratified squamous epithelium in a papillomatous configuration (Figs 2 and 3). The lesion had nests of densely pigmented melanocytes within the epithelium (black arrows), at the epithelial-stromal junction (white arrows) and within the underlying stroma (asterisks). The history of growth and the junctional location are of much less concern in a juvenile nevus than in an adult nevus.

Follicular Hybrid Cyst of the Eyelid

Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (J.E.T.); the Skirball Foundation, New York, New York (G.N.H.); and the Stein Eye Institute Herb Ritts, Jr., Memorial Vision Fund, New York, New York (G.N.H.). The funding organizations had no role in the design or conduct of this research. Author Contributions: Conception and design: Ashraf, Holland, Van Natta, Wu, Thorne, Jabs Analysis and interpretation: Ashraf, May, Holland, Van Natta, Wu, Thorne, Jabs Data collection: Holland, Van Natta, Thorne, Jabs Obtained funding: none Overall responsibility: Ashraf, May, Holland, Van Natta, Wu, Thorne, Jabs