María Elena Maldonado

Mango de azúcar (Mangifera indica), variedad de Colombia: características antioxidantes, nutricionales y sensoriales

The sugar mango is a small Colombian cultivar with low fiber content, good aroma and flavor. This research evaluated antioxi dant capacity (FRAP, DPPH) of the fruit at different ripening stages classified by visual inspection and CIELab scale. Nutritional and sensory characteristics and ORAC value were measured in the ripe fruit. Sensorial characteristics of two mango nectars sweetened with sucrose and sucralose using ripe fruit were determined by affective acceptance test and Hedonic scale. Results showed that classification by visual inspection coincided with the CIELab scale for all ripening stages. The green mango has 45% more flavonoids than the mature one. The carotenoid content, DPPH and FRAP values were similar in the different ripening stages. Sucralose sweetened nectar was accepted by 94.9% compared with that sweetened with sucrose (89.1%). Results indicate that mango sugar fruit and nectar present antioxidant capacity, bioactive and nutritional compounds with potential health benefits.

Synthesis and antiproliferative activity of 3- and 7-styrylcoumarins

A series of styrylcoumarins were obtained via Mizoroki-Heck reactions between 3-bromo-4-methyl-7-(octyloxy)-2H-chromen-2-one or 2-oxo-2H-chromen-7-yl trifluoromethanesulfonate and functionalized styrenes. The structures of the products were elucidated by spectroscopic analysis. All compounds were evaluated against SW480 and CHO-K1 cell lines. A number of hybrids showed good antiproliferative activity. Among the tested compounds, hybrids 6e, 10c, and 10d, exhibited the highest activity (IC50- SW480/48h = 6,92; 1,01 and 5,33 µM, respectively) and selectivity (IS48h = >400; 67,8 and 7,2, respectively). In addition, these compounds were able to preserve their activities over time. The results achieved by these hybrids were even better than the lead compounds (coumarin and resveratrol) and the standard drug (5-FU). As regards structure-activity relationship it seems that the location of the styryl group on the coumarin structure and the presence of the hydroxyl group on the phenyl ring were determinant for the activity.