Maria Elisa Serrano Navacerrada
University of Liège
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Publication
Featured researches published by Maria Elisa Serrano Navacerrada.
PLOS ONE | 2016
Catherine Menten; Maria Elisa Serrano Navacerrada; Odile Bartholomé; J.S Gil; Virginie Neirinckx; Sabine Wislet; Guillaume Becker; Alain Plenevaux; Priscilla Van den Ackerveken; Bernard Rogister
SV2A is a glycoprotein present in the membranes of most synaptic vesicles. Although it has been highly conserved throughout evolution, its physiological role remains largely unknown. Nevertheless, Levetiracetam, a very effective anti-epileptic drug, has been recently demonstrated to bind to SV2A. At present, our understanding of the normal function of SV2A and its possible involvement in diseases like epilepsy is limited. With this study, we sought to develop a relevant model enabling analysis of SV2A’s role in the occurrence or progression of epilepsy. For this purpose, we generated a floxed SV2A mouse model with conditional alleles carrying LoxP sites around exon 3 by means of a gene-targeting strategy. The SV2A lox/lox mouse line is indistinguishable from wild-type mice. When the recombination was observed in all cells, a model of mice with both SV2A alleles floxed around exon 3 recapitulated the phenotype of SV2A KO mice, including seizures. However, the specific invalidation of SV2A in the CA3 hippocampal region was not followed by epileptic seizures or decrease in the epileptic threshold on pentylenetetrazol (PTZ) test. These results demonstrate that the floxed SV2A mouse line has been successfully established. This transgenic mouse model will be useful for investigating SV2A functions related to cell types and developmental stages.
Archive | 2018
Guillaume Becker; Louis-Ferdinand Lespine; Jérôme Bruneel; Maria Elisa Serrano Navacerrada; André Luxen; Ezio Tirelli; Alain Plenevaux; Mohamed Ali Bahri
Archive | 2018
Maria Elisa Serrano Navacerrada; Mohamed Ali Bahri; Guillaume Becker; Corentin Warnier; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; André Luxen; Alain Plenevaux
Archive | 2017
Guillaume Becker; Corentin Warnier; Maria Elisa Serrano Navacerrada; Mohamed Ali Bahri; Joël Mercier; André Luxen; Christian Lemaire; Eric Salmon; Alain Plenevaux
Archive | 2017
Maria Elisa Serrano Navacerrada; Guillaume Becker; Mohamed Ali Bahri; Corentin Warnier; Joël Aerts; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Archive | 2017
Maria Elisa Serrano Navacerrada; Guillaume Becker; Mohamed Ali Bahri; Corentin Warnier; Joël Aerts; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Archive | 2017
Maria Elisa Serrano Navacerrada; Odile Bartholomé; Priscilla Van den Ackerveken; Bernard Rogister; Alain Plenevaux; Ezio Tirelli
Archive | 2017
Maria Elisa Serrano Navacerrada; Guillaume Becker; Mohamed Ali Bahri; Corentin Warnier; Joël Aerts; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Archive | 2017
Maria Elisa Serrano Navacerrada; Guillaume Becker; Mohamed Ali Bahri; Corentin Warnier; Joël Aerts; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux
Epilepsia | 2017
Maria Elisa Serrano Navacerrada; Guillaume Becker; Mohamed Ali Bahri; Corentin Warnier; Joël Aerts; Frédéric Mievis; Fabrice Giacomelli; Christian Lemaire; Eric Salmon; André Luxen; Alain Plenevaux