Maria Eugenia Caligiuri
National Research Council
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Featured researches published by Maria Eugenia Caligiuri.
Neuroinformatics | 2015
Maria Eugenia Caligiuri; Paolo Perrotta; Antonio Augimeri; Federico Rocca; Aldo Quattrone; Andrea Cherubini
White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly subjects and patients with several neurological and vascular disorders. A truly reliable and fully automated method for quantitative assessment of WMH on magnetic resonance imaging (MRI) has not yet been identified. In this paper, we review and compare the large number of automated approaches proposed for segmentation of WMH in the elderly and in patients with vascular risk factors. We conclude that, in order to avoid artifacts and exclude the several sources of bias that may influence the analysis, an optimal method should comprise a careful preprocessing of the images, be based on multimodal, complementary data, take into account spatial information about the lesions and correct for false positives. All these features should not exclude computational leanness and adaptability to available data.
Movement Disorders | 2014
Andrea Cherubini; Maurizio Morelli; Rita Nisticò; Maria Salsone; Gennarina Arabia; Roberta Vasta; Antonio Augimeri; Maria Eugenia Caligiuri; Aldo Quattrone
The aim of the current study was to distinguish patients with Parkinson disease (PD) from those with progressive supranuclear palsy (PSP) at the individual level using pattern recognition of magnetic resonance imaging data.
NeuroImage: Clinical | 2015
Maria Eugenia Caligiuri; Stefania Barone; Andrea Cherubini; Antonio Augimeri; Carmelina Chiriaco; Maria Trotta; Alfredo Granata; Enrica Filippelli; Paolo Perrotta; Paola Valentino; Aldo Quattrone
Significant corpus callosum (CC) involvement has been found in relapsing–remitting multiple sclerosis (RRMS), even if conventional magnetic resonance imaging measures have shown poor correlation with clinical disability measures. In this work, we tested the potential of multimodal imaging of the entire CC to explain physical and cognitive disability in 47 patients with RRMS. Values of thickness, fractional anisotropy (FA) and mean diffusivity (MD) were extracted from 50 regions of interest (ROIs) sampled along the bundle. The relationships between clinical, neuropsychological and imaging variables were assessed by using Spearmans correlation. Multiple linear regression analysis was employed in order to identify the relative importance of imaging metrics in modeling different clinical variables. Regional fiber composition of the CC differentially explained the response variables (Expanded Disability Status Scale [EDSS], cognitive impairment). Increases in EDSS were explained by reductions in CC thickness and MD. Cognitive impairment was mainly explained by FA reductions in the genu and splenium. Regional CC imaging properties differentially explained disability within RRMS patients revealing strong, distinct patterns of correlation with clinical and cognitive status of patients affected by this specific clinical phenotype.
Human Brain Mapping | 2017
Gaetano Barbagallo; Maria Eugenia Caligiuri; Gennarina Arabia; Andrea Cherubini; Angela Lupo; Rita Nisticò; Maria Salsone; Fabiana Novellino; Maurizio Morelli; Giuseppe Lucio Cascini; Domenico Galea; Aldo Quattrone
Motor phenotypes of Parkinsons disease (PD) are recognized to have different prognosis and therapeutic response, but the neural basis for this clinical heterogeneity remains largely unknown. The main aim of this study was to compare differences in structural connectivity metrics of the main motor network between tremor‐dominant and nontremor PD phenotypes (TD‐PD and NT‐PD, respectively) using probabilistic tractography‐based network analysis. A total of 63 PD patients (35 TD‐PD patients and 28 NT‐PD patients) and 30 healthy controls underwent a 3 T MRI. Next, probabilistic tractography‐based network analysis was performed to assess structural connectivity in cerebello‐thalamo‐basal ganglia‐cortical circuits, by measuring the connectivity indices of each tract and the efficiency of each node. Furthermore, dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) with 123I‐ioflupane was used to assess dopaminergic striatal depletion in all PD patients. Both PD phenotypes showed nodal abnormalities in the substantia nigra, in agreement with DAT‐SPECT evaluation. In addition, NT‐PD patients displayed connectivity alterations in nigro‐pallidal and fronto‐striatal pathways, compared with both controls and TD‐PD patients, in which the same motor connections seemed to be relatively spared. Of note, in NT‐PD group, rigidity‐bradykinesia score correlated with fronto‐striatal connectivity abnormalities. These findings demonstrate that structural connectivity alterations occur in the cortico‐basal ganglia circuit of NT‐PD patients, but not in TD‐PD patients, suggesting that these anatomical differences may underlie different motor phenotypes of PD. Hum Brain Mapp 38:4716–4729, 2017.
Brain | 2018
Christopher D. Whelan; Andre Altmann; Juan A. Botia; Neda Jahanshad; Derrek P. Hibar; Julie Absil; Saud Alhusaini; Marina K. M. Alvim; Pia Auvinen; Emanuele Bartolini; Felipe P. G. Bergo; Tauana Bernardes; Karen Blackmon; Barbara Braga; Maria Eugenia Caligiuri; Anna Calvo; Sarah J. Carr; Jian Chen; Shuai Chen; Andrea Cherubini; Philippe David; Martin Domin; Sonya Foley; Wendy França; Gerrit Haaker; Dmitry Isaev; Simon S. Keller; Raviteja Kotikalapudi; Magdalena A. Kowalczyk; Ruben Kuzniecky
Structural MRI abnormalities are inconsistently reported in epilepsy. In the largest neuroimaging study to date, Whelan et al. report robust structural alterations across and within epilepsy syndromes, including shared volume loss in the thalamus, and widespread cortical thickness differences. The resulting neuroanatomical map will guide prospective studies of disease progression.
IEEE Journal of Biomedical and Health Informatics | 2016
Andrea Cherubini; Maria Eugenia Caligiuri; Patrice Péran; Umberto Sabatini; Carlo Cosentino; Francesco Amato
This study presents a voxel-based multiple regression analysis of different magnetic resonance image modalities, including anatomical T1-weighted, T2* relaxometry, and diffusion tensor imaging. Quantitative parameters sensitive to complementary brain tissue alterations, including morphometric atrophy, mineralization, microstructural damage, and anisotropy loss, were compared in a linear physiological aging model in 140 healthy subjects (range 20-74 years). The performance of different predictors and the identification of the best biomarker of age-induced structural variation were compared without a priori anatomical knowledge. The best quantitative predictors in several brain regions were iron deposition and microstructural damage, rather than macroscopic tissue atrophy. Age variations were best resolved with a combination of markers, suggesting that multiple predictors better capture age-induced tissue alterations. The results of the linear model were used to predict apparent age in different regions of individual brain. This approach pointed to a number of novel applications that could potentially help highlighting areas particularly vulnerable to disease.
European Journal of Neurology | 2015
Roberta Vasta; Maria Eugenia Caligiuri; Angelo Labate; Andrea Cherubini; Laura Mumoli; Edoardo Ferlazzo; Paolo Perrotta; Pierluigi Lanza; Antonio Augimeri; Umberto Aguglia; Aldo Quattrone; Antonio Gambardella
To evaluate if an automatic magnetic resonance imaging (MRI) processing system may improve detection of hippocampal sclerosis (Hs) in patients with mesial temporal lobe epilepsy (MTLE).
Movement Disorders | 2016
Maria Eugenia Caligiuri; Rita Nisticò; Gennarina Arabia; Maurizio Morelli; Fabiana Novellino; Maria Salsone; Gaetano Barbagallo; Angela Lupo; Giuseppe Lucio Cascini; Domenico Galea; Andrea Cherubini; Aldo Quattrone
Several neuroimaging studies have been carried out to gain insight on the pathological processes that cause PD, but literature findings are inconsistent. The aim of this study was to combine information carried by functional imaging with DA transporter ligands and structural MRI.
Epilepsia | 2016
Maria Eugenia Caligiuri; Angelo Labate; Andrea Cherubini; Laura Mumoli; Edoardo Ferlazzo; Umberto Aguglia; Aldo Quattrone; Antonio Gambardella
Corpus callosum (CC) abnormalities are frequently reported in patients with refractory mesial temporal lobe epilepsy (rMTLE). However, whether CC structural alterations are related to the epileptic syndrome itself or to refractoriness is still unknown. Thus, we aimed to compare patterns of CC change in patients with rMTLE and benign MTLE (bMTLE), the latter of which represents a useful resource to better disentangle factors that contribute to refractoriness.
American Journal of Neuroradiology | 2016
Giuseppe Nicoletti; Maria Eugenia Caligiuri; Andrea Cherubini; M. Morelli; Fabiana Novellino; Gennarina Arabia; Maria Salsone; Aldo Quattrone
BACKGROUND AND PURPOSE: The superior cerebellar peduncle is damaged in progressive supranuclear palsy. However, alterations differ between progressive supranuclear palsy with Richardson syndrome and progressive supranuclear palsy-parkinsonism. In this study, we propose an automated tool for superior cerebellar peduncle integrity assessment and test its performance in patients with progressive supranuclear palsy with Richardson syndrome, progressive supranuclear palsy-parkinsonism, Parkinson disease, and healthy controls. MATERIALS AND METHODS: Structural and diffusion MRI was performed in 21 patients with progressive supranuclear palsy with Richardson syndrome, 9 with progressive supranuclear palsy-parkinsonism, 20 with Parkinson disease, and 30 healthy subjects. In a fully automated pipeline, the left and right superior cerebellar peduncles were first identified on MR imaging by using a tractography-based atlas of white matter tracts; subsequently, volume, mean diffusivity, and fractional anisotropy were extracted from superior cerebellar peduncles. These measures were compared across groups, and their discriminative power in differentiating patients was evaluated in a linear discriminant analysis. RESULTS: Compared with those with Parkinson disease and controls, patients with progressive supranuclear palsy with Richardson syndrome showed alterations of all superior cerebellar peduncle metrics (decreased volume and fractional anisotropy, increased mean diffusivity). Patients with progressive supranuclear palsy-parkinsonism had smaller volumes than those with Parkinson disease and controls and lower fractional anisotropy than those with Parkinson disease. Patients with progressive supranuclear palsy with Richardson syndrome had significantly altered fractional anisotropy and mean diffusivity in the left superior cerebellar peduncle compared with those with progressive supranuclear palsy-parkinsonism. Discriminant analysis with the sole use of significant variables separated progressive supranuclear palsy-parkinsonism from progressive supranuclear palsy with Richardson syndrome with 70% accuracy and progressive supranuclear palsy-parkinsonism from Parkinson disease with 74% accuracy. CONCLUSIONS: We demonstrate the feasibility of an automated approach for extracting multimodal MR imaging metrics from the superior cerebellar peduncle in healthy subjects and patients with parkinsonian. We provide evidence that structural and diffusion measures of the superior cerebellar peduncle might be valuable for computer-aided diagnosis of progressive supranuclear palsy subtypes and for differentiating patients with progressive supranuclear palsy-parkinsonism from with those with Parkinson disease.