Maria Heliana Chaves Monteiro da Cunha

Fatores de risco em contatos intradomiciliares de pacientes com hanseníase utilizando variáveis clínicas, sociodemográficas e laboratoriais

Programa Institucional de Bolsas de Iniciacao Cientifica, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (PIBIC/CNPq/UFPA).

Recidiva hansênica em área de alta endemicidade no Estado do Pará, Brasil

It is considered as a case of leprosy relapse, the individual who, after having been discharged for healing, has presented clinical signs of disease activity. In order to know the occurrence of relapse, clinical and epidemiological factors in patients in a hyperendemic region, a survey was conducted which methods comprise an epidemiological cross-sectional descriptive study from January 2007 to December 2008, with data provided by Specialized Reference Center (Unidade de Referência Especializada – URE) in leprosy Dr. Marcello Candia, in Pará State, Brazil. The results of the study revealed that 96.3% of 27 patients belonged to the multibacillary classification, predominantly male (74.1%), with the age group from 29 to 42 years old (44.4%), most came from Belém metropolitan region (70.4%). The clinical manifestation characterized by new lesions (81.5%), with time of appearance between five and ten years (55.6%). The diagnosis used clinical and bacteriological index assessment (63%), of these 40.7% were smear between 4-6+. The degree of disability in 44.4% was not recorded at the beginning of treatment. The cases of leprosy diagnosed and treated at URE Dr. Marcello Candia, mostly, met the criteria established by Brazilian Ministry of Health. The degree of disability of some patients did not show the result in this evaluation, which it is very important to prevent disabilities. The simplified dermatological assessment recommended by Ministry of Health should be reinforced in its importance in all services that have leprosy patients, since it is essential for the early diagnosis of neurological damage.

Perfil de anticorpos anti-PGL-1 em indivíduos sadios de áreas endêmicas para a hanseníase do Estado do Pará, Brasil

El objetivo de este estudio fue el de describir el perfil de anticuerpos, IgM, anti-PGL-1, metodo de ELISA, en donantes de sangre de areas de muy alta endemicidad e hiperendemicas en hanseniasis en el Estado de Para, Brasil, utilizando punto de corte (PC) ≥ 0,20. Otros objetivos fueron los de correlacionar los niveles de anticuerpos anti-PGL-1 a factores demograficos y la vacuna BCG e identificar el PC para la prueba anti-PGL-1 con base en el promedio de los niveles hallados. Los resultados no mostraron significancia estadistica entre sexo, edad, presencia de cicatriz de BCG y los niveles de anti-PGL-1. Se identificaron tres PCs: general, por hemocentro y por municipios. Con PC ≥ 0,13 (general), la seropositividad en las variables fue el doble en numeros absolutos, de 15 para 36, resultado estadisticamente no significativo (p > 0,05). El promedio de los niveles de anti-PGL-1 fue muy bajo para areas de parametros elevados, y no reflejaron la magnitud de la endemicidad de la hanseniasis en esas areas. El PC mas bajo se presento mas adecuado al comportamiento serologico identificado