Maria Luisa Bertrand

Management of calcaneal fractures: what have we learnt over the years?

Calcaneal fractures result, in many cases, in, subtalar joint stiffness and severe disability. Diagnosis is usually made by X-ray, but more accurately by a computed tomography (CT) scan. In the last years, much has been known regarding its physiopathology and osteosynthesis. Although new developments in osteosynthesis materials have been made, calcaneus fractures still remains in dispute of those advocating non-operative treatment and those defending open reduction and internal fixation. Less invasive surgery, arthroscopy and three-dimensional (3D) fluoroscopy are very important for reduction accuracy and soft-tissue damage avoidance. In this article, the physiopathology, diagnosis, classification and treatment of calcaneus fractures are updated. Nevertheless, systematic reviews have shown no evidence about what treatment is better.

Autologous human-derived bone marrow cells exposed to a novel TGF-β1 fusion protein for the treatment of critically sized tibial defect

We report the first clinical case of transplantation of autologous bone marrow-derived cells in vitro exposed to a novel recombinant human transforming growth factor (rhTGF)-beta1 fusion protein bearing a collagen-binding domain (rhTGF-beta(1)-F2), dexamethasone (DEX) and beta-glycerophosphate (beta-GP). When such culture-expanded cells were loaded into porous ceramic scaffolds and transplanted into the bone defect of a 69-year-old man, they differentiated into bone tissue. Marrow cells were obtained from the iliac crest and cultured in collagen gels impregnated with rhTGF-beta1-F2. Cells were selected under serum-restricted conditions in rhTGF-beta(1)-F2-containing medium for 10 days, expanded in 20% serum for 22 days and osteoinduced for 3 additional days in DEX/beta-GP-supplemented medium. We found that the cell number harvested from rhTGF-beta(1)-F2-treated cultures was significantly higher (2.3- to 3-fold) than that from untreated cultures. rhTGF-beta(1)-F2 treatment also significantly increased alkaline phosphatase activity (2.2- to 5-fold) and osteocalcin synthesis, while calcium was only detected in rhTGF-beta(1)-F2-treated cells. Eight weeks after transplantation, most of the scaffold pores were filled with bone and marrow tissue. When we tested the same human cells treated in vitro in a rat model using diffusion chambers, there was subsequent development of cartilage and bone following the subcutaneous transplantation of rhTGF-beta(1)-F2-treated cells. This supports the suggestion that such cells were marrow-derived cells, with chondrogenic and osteogenic potential, whereas the untreated cells were not under the same conditions. The ability for differentiation into cartilage and bone tissues, combined with an extensive proliferation capacity, makes such a marrow-derived stem cell population valuable to induce bone regeneration at skeletal defect sites.

The diagnosis of periprosthetic infection.

Periprosthetic infection (PJI) is the most serious joint replacement complication, occurring in 0.8-1.9% of knee arthroplasties and 0.3-1.7% of hip arthroplasties. A definition of PJI was proposed in the November 2011 issue of the journal Clinical Orthopedics and Related Research. The presence of a fistula or of local inflammatory signs is indicative of PJI, but in many cases local pain is the only symptom. In the absence of underlying inflammatory conditions, C-reactive protein measurement is the most useful preoperative blood test for detecting infection associated with a prosthetic joint. The most useful preoperative diagnostic test is the aspiration of synovial joint fluid to obtain a total and differential cell count and culture. Intraoperative frozen sections of periprosthetic tissues produce excellent accuracy in predicting a diagnosis of PJI but only moderate accuracy in ruling out the diagnosis. In this process, obtaining a quality sample is the first step, and determines the quality of microbiological results. Specimens for culture should be obtained prior to the initiation of antibiotic treatment. Sonication of a removed implant may increase the culture yield. Plain radiography has low sensitivity and low specificity for detecting infection associated with a prosthetic joint. Computed tomography and magnetic resonance imaging may be useful in the evaluation of complex cases, but metal inserts interfere with these tests, and abnormalities may be non-specific. Labelled-leucocyte imaging (e.g., leucocytes labelled with indium-111) combined with bone marrow imaging with the use of technetium-99m–labelled sulphur colloid is considered the imaging test of choice when imaging is necessary.

How many distal bolts should be used in unreamed intramedullary nailing for diaphyseal tibial fractures

INTRODUCTION Unreamed intramedullary nailing (UIMN) is an effective treatment procedure for the majority of tibial fractures, with locking constituting the technical support for the buttressing and neutralisation principles underlying intramedullary nailing. It has been claimed that the added versatility obtained from the use of more bolts in distal locking is very important. Several studies have been made concerning the optimum number of locking bolts in distal tibial fractures; however, to the best of our knowledge, no study has dealt with the question of whether two or three bolts should be used in diaphyseal fractures. MATERIAL AND METHODS In this paper, we evaluate the results of treating 86 diaphyseal tibial fractures (type 42 according to the AO classification) with Expert Tibial UIMN (Synthes™, West Chester, PA, USA) and distal blocking with either two or three bolts. Mean patient age was 35 years (21-51). RESULTS We found that the consolidation time is shorter, less radiation time is needed and the material cost is lower when two bolts are used. No other differences were found regarding mean operative time, wound healing, pain at fracture site, joint function, angular deviation or rotation. CONCLUSIONS For type 42 AO tibial fractures treated with Expert Tibial UIMN, distal blocking should be performed with only two bolts.

Resuscitation of Polytrauma Patients: The Management of Massive Skeletal Bleeding.

The term ‘severely injured patient’ is often synonymous of polytrauma patient, multiply-injured patient or, in some settings, polyfractured patient. Together with brain trauma, copious bleeding is the most severe complication of polytrauma. Consequently hypotension develop. Then, the perfusion of organs may be compromised, with the risk of organ failure. Treatment of chest bleeding after trauma is essential and is mainly addressed via surgical manoeuvres. As in the case of lesions to the pelvis, abdomen or extremities, this approach demonstrates the application of damage control (DC). The introduction of sonography has dramatically changed the diagnosis and prognosis of abdominal bleeding. In stable patients, a contrast CT-scan should be performed before any x-ray projection, because, in an emergency situation, spinal or pelvic fractures be missed by conventional radiological studies. Fractures or dislocation of the pelvis causing enlargement of the pelvic cavity, provoked by an anteroposterior trauma, and in particular cases presenting vertical instability, are the most severe types and require fast stabilisation by closing the pelvic ring diameter to normal dimensions and by stabilising the vertical shear. Controversy still exists about whether angiography or packing should be used as the first choice to address active bleeding after pelvic ring closure. Pelvic angiography plays a significant complementary role to pelvic packing for final haemorrhage control. Apart from pelvic trauma, fracture of the femur is the only fracture provoking acute life-threatening bleeding. If possible, femur fractures should be immobilised immediately, either by external fixation or by a sheet wrap around both extremities.

Is There Still a Place for Continuous Closed Irrigation in the Management of Periprosthetic Total Knee Infection

In recent decades, many technical improvements have been achieved in the use of prosthetic joints, and the risk of infection has been greatly reduced, to current rates of 0.4-2.0% following primary knee replacement. However, the increasing rate of joint replacements being performed means that the absolute number of such infections remains significant and poses substantial costs to healthcare systems worldwide. Accordingly, further strategies to treat and prevent total joint infections should be investigated. Infections following knee replacements can compromise the function and durability of arthroplasty. When these infections occur during the immediate postoperative period, irrigation and debridement with component retention can be attempted to salvage the implant. This is an attractive, cheap, low-morbidity treatment for periprosthetic knee infection. However, the results published regarding this procedure are uneven; some studies report the eradication of prosthetic joint infection by debridement alone in 70-90% of cases but conversely, others have reported a high failure rate for this procedure, averaging 68% (61-82%). The difference could be attributed in part to the multiplicity of variables that may influence the success of the procedure. One such is that of treatment with a continuous irrigation system, which has the theoretical advantage of enabling the administration of antimicrobial agents, as well as the drainage of debris and blood clots. The objective of this study is to elucidate the overall efficacy of irrigation and debridement with prosthesis retention in infected total knee arthroplasty and to determine whether the addition of a continuous irrigation system influences this efficacy.

Severe tibial plateau fractures (Schatzker V–VI): open reduction and internal fixation versus hybrid external fixation

Tibial plateau fractures (TPF) are highly prone to complications and adverse effects. Their treatment has long been a matter of controversy, as fracture patterns and possible damage to soft tissues can easily aggravate complications. On the one hand, open reduction and internal fixation (ORIF) techniques provide a good approach to joint shape restoration and biomechanics, but they may also provoke a higher rate of soft-tissue complications. On the other, hybrid external fixation (HEF), although allowing little facility for reduction, may, theoretically, produce much less damage to the soft tissues. We present 93 cases of TPF classified as type V or VI that were followed up for at least 24 months. There were no statistical differences among them in relation to consolidation, secondary malalignment or range of motion, according to whether ORIF or HEF was employed. However, when external fixation followed open reduction, both superficial and deep-infection rates were higher.

Malalignment in intramedullary nailing. How to achieve and to maintain correct reduction

Intramedullary nailing has become the standard for the treatment of long bones diaphyseal fractures. Modern techniques of locking have further enlarged the primary indications to more proximal and distal fractures relying upon a former correct alignment. Nevertheless, residual deformities are not rare as once the nail has left the narrow diaphyseal canal and comes into the wider metaphysis, it may follow an unwished trajectory. There is also a chance for malreduction in diapyhseal fractures. The more complex the fracture is, the more difficult its reduction, not only for the alignment of the proximal or the distal part of bone in relation to the diaphysis, but also correct rotation and length. In this paper, we analyze recommended techniques to achieve accurate bone fracture reduction, to avoid post-operative deformities combined with correct implant insertion.

Allograft plus OP-1 enhances ossification in posterolateral lumbar fusion: A seven year follow-up

PURPOSE To study the results of the combination of allograft plus BMP-7 in comparison with allograft alone in posterolateral lumbar arthrodesis. PATIENTS AND METHODS A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwent posterolateral lumbar instrumented arthrodesis. Allograft randomly compacted onto either the right or the left side of the articular and the posterior aspect of the transverse processes of lumbar spine. The same procedure performed on the contralateral side, but allograft was previously mixed with osteogenic protein (OP-1). Clinical, x-ray and CT-scan long follow-up performed. Univariable and multivariable logistic regression analyses. RESULTS More bone continuity was found with allograft plus OP-1 than with allograft alone (p>0.0038). The amount of bone mass was greater on the OP-1 side (p<0.001). No local or systemic adverse effect were noted. CONCLUSIONS Allograft on one side plus allograft with BMP-7 on the other achieved a fusion rate of 93 per cent. Allograft combined with BMP-7 was more effective than allograft alone.

Reply to comments by Li et al.: “Do the specialist hip unit surgeons have no significant influence on reducing rates of surgical site infection?”

1. The surgical techniques were classified into osteosynthesis and arthroplasties. Dr. Li et al. consider that, in general, hemiarthroplasty and total hip arthroplasty may obtain differences in infection rates. We concur with this view, but what is important in our paper is whether there were significant differences in surgical procedures between the two groups of surgeons. If so, this could have introduced a bias in our study. Table 1 clearly shows that there were no differences between the groups (p=0.146). The same conclusion is drawn regarding possible differences between hemiarthroplasty and total hip replacement in proclivity to infection according to co-morbidities. In this variable, too, there were no differences between the two groups of surgeons (p=0.588). Therefore, we believe that as there were no differences according to type of operation and co-morbidities, the chance of the patient developing an infection is, a priori, the same for both groups of surgeons. 2. We also believe, like Dr. Li et al., that some other variables, such as the duration of surgery or the preoperative haemoglobin level, might affect infection rates. Indeed, many other variables, including cementation, antibiotics and residency, might be considered. We have many such variables recorded in our database but in this study the number of variables was limited in order to conform with the aim of this paper (and also to prevent it from becoming too long for publication). In any case, although interesting, extending the list of variables discussed in this paper could be justified if the conclusions reached led us to support either the operative or the alternative hypothesis, but not the null one (i.e. that the rate of infection is not significant for both groups). On the other hand, the paper of Rasouli et al. [2] cited by Dr. Li et al. concerns revision surgery and includes both hip and knee surgery; in other words, it does not concentrate on the primary treatment of hip fractures, as ours does. This is also the case of another paper cited by Dr. Li et al., that of Dale et al. [3], which discusses the situation of already-infected patients in revision surgery, not that of non-infected hip fractures treated by primary osteosynthesis or arthroplasty, which is the core concern of our paper. As we observe in the “Material and methods” section, patients undergoing reinterventions were excluded unless an infection had developed as a result of the first surgery. 3. In the last paragraph, Dr. Li et al. pose two interesting questions: on the one hand, the possibility that the sample size of 814 patients might not be large enough for statistical analysis; and on the other, the fact that in a paper by Harrison et al. [4] (also cited by Dr. Li et al.), it was found that differences between surgeons were significant. In relation to the first question: unlike the papers cited above, we stratified to a very E. Guerado (*) : J. Cano : E. Cruz :M. Bertrand :M. Hirschfeld Department of Orthopaedic Surgery and Traumatology, Hospital Costa del Sol, University of Malaga, 29603 Marbella, Malaga, Spain e-mail: eguerado@hcs.es