Maria Mody

Auditory temporal perception deficits in the reading-impaired: A critical review of the evidence

We assess evidence and arguments brought forward by Tallal (e.g., 1980) and by the target paper (Farmer & Klein, 1995) for a general deficit in auditory temporal perception as the source of phonological deficits in impaired readers. We argue that (1) errors in temporal order judgment of both syllables and tones reflect difficulty in identifying similar (and so readily confusable) stimuli rapidly, not in judging their temporal order; (2) difficulty in identifying similar syllables or tones rapidly stem from independent deficits in speech and nonspeech discriminative capacity, not from a general deficit in rate of auditory perception; and (3) the results of dichotic experiments and studies of aphasics purporting to demonstrate left-hemisphere specialization for nonspeech auditory temporal perception are inconclusive. The paper supports its arguments with data from a recent control study. We conclude that, on the available evidence, the phonological deficit of impaired readers cannot be traced to any co-occurring nonspeech deficits so far observed and is phonetic in origin, but that its full nature, origin, and extent remain to be determined.

Neuroimaging of the functional and structural networks underlying visuospatial vs. linguistic reasoning in high-functioning autism.

High-functioning individuals with autism have been found to favor visuospatial processing in the face of typically poor language abilities. We aimed to examine the neurobiological basis of this difference using functional magnetic resonance imaging and diffusion tensor imaging. We compared 12 children with high functioning autism (HFA) to 12 age- and IQ-matched typically developing controls (CTRL) on a pictorial reasoning paradigm under three conditions: V, requiring visuospatial processing; S, requiring language (i.e., semantic) processing; and V+S, a hybrid condition in which language use could facilitate visuospatial transformations. Activated areas in the brain were chosen as endpoints for probabilistic diffusion tractography to examine tract integrity (FA) within the structural network underlying the activation patterns. The two groups showed similar networks, with linguistic processing activating inferior frontal, superior and middle temporal, ventral visual, and temporo-parietal areas, whereas visuospatial processing activated occipital and inferior parietal cortices. However, HFA appeared to activate occipito-parietal and ventral temporal areas, whereas CTRL relied more on frontal and temporal language regions. The increased reliance on visuospatial abilities in HFA was supported by intact connections between the inferior parietal and the ventral temporal ROIs. In contrast, the inferior frontal region showed reduced connectivity to ventral temporal and middle temporal areas in this group, reflecting impaired activation of frontal language areas in autism. The HFA groups engagement of posterior brain regions along with its weak connections to frontal language areas suggest support for a reliance on visual mediation in autism, even in tasks of higher cognition.

Head movements of children in MEG: quantification, effects on source estimation, and compensation.

Head movements during magnetoencephalography (MEG) recordings may lead to inaccurate localization of brain activity. This can be particularly problematic for studies with children. We quantified head movements in 8- to 12-year-old children performing a cognitive task and examined how the movements affected source estimation. Each child was presented auditory word stimuli in five 4-min runs. The mean change in the MEG sensor locations during the experiment ranged from 3 to 26mm across subjects. The variation in the head position was largest in the up-down direction. The mean localization error in equivalent current dipole (ECD) simulations was 12mm for runs with the most head movement, with the frontal cortex appearing to be most prone to errors due to head movements. In addition, we examined the effect of head movements on two types of source estimates, ECDs and minimum-norm estimates (MNE), for an auditory evoked response. Application of a recently introduced signal space separation (SSS) method to compensate for the head movements was found to increase the goodness-of-fit of the ECDs, reduce the spatial confidence intervals of the ECDs, and enhance the peak amplitude in the MNE. These results are indicative of the SSS method being able to compensate for the spatial smoothing of the signals caused by head movements. Overall, the results suggest that MEG source estimates are relatively robust against head movements in children, and that confounds due to head movements can be successfully dealt with in MEG studies of developmental cognition.

Neural Mechanisms in Dyslexia

Within the last two decades, evidence from many laboratories has converged to indicate the cognitive basis for dyslexia: Dyslexia is a disorder within the language system and, more specifically, within a particular subcomponent of that system, phonological processing. Converging evidence from a number of laboratories using functional brain imaging indicates that there is a disruption of left-hemisphere posterior neural systems in child and adult dyslexic readers when they perform reading tasks. The discovery of a disruption in the neural systems serving reading has significant implications for the acceptance of dyslexia as a valid disorder—a necessary condition for its identification and treatment. Brain-imaging findings provide, for the first time, convincing, irrefutable evidence that what has been considered a hidden disability is “real,” and these findings have practical implications for the provision of accommodations, a critical component of management for older children and young adults attending postsecondary and graduate programs. The utilization of advances in neuroscience to inform educational policy and practices provides an exciting example of translational science being used for the public good.

Speech Perception Deficits in Poor Readers A Reply to Denenberg's Critique

We reply to Denenbergs (1999) recent critique of our work (Mody, Studdert-Kennedy, & Brady, 1997). Denenberg mounted two main lines of criticism, one concerning characteristics of the population sampled for the experimental group, and the other a statistical critique, concerning (a) violation of parametric assumptions for use of the F distribution and (b) our supposed acceptance of the null hypothesis of no differences between experimental and control groups. We show that the first criticism stemmed from a misunderstanding of the experimental hypothesis and that the second can be answered by both parametric and nonparametric comparisons across conditions within the experimental group, without reference to the control group. Thus, our original conclusion stands: The difficulty with rapid /ba/-/da/ discrimination that some children with reading impairment may experience does not stem from difficulty in discriminating the rapid spectral transitions at stop-vowel syllable onsets.

Gradient Effects of Fundamental Frequency on Stop Consonant Voicing Judgments

The post-stop-release rise or fall of fundamental frequency (F0) is known to affect voicing judgments of syllables with ambiguous voice onset times (VOTs). In 1986, Silverman claimed that the critical factor was not direction of F0 change but rather its direction relative to the intonational contour. He further claimed that only F0s that start above and fall to the contour have an effect proportional to the size of the frequency change; F0s that rise to the contour by different amounts were claimed to be equivalent. In our first experiment, we examined the effect on voicing judgments of five onset F0s preceding a single, flat contour. Only falling F0s were differentiated in the first set of judgments, but after increased exposure to the syllables, even F0s below the contour differentially affected the voicing judgment. In a second experiment, the contour of the final part of the syllable was flat, rising or falling. F0 contour affected the judgments, as did onset F0s, but the two factors did not interact, indicating that the onset values were not being judged by reference to the contours. However, the contour which was predicted to result in more voiceless judgments also ended at a higher F0 in the vowel, and another effect of voicing is that the F0 is higher throughout the vowel after voiceless stops. In a third experiment, F0 contours were created to contrast contour and mean F0. The effect of the F0 during the vocalic segment appeared to be attributable to the average F0 rather than the contour. In all three experiments, the F0 onset values contributed to the voicing judgment whether they were above or below the putative intonation contour. The contribution of the lower F0s, while significant, was not as great as that of the higher F0s, which argues for a noncategorical contribution of intonation.

Sex Differences in the Default Mode Network with Regard to Autism Spectrum Traits: A Resting State fMRI Study

Autism spectrum traits exist on a continuum and are more common in males than in females, but the basis for this sex difference is unclear. To this end, the present study draws on the extreme male brain theory, investigating the relationship between sex difference and the default mode network (DMN), both known to be associated with autism spectrum traits. Resting-state functional magnetic resonance imaging (MRI) was carried out in 42 females (mean age ± standard deviation, 22.4 ± 4.2 years) and 43 males (mean age ± standard deviation, 23.8 ± 3.9 years) with typical development. Using a combination of different analyses (viz., independent component analysis (ICA), fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and seed-based analyses), we examined sex differences in the DMN and the relationship to autism spectrum traits as measured by autism-spectrum quotient (AQ) scores. We found significant differences between female and male subjects in DMN brain regions, with seed-based analysis revealing a significant negative correlation between default-mode resting state functional connectivity of the anterior medial prefrontal cortex seed (aMPFC) and AQ scores in males. However, there were no relationships between DMN sex differences and autism spectrum traits in females. Our findings may provide important insight into the skewed balance of functional connectivity in males compared to females that could serve as a potential biomarker of the degree of autism spectrum traits in line with the extreme male brain theory.

Gamma phase locking modulated by phonological contrast during auditory comprehension in reading disability.

Children with specific reading impairment may have subtle deficits in speech perception related to difficulties in phonological processing. The aim of this study was to examine brain oscillatory activity related to phonological processing in the context of auditory sentence comprehension using magnetoencephalography to better understand these deficits. Good and poor readers, 16–18 years of age, were tested on speech perception of sentence-terminal incongruent words that were phonologically manipulated to be similar or dissimilar to corresponding congruent target words. Functional coupling between regions was measured using phase-locking values (PLVs). Gamma-band (30–45 Hz) PLV between auditory cortex and superior temporal sulcus in the right hemisphere was differentially modulated in the two groups by the degree of phonological contrast between the congruent and the incongruent target words in the latency range associated with semantic processing. Specifically, the PLV was larger in the phonologically similar than in the phonologically dissimilar condition in the good readers. This pattern was reversed in the poor readers, whose lower PLV in the phonologically similar condition may be indicative of the impaired phonological coding abilities of the group, and consequent vulnerability under perceptually demanding conditions. Overall, the results support the role of gamma oscillations in spoken language processing.

Auditory word perception in sentence context in reading-disabled children

Reading difficulties seem to be related to a phonological deficit that has its origin in poor speech perception. As such, disabled readers may use contextual cues to compensate for their weak speech perception abilities. We compared good and poor readers, 7–13 years old, on auditory perception of words varying in phonological contrast, in congruent versus incongruent sentence contexts. Both groups did worse in the phonologically similar than in the phonologically dissimilar incongruent condition. Magnetoencephalography revealed differential activation between the groups as a function of phonological contrast in left superior temporal gyrus between 200 and 300 ms, suggesting that poor readers may have processed phonologically similar incongruent stimuli as congruent. The results are consistent with a phonological account of reading disability.

Neural correlates of diacritics in Arabic: An fMRI study

Abstract Though diacritics are a central feature of Arabic reading, their cognitive and neural effects remain less well understood. The present study used functional magnetic resonance imaging (fMRI) to investigate differences between brain activation patterns associated with real words with versus without diacritics in adult Arabic readers using a lexical decision task. We found no significant difference in accuracy between real words with and without diacritics. However, real words with no diacritics yielded shorter response times and stronger activation in the hippocampus and middle temporal gyrus, possibly reflecting a search among multiple lexical entries that may be associated with these words. In contrast, real words with diacritics yielded longer response times and activated the insula and inferior frontal areas, suggesting an engagement of phonological and semantic processes in recognizing words with diacritics. Taken together, the results support a linguistic role for diacritics in isolated word recognition even in experienced Arabic readers.