Mariaenrica Tinè
University of Padua
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Featured researches published by Mariaenrica Tinè.
Annals of the American Thoracic Society | 2016
Manuel G. Cosio; Erica Bazzan; Chiara Rigobello; Mariaenrica Tinè; Graziella Turato; Simonetta Baraldo; Marina Saetta
From the discovery that alpha-1 antitrypsin (AAT) was an effective inhibitor of neutrophil elastase originated the classic paradigm of protease/antiprotease imbalance, linking lung destruction to the unopposed effect of proteases in patients with the deficiency. Notwithstanding its importance as an antiprotease, it has become evident that alpha-1 antitrypsin has important antiinflammatory and immune-regulatory activities, which may be critically involved in lung destruction. We review here recent evidence showing that, indeed, an important adaptive immune reaction is present in lungs with AAT deficiency, similar to the one seen in severe chronic obstructive pulmonary disease with normal AAT. On the basis of recent evidence from epidemiological, clinical, and pathogenetic studies, it is likely time to move on from the original protease/antiprotease hypothesis for the production of emphysema toward a more complex paradigm, involving the antiinflammatory and immune modulating functions of AAT.
American Journal of Respiratory Cell and Molecular Biology | 2018
Matteo Bonato; Erica Bazzan; Deborah Snijders; Mariaenrica Tinè; Davide Biondini; Graziella Turato; Elisabetta Balestro; Alberto Papi; Manuel G. Cosio; Angelo Barbato; Simonetta Baraldo; Marina Saetta
Abstract Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that might predict the future development of asthma in children. Eighty children (mean age 3.8 ± 1 yr) who underwent a clinically indicated bronchoscopy were followed prospectively for a median of 5 years. At baseline, clinical characteristics with a particular focus on wheezing and its presentation (episodic or multitrigger) were collected, and structural and inflammatory changes were quantified in bronchial biopsies. Follow‐up data were available for 74 of the 80 children. Children who presented with multitrigger wheeze were more likely to have asthma at follow‐up than those with episodic wheeze (P = 0.04) or without wheeze (P < 0.0001). Children with asthma also had lower birth weights (P = 0.02), a lower prevalence of breastfeeding (P = 0.02), and a trend for increased IgE (P = 0.07) at baseline than those with no asthma. Basement membrane thickness and airway eosinophils at baseline were increased in children who developed asthma at follow‐up (P = 0.001 and P = 0.026, respectively). Multivariate analysis showed that among all clinical and pathological factors, multitrigger wheezing, basement membrane thickening, and reduced birth weight were predictive of future asthma development. We conclude that multitrigger wheeze and reduced birth weight are clinical predictors of asthma development. Basement membrane thickening in early childhood is closely associated with asthma development, highlighting the importance of airway remodeling in early life as a risk factor for future asthma.
Chest | 2018
Erica Bazzan; Mariaenrica Tinè; Davide Biondini; Riccardo Benetti; Simonetta Baraldo; Graziella Turato; S. Fagiuoli; Aurelio Sonzogni; Chiara Rigobello; Federico Rea; Fiorella Calabrese; Maria P. Foschino-Barbaro; Elena Miranda; David A. Lomas; Marina Saetta; Manuel G. Cosio
BACKGROUND: The deficiency of &agr;1‐antitrypsin (AAT) is secondary to misfolding and polymerization of the abnormal Z‐AAT in liver cells and is associated with lung emphysema. Alveolar macrophages (AMs) produce AAT; however, it is not known whether Z‐AAT can polymerize in AMs, further decreasing lung AAT and promoting lung inflammation. Our intention was to investigate whether AAT polymerizes in human AMs and to study the possible relation between polymerization and degree of lung inflammation. METHODS: Immunohistochemical analysis with 2C1 monoclonal antibody specific for polymerized AAT was performed in sections of the following: nine lungs from individuals with AAT deficiency (AATD) and severe COPD; 35 smokers with normal AAT levels, of whom 24 had severe COPD and 11 did not have COPD; and 13 nonsmokers. AMs positive for AAT polymers were counted and expressed as the percentage of total AMs in the lungs. RESULTS: AAT polymerization was detected in 27% (4%‐67%) of AMs from individuals with AATD but also in AMs from smokers with normal AAT with (24% [0%‐70%]) and without (24% [0%‐60%]) COPD, but not in AMs from nonsmokers (0% [0%‐1.5%]) (P < .0001). The percentage of AMs with polymerized AAT correlated with pack‐years smoked (r = 0.53, P = .0001), FEV1/FVC (r = −0.41, P = .005), small airways disease (r = 0.44, P = .004), and number of CD8+ T cells and neutrophils in alveolar walls (r = 0.51, P = .002; r = 0.31, P = .05, respectively). CONCLUSIONS: Polymerization of AAT in alveolar macrophages occurs in the lungs of individuals with AATD but also in smokers with normal AAT levels with or without COPD. Our findings highlight the similarities in the pathophysiology of COPD in individuals with and without AATD, adding a potentially important step to the mechanism of COPD.
American Journal of Respiratory and Critical Care Medicine | 2017
Graziella Turato; Umberto Semenzato; Erica Bazzan; Davide Biondini; Mariaenrica Tinè; Nerea Torrecilla; Marta Forner; Jose M. Marin; Manuel G. Cosio; Marina Saetta
Respiratory Research | 2017
Erica Bazzan; Graziella Turato; Mariaenrica Tinè; Claudia Radu; Elisabetta Balestro; Chiara Rigobello; Davide Biondini; Marco Schiavon; Francesca Lunardi; Simonetta Baraldo; Federico Rea; Paolo Simioni; Fiorella Calabrese; Marina Saetta; Manuel G. Cosio
European Respiratory Journal | 2014
Elena Mutti; Simonetta Baraldo; Erica Bazzan; Graziella Turato; Deborah Snijders; Marco Damin; Riccardo Cazzuffi; Marco Poletti Poletti; Mariaenrica Tinè; Manuel G. Cosio; Angelo Barbato; Marina Saetta
European Respiratory Journal | 2017
Graziella Turato; Umberto Semenzato; Maria Martinez; Davide Biondini; Mariaenrica Tinè; Jose M. Marin; Marina Saetta; Manuel G. Cosio
European Respiratory Journal | 2017
Graziella Turato; Umberto Semenzato; Nerea Torrecilla; Erica Bazzan; Davide Biondini; Mariaenrica Tinè; Paula Gambó; Jose M. Marin; Manuel Cosio; Marina Saetta
European Respiratory Journal | 2017
Erica Bazzan; Mariaenrica Tinè; Riccardo Benetti; Elena Miranda; Davide Biondini; Graziella Turato; Manuela Sgambato; Federico Rea; Fiorella Calabrese; Simonetta Baraldo; David A. Lomas; Manuel G. Cosio; Marina Saetta; Chiara Rigobello
European Respiratory Journal | 2016
Simonetta Baraldo; Matteo Bonato; Deborah Snijders; Erica Bazzan; Graziella Turato; Chiara Rigobello; Brunilda Marku; Mariaenrica Tinè; Kim Lokar Oliani; Manuel Cosio; Angelo Barbato; Alberto Papi; Marina Saetta