Mariano Castillo

Mono and sesquiterpenoids from Satureja gilliesii

Abstract Two new isomeric monoterpene peroxides along with (+)-T-cadinol and (−)-cadin-4-en-1-o1 were isolated from the leaves of Satureja gilliesii (Lamiaceae). Significant toxicity toward Artemia salina (brine shrimp bioassay) was observed for the cadinane sesquiterpenoids.

Alkaloids of Lycopodium magellanicum

Abstract Six alkaloids have been isolated from Lycopodium magellanicum . These include the known alkaloids lycopodine, acetyldihydrolycopodine, lycodine, N -methyllycodine, acetylfawcettine and a new alkaloid, 5-dehydro-magellanine. The chemical correlation of magellanine and paniculatine and the establishment of their absolute configuration are described.

Tropane alkaloids from Schizanthus hookeri

Abstract Tropine, a pair of diastereoisomeric hygrolines and two new tropane alkaloids; 3α-senecioyloxytropan-6β-ol and 6β-angeloyloxytropan-3α-ol, were isolated from roots of Schizanthus hookeri .

Tropane alkaloids from Schizanthus grahamii

Abstract Three new tropanol dimers of mesaconic and itaconic acids and 3α-senecioyloxytropane, together with other known alkaloids, were isolated from Schizanthus grahamii . The structures of the new compounds were established by spectroscopic and chemical transformations including 2-D long-range 13 C- 1 H correlations.

Neo-clerodane diterpenoids and other constituents from Baccharis species

Abstract A new neo -clerodane dilactone, desoxyarticulin, and dihydrotucumanoic acid, together with other known compounds, were isolated from Baccharis pedicellata and Baccharis marginalis . The structures of the new compounds were elucidated by spectroscopic methods.

Neo-clerodane diterpenoids from Baccharis incarum

Abstract A new neo-clerodane diterpenoid was isolated from the aerial parts of Baccharis incarum together with the previously known diterpenoids bacchalineol and barticulidiol.

Angeloyl, tigloyl and senecioyloxytropane alkaloids from Schizanthus hookerii

Abstract 6β-Angeloyloxytropan-3α-ol, 3α-senecioyloxytropan-6β-ol and 6β-tigloyloxytropan-3α-ol, tropine and two diasteromeric hygrolines were isolated from Schizanthus hookerii .

Rearranged isopimarenes and other diterpenoids from Satureja gilliesii

Abstract Seven new diterpenoids, a labdane, three isopimarenes and three rearranged isopimarenes, have been isolated from the flowering tops of Satureja gilliesii . Their structures are based on their spectroscopic properties and, in the case of one compound, confirmed by crystal structure analysis. A new 18(4→3)abeoisopimarene nucleus is proposed for three of the compounds. The compounds were tested for toxicity (brine shrimp bioassay) and antifeedant activity ( Spodoptera littoralis , disc choice). The results of this study suggest the existence of chemical races of S. gilliesii .

Neo-clerodane diterpenoids from Baccharis rhomboidalis

Abstract Three new neo-clerodane diterpenoids were isolated together with other known clerodanes from Baccharis rhomboidalis . Their structures were established by spectroscopic methods.

(25R)-isonuatigenin, an unusual steroidal sapogenin from Vestia lycioides

Abstract (25 R )-Isonuatigenin, a 5 -spirosten-3β,25-diol, was isolated from aerial parts of Vestia lycioides . Its structure was elucidated mainly by 1 H NMR and 13 C NMR spectroscopy. A mixture of (25 R )-nuatigenin and (25 S )-isonuatigenin was also characterized. This is the first report on the natural occurrence of the two (25 R )-isomers.