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Featured researches published by Mariapina Cerulo.


Seminars in Pediatric Surgery | 2016

Current concepts in the management of inguinal hernia and hydrocele in pediatric patients in laparoscopic era

Ciro Esposito; Maria Escolino; Francesco Turrà; Agnese Roberti; Mariapina Cerulo; Alessandra Farina; Simona Caiazzo; Giuseppe Cortese; Giuseppe Servillo; Alessandro Settimi

The surgical repair of inguinal hernia and hydrocele is one of the most common operations performed in pediatric surgery practice. This article reviews current concepts in the management of inguinal hernia and hydrocele based on the recent literature and the authors׳ experience. We describe the principles of clinical assessment and anesthetic management of children undergoing repair of inguinal hernia, underlining the differences between an inguinal approach and minimally invasive surgery (MIS). Other points discussed include the current management of particular aspects of these pathologies such as bilateral hernias; contralateral patency of the peritoneal processus vaginalis; hernias in premature infants; direct, femoral, and other rare hernias; and the management of incarcerated or recurrent hernias. In addition, the authors discuss the role of laparoscopy in the surgical treatment of an inguinal hernia and hydrocele, emphasizing that the current use of MIS in pediatric patients has completely changed the management of pediatric inguinal hernias.


Journal of Laparoendoscopic & Advanced Surgical Techniques | 2015

Retroperitoneoscopic Heminephrectomy in Duplex Kidney in Infants and Children: Results of a Multicentric Survey

Ciro Esposito; Go Miyano; Paolo Caione; Maria Escolino; Fabio Chiarenza; Giovanna Riccipetitoni; Atsuyuki Yamataka; Mariapina Cerulo; Antonio Savanelli; Alessandro Settimi; Jean Stephane Valla

PURPOSE Retroperitoneoscopic partial nephrectomy (RPN) in children is considered a complex technique with limited diffusion among pediatric surgeons and urologists. We aimed to report the outcome of this technique in infants and children with duplex kidney in a 5-year retrospective multicentric international survey. MATERIALS AND METHODS Data on 50 children who underwent RPN (41 upper-pole nephrectomies and 9 lower-pole nephrectomies) were retrospectively collected in this six-institution survey. Median age at surgery was 3.3 years. There were 35 girls and 15 boys. The left side was affected in 28 patients, versus the right side in 22 patients. We assessed intraoperative and postoperative morbidity. Follow-up (median, 2.5 years; range, 12 months-5 years) was based on clinical controls and echo color Doppler renal ultrasound scans. RESULTS Median duration of surgery was 255 minutes. Surgery was always performed with the patient in a lateral position. Special hemostatic devices were used for dissection and parenchymal section in all centers. Three patients from two centers (6%) required conversion to open surgery. We recorded seven complications (six peritoneal perforations, one opening of the remaining calyxes) in the 50 cases. Re-operation rate was 0%. Average length of hospital stay was 4.1 days. CONCLUSIONS Our survey shows that RPN remains a challenging procedure with a long learning curve, performed only in pediatric centers with huge experience in this field. In our survey operative time was longer than 4 hours. The complication rate remains high (7/50, or 14%), with complications classified as Grade II according to the Clavien-Dindo classification. They did not require further surgery, but they were associated with a prolonged hospital stay.


Journal of Pediatric Urology | 2016

Evaluation and outcome of the distal ureteral stump after nephro-ureterectomy in children. A comparison between laparoscopy and retroperitoneoscopy

Maria Escolino; Alessandra Farina; Francesco Turrà; Mariapina Cerulo; Rosanna Esposito; Antonio Savanelli; Alessandro Settimi; Ciro Esposito

BACKGROUND In children with a poorly functioning kidney due to vesicoureteral reflux (VUR) or ureteropelvic junction obstruction, management is by nephrectomy with total or proximal ureterectomy. The complete removal of all the ureter minimizes the risk of future morbidity associated with the distal ureteral stump (DUS), including febrile urinary tract infections (UTIs), lower quadrant pain and hematuria, the so-called ureteral stump syndrome. OBJECTIVE To assess the outcome of the DUS after nephroureterectomy, we analyzed our recent experience of nephrectomy performed via retroperitoneoscopy and via laparoscopy. METHODS The records of 21 consecutive patients (median age 3.5 years, range 1-10 years) who underwent nephroureterectomy via laparoscopy or via retroperitoneoscopy were retrospectively reviewed for symptoms caused by DUS and their management. Nephrectomy was undertaken for a poorly functioning dysplastic (4), scarred from VUR (10) or hydronephrotic (7) kidney. In the laparoscopic group (11 pts), 6 cases required nephrectomy for reflux while 5 patients were operated for hydronephrotic or dysplastic non-functioning kidney. In the retroperitoneoscopic group (10 pts), nephrectomy was performed for reflux in 4 cases versus 6 patients affected by hydronephrotic or dysplastic non-functioning kidney. The patients were evaluated using ultrasound (US) to check DUS length and clinically to evaluate symptoms due to a symptomatic DUS. RESULTS The average length of surgery was 50 min for laparoscopy and 80 min for retroperitoneoscopy. The average of follow-up was 5 years. The length of DUS after laparoscopic nephrectomy was shorter (range 3-7 mm, statistically significant) than the DUS after retroperitoneoscopy (range 2-5 cm) (p < 0.001). Laparoscopic patients were all asymptomatic. Two patients, after retroperitoneoscopic nephrectomy, presented with recurrent UTIs; a voiding cystography revealed a VUR on the residual DUS and a redo surgery was performed in both the patients to remove the DUS (Figure). DISCUSSION Several authors have stated that, in case of subtotal ureterectomy, the incidence of symptomatic DUS after nephrectomy for high-grade vesicoureteric reflux is low. However, in our series, the incidence of symptomatic DUS after nephroureterectomy was not insignificant (2/21, 9.5%). Symptoms related to a refluxing DUS occurred only in patients undergoing retroperitoneoscopic nephroureterectomy, where the DUS was longer than the DUS detected in laparoscopic patients. CONCLUSIONS Considering that laparoscopy permits removal of all the ureter near the bladder dome, in children with non-functioning kidney due to VUR, it is advisable to always perform a laparoscopic rather than a retroperitoneoscopic nephrectomy to prevent problems related to a symptomatic DUS.


Pediatric Health, Medicine and Therapeutics | 2015

Management of gastroesophageal reflux disease in pediatric patients: a literature review

Ciro Esposito; Agnese Roberti; Francesco Turrà; Maria Escolino; Mariapina Cerulo; Alessandro Settimi; Alessandra Farina; Pietro Vecchio; Antonio Di Mezza

Gastroesophageal reflux (GER), defined as the passage of gastric contents into the esophagus, is a physiologic process that occurs throughout the day in healthy infants and children. Gastroesophageal reflux disease (GERD) occurs when gastric contents flow back into the esophagus and produce symptoms. The most common esophageal symptoms are vomiting and regurgitation. Lifestyle changes are the first-line therapy in both GER and GERD; medications are explicitly indicated only for patients with GERD. Surgical therapies are reserved for children with intractable symptoms or who are at risk for life-threatening complications of GERD. The laparoscopic Nissen antireflux procedure is the gold standard for the treatment of this pathology. A literature search on PubMed and Cochrane Database was conducted with regard to the management of GERD in children to provide a view of state-of-the-art treatment of GERD in pediatrics.


Medicine Science and The Law | 2015

Fetal laceration during caesarean section and its medico-legal sequelae

Ciro Esposito; Maria Escolino; Mariano Paternoster; Claudio Buccelli; Vincenzo Graziano; Marianna Falco; Francesca Alicchio; Mariapina Cerulo; Alessandro Settimi; Antonio Savanelli

Fetal laceration is a recognized complication of caesarean delivery. The aim of this study was to investigate the incidence, type, location, risk factors and long-term consequences of accidental fetal incised wounds during caesarean delivery. During a five-year period, we observed 25 cases of fetal lacerations caused by the scalpel during hysterotomy. In 20 of these cases, we observed these lesions as consultants for the Neonatologic Care Unit; the other five cases came under our care after an insurance claim for damages against the gynaecologist. All the infants had a lesion located to the head. In only 5 of the 25 cases the lesion was reported in the operative summary, and only 16 of the 25 mothers had signed an informed consent before surgery. With regard to the 20 cases diagnosed at the Neonatologic Care Unit, the lesion was closed using single stitches in nine cases, and with biological glue in 11 cases. Concerning the five cases that underwent legal proceedings against the gynaecologist, a clinical examination was performed by an expert in Public Health and Social Security in collaboration with a paediatric surgeon to evaluate the degree of biological damage. In all five cases, the result of the legal challenge was monetary compensation for the physical and moral damage caused by the gynaecologists to the patients and their parents. Accidental fetal lesions may occur during caesarean delivery; the incidence is significantly higher during emergency caesarean delivery compared to elective procedures. Patients should sign an informed consent in which they should be informed about the risk of the occurrence of fetal lacerations during caesarean delivery in order to avoid legal complications.


Surgical Endoscopy and Other Interventional Techniques | 2017

Twenty-year experience with laparoscopic inguinal hernia repair in infants and children: considerations and results on 1833 hernia repairs.

Ciro Esposito; Maria Escolino; Giuseppe Cortese; Gianfranco Aprea; Francesco Turrà; Alessandra Farina; Agnese Roberti; Mariapina Cerulo; Alessandro Settimi


Surgical Endoscopy and Other Interventional Techniques | 2017

Technical standardization of laparoscopic repair of Morgagni diaphragmatic hernia in children: results of a multicentric survey on 43 patients

Ciro Esposito; Maria Escolino; François Varlet; Amulya K. Saxena; Sabine Irtan; Paul Philippe; Alessandro Settimi; Mariapina Cerulo; Holger Till; François Becmeur; George Holcomb


Surgical Endoscopy and Other Interventional Techniques | 2016

Twenty-year experience with laparoscopic and retroperitoneoscopic nephrectomy in children: considerations and details of technique

Ciro Esposito; Maria Escolino; Francesco Corcione; Isabela Magdalena Draghici; Antonio Savanelli; Marco Castagnetti; Francesco Turrà; Mariapina Cerulo; Alessandra Farina; Alessandro Settimi


World Journal of Urology | 2016

A comparison between laparoscopic and retroperitoneoscopic approach for partial nephrectomy in children with duplex kidney: a multicentric survey

Ciro Esposito; Maria Escolino; Go Miyano; Paolo Caione; Fabio Chiarenza; Giovanna Riccipetitoni; Atsuyuki Yamataka; Antonio Savanelli; Alessandro Settimi; François Varlet; Dariusz Patkowski; Mariapina Cerulo; Marco Castagnetti; Holger Till; Rosaria Marotta; Angela La Manna; Jean Stephane Valla


Pediatric Surgery International | 2015

European society of pediatric endoscopic surgeons (ESPES) guidelines for training program in pediatric minimally invasive surgery

Ciro Esposito; Maria Escolino; Amulya Saxena; Philippe Montupet; Fabio Chiarenza; Juan De Agustin; Isabela Magdalena Draghici; Mariapina Cerulo; Mario Mendoza Sagaon; Vincenzo Di Benedetto; Piergiorgio Gamba; Alessandro Settimi; Azad S. Najmaldin

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Ciro Esposito

University of Naples Federico II

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Maria Escolino

University of Naples Federico II

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Alessandro Settimi

University of Naples Federico II

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Francesco Turrà

University of Naples Federico II

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Alessandra Farina

University of Naples Federico II

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Agnese Roberti

University of Naples Federico II

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Antonio Savanelli

University of Naples Federico II

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Giuseppe Cortese

University of Naples Federico II

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