Maribel Tirado-Gomez

Longitudinal social cognitive influences on physical activity and sedentary time in Hispanic breast cancer survivors.

This study evaluated the effect of two home‐based exercise interventions (one culturally adapted and one standard) on changes in social cognitive theory (SCT) variables, physical activity (PA), and sedentary time (ST), and determined the association between changes in SCT variables and changes in PA and ST in Hispanic breast cancer survivors.

Mexican-American and Puerto Rican Breast Cancer Survivors’ Perspectives on Exercise: Similarities and Differences

Qualitative data was collected from Mexican-American (MA) and Puerto Rican (PR) breast cancer survivors to gain their perspectives on the relevant issues surrounding breast cancer survivorship and exercise. Six focus groups, a total of 31 participants were convened (three in Puerto Rico and three in Texas). Responses were analyzed and compared between the MA and PR groups. Follow-up sessions were conducted at the sites to review the initial results and to validate a culturally adapted exercise intervention trial. A total of 900 responses were catalogued into 27 codes. Both groups had similar descriptions of exercise and barriers to exercise. Both groups expressed lack of information regarding their exercise capabilities. The groups differed in their responses to perceived safety in their community and how to deliver a culturally adapted exercise intervention in their community. We found important cultural differences and similarities in relevant factors of exercise and breast cancer survivorship.

Abstract B32: Serum adipokines and inflammatory markers in Hispanic breast cancer survivors

Objective: Physical activity can improve breast cancer survivor9s physical and emotional well-being while reducing their risk of other chronic diseases and breast cancer recurrence. Although the exact biological mechanisms responsible for the decrease in breast cancer recurrence in those patients that exercise are not known, it is postulated that physical activity modulates serum markers of adiposity and inflammation. The purpose of this study is to evaluate the change in adipokines and inflammatory markers in a group of Puerto Rican breast cancer survivors who participated in a 16-week exercise intervention. Methods: The study recruited 38 women breast cancer survivors who were at least 3 months post treatment (surgery, chemotherapy or radiotherapy) and were not meeting current recommended physical activity guidelines according to ACSM. The study randomly assigned participants to a control group (no exercise; n=11), an intervention group that received culturally adapted written exercise materials (n=13), and an exercise control group (n=14) who received an exercise intervention that was not culturally tailored. Demographic and anthropometric data was obtained at baseline and at the end of the intervention. A fasting peripheral blood sample was obtained at baseline and at the end of the 16-week intervention. The serum was isolated by means of gradient centrifugation and stored at -80°C. Serum levels of Adiponectin, Leptin, IL-6 and C-reactive protein were measured by ELISA. One-way repeated measures ANOVA or Kruskall-Wallis test was utilized to compare differences among baseline and 16-weeks values. Statistical analyses were performed using Stata for Windows release 12.0 (Stata Corporation, College Station, Texas). Results: Thirty-eight patients completed both baseline and 16 week assessments (11 controls; 14 in standard intervention, 13 in culturally tailored intervention. The mean age was 58 years (range 27-80). Most of the participants were overweight/obese (89%) with a mean BMI of 32.7 (21.3-51.6). Mean Leptin serum levels were 31.6 ng/mL (5.1-63.3 ng/mL ng/mL). Mean serum C-reactive protein levels were 4.15 ug/mL (0.5-8.7 ug/mL). Mean serum Adiponectin levels were 30.6 ng/mL (2.4-105.3 ng/mL). Mean serum IL-6 levels were 2.42 (0.7-10.2 pg/mL). At the end of the 16 week period, no differences (p > 0.05) were found in BMI, or in the levels of the biological markers evaluated, leptin, adiponectin, IL-6 and C-reactive protein, when comparing to baseline neither in the control nor the interventions groups. Conclusion: There were no significant differences in BMI, adipokines and inflammatory biomarkers as a result of this intervention. However, this preliminary data reveals a population with increased BMI where exercise and nutritional interventions are needed. It must be noted that this is a pilot study were the numbers of participants is small and the follow-up period is short, thus a higher number of participants is needed to further define the efficacy of this intervention. Citation Format: Maribel Tirado-Gomez, Cristina Palacios, Alexis Ortiz, Daniel C. Hughes, Velda Gonzalez-Mercado, Liliana Vallejo, Jose Lozada, Karen Basen-Engquist. Serum adipokines and inflammatory markers in Hispanic breast cancer survivors. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr B32.

Results of Upfront Therapy for Marginal Zone Lymphoma

Micro‐Abstract Marginal zone lymphomas are usually managed with either radiation therapy or watch and wait except for Helicobacter pylori positive gastric MALT lymphomas. We hereby describe the successful application of systemic upfront therapy for patients with advanced as as well as recurrent disease. Background: Marginal zone lymphomas (MZLs) are indolent disorders composed of 3 subtypes: extranodal marginal zone lymphoma (MALT), splenic marginal zone lymphoma (SMZL), and nodal marginal zone lymphoma (NMZL). Early‐stage MALT is treated with radiotherapy or antibiotics, and advanced MALT and NMZL are managed with either watch and wait or chemotherapy. SMZLs are treated with splenectomy or rituximab. However, because these approaches have failed to cure patients with SMZL and NMZL, we have systematically used upfront chemotherapy for them, as well as for advanced MALT. We report the outcomes of this approach. Patients and Methods: A total of 44 patients with MZL were identified from our database and divided into 2 groups. Group 1 (22 with early‐stage MALT) patients received either radiotherapy (n = 17) or antibiotics with or without surgery (n = 5). Group 2 included 9 patients with advanced MALT, 9 with SMZL, and 4 with NMZL. Group 2 was treated with FND‐R (fludarabine 25 mg/m2 on days 1 to 3, mitoxantrone 10 mg/m2 on day 1, dexamethasone 20 mg on days 1 to 5, and rituximab 375 mg/m2 on day 1; n = 14) or CHOP‐R (cyclophosphamide 750 mg/m2 on day 1, doxorubicin 50 mg/m2 on day 1, vincristine 2 mg intravenous push on day 1, prednisone 100 mg/m2 orally on days 1 to 5, rituximab 375 mg/m2 on day 1; n = 8), followed by maintenance rituximab for 70%. Results: All patients achieved complete remission, and only 2 patients in group 1 had developed a relapse at 70 and 75 months. Both relapses were stage I MALT that had initially been treated with radiotherapy. Both were salvaged with FND‐R and remained free of disease at 27 and 39 months after the relapse. At 10 years, the failure‐free survival for the 44 patients was 80% and the overall survival was 100%. None of the patients in group 2 developed a relapse. The long‐term toxicities have been acceptable. Conclusions: The excellent responses using upfront chemotherapy for MZL suggests that this disorder is curable. Our results should be confirmed in a prospective trial.

Abstract B69: Mediated effects of social cognitive theory variables on physical activity in Hispanic breast cancer survivors

Purpose: The vast majority of long-term cancer survivors are insufficiently active, and breast cancer survivors are more likely to report being physically inactive and sedentary than prostate or colorectal cancer survivors. Social cognitive theory (SCT) has been used to understand physical activity adoption and maintenance in the general adult population and among breast cancer survivors, but no study to date has explored SCT influences on physical activity exclusively among Hispanic cancer survivors, who are at greater risk of not meeting leisure-time physical activity guidelines and disproportionately suffer from comorbidities, such as cardiovascular disease and diabetes. Thus, the purpose of this study was to determine the effect of a culturally-tailored exercise intervention on physical activity and sedentary behavior in Hispanic breast cancer survivors and to determine whether intervention effects were mediated by changes in SCT variables, including exercise self-efficacy, barriers self-efficacy, social modeling and social support. Method: Project VIVA! was a 16-week randomized controlled trial to test the effectiveness and feasibility of a culturally tailored exercise intervention for Mexican American and Puerto Rican breast cancer survivors in Houston, Texas and San Juan, Puerto Rico. Eligible women (N=93) who self-identified as Mexican American residing in Houston, TX or Puerto-Rican residing in San Juan, PR were randomized to a 16-week culturally-tailored (n=30) or standard (n=31) exercise intervention or a wait-list control (n=32) group. Women completed questionnaires on social cognitive influences, physical activity and sedentary behavior and completed a 7-day accelerometer protocol at baseline and post-intervention. Paired sample t-tests were used to assess changes in physical activity, sedentary behavior, and SCT variables over time across groups, and repeated measures analyses were used to assess changes over time by group. Mediation analyses were used to determine whether intervention effects on physical activity and sedentary behavior were mediated by changes in exercise self-efficacy, barriers self-efficacy, social modeling and social support after controlling for age and education. Results: On average, participants were middle-aged (M age=55.5 years, SD=9.9) and most (52.1%) had completed some college or more. At baseline, women reported doing roughly 11.6 minutes of physical activity and walking per day and were sedentary over 6 hours per day. Across groups, women reported increases in vigorous (t=2.7, p=.008), moderate (t=2.6, p=.011) and total (t=2.7, p=.008) physical activity and exercise self-efficacy (t=3.2, p=.002) from baseline to post-intervention. There were no significant differences in changes in physical activity or SCT variables over time by group. Although the intervention did not have a direct effect on physical activity or sedentary behavior, it had an indirect effect on sedentary behavior. Increases in social modeling significantly mediated the association between intervention group assignment and decreases in sedentary behavior (Indirect effect=4.5, 95% CI: 0.4, 12.4) among Hispanic breast cancer survivors, controlling for age and education. Conclusions: Results suggest that Hispanic survivors may benefit the most from exercise interventions that focus on increasing social norms for physical activity and social modeling from friends and family members. Future interventions should include friends and family members of Hispanic breast cancer survivors to support them to be active and less sedentary and to be physically active with them. Further research is needed to explore additional mediators of change in physical activity and sedentary behavior in Hispanic breast cancer survivors in an effort to reduce health disparities and decrease risk of cancer recurrence and comorbidities. Citation Format: Scherezade K. Mama, Lorna H. McNeill, Alexis Ortiz, Maribel Tirado-Gomez, Cristina Palacios, Daniel C. Hughes, Karen Basen-Engquist. Mediated effects of social cognitive theory variables on physical activity in Hispanic breast cancer survivors. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr B69.

Abstract B29: Differences in physical fitness, disability, and health-related quality of life between physical active and sedentary Hispanic breast cancer survivors

Background: Breast cancer remains the leading cause of cancer mortality among Latina women in the US. Physical activity (PA) and exercise have been shown to reduce morbidity and mortality from cardiometabolic diseases and cancer while improving individual fitness; disability and health related quality of life (HRQoL). However, Latinas, particularly those who speak only Spanish, have not been included in studies in sufficient numbers to identify factors to promote their participation in cancer prevention interventions. Purpose: To compare physical fitness, disability, and HRQoL between physically active and sedentary Hispanic breast cancer survivors. Methods: A total of 94 women (Age: 55.4 ± 9.9; BMI: 29.87 ± 5.62; ) from the Puerto Rico Comprehensive Cancer Center and MD Anderson Cancer Center in Houston, TX participating in Project VIVA! were recruited for this study. The VIVA! Program is a 16-week exercise intervention emphasizing in the minimum guidelines from The American College of Sports Medicine targeting aerobic endurance, muscular strength, balance, and muscle endurance. Participants visited the clinic for fitness testing and assessment of physical activity (PA), disability, and HRQoL through a battery of self-administered questionnaires previous to starting the intervention. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) in the preferred language of the participant; English or Spanish. The physical fitness assessment included: anthropometrics (BMI & waist to hip ratio) measures, adiposity (% body fat) by skinfolds measurement, six-minute walk test (6MWT), lumbar and isquiotibial flexibility by sit-and-reach, grip strength by hand dynamometry, lower extremity endurance testing by sit-to-stand in 30 seconds, upper extremity, low back, and leg strength by Jackson strength testing protocol, shoulder range of motion (ROM) with inclinometer, and balance testing by a functional reach test. Upper and lower extremity function, joint motion and disability were assessed by The Disabilities of the Arm, Shoulder and Hand Score (QuickDASH) and The Western Ontario McMaster University Osteoarthritis Index (WOMAC), respectively. HRQoL was measured by the short version of the QOL (SF-36) questionnaire. For physical activity analyses, sample was divided into two groups based on results from the IPAQ; those with less than 150 min/wk (n = 58) and those exceeding 150 min/wk (n = 36). For analyses of sedentary time, sample was also divided into two groups based on the IPAQ; those spending less than 180 min/day in sitting (n = 46) and those spending greater than 180 mins/day sitting (n = 45). Groups were compared for all variables using analysis of variance (ANOVA). Results: ANOVA for physical activity revealed that those participants engaging in more than 150 min/wk of PA have better 6MWT (p = 0.04) and 30-second sit-to-stand ( p = 0.027) results demonstrating greater cardiorespiratory fitness and muscular endurance, respectively. Those participants spending less than 180 mins/day sitting exhibited better mental component scores in the SF-36 than those spending more time sitting (p = 0.012). Conclusion: It appears that meeting or exceeding the minimum recommended amount of PA and decreasing time spent in sedentary activities have positive physical fitness and HRQoL outcomes in Hispanic women breast cancer survivors. Even though the relationship between PA and sedentary behaviors with measures of physical fitness, disability, and HRQoL are difficult to establish, it is sound for clinicians to start considering PA as a preventive and rehabilitative strategy to improve breast cancer survivors HRQoL. Funding Sources: This project was partially supported by the Center for Energy Balance in Cancer Prevention and Survivorship, Duncan Family Institute, and by the following NIH awards: U54 CA 96297; P30 CA016672; R25T CA057730; and K01 CA 134550. Citation Format: Alexis Ortiz, Maribel Tirado-Gomez, Daniel C. Hughes, Velda Gonzalez, Karen Basen-Engquist. Differences in physical fitness, disability, and health-related quality of life between physical active and sedentary Hispanic breast cancer survivors. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr B29.

Abstract 5230: Circulating miRNA in acute myeloid leukemia: A pilot study

Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Introduction: Acute myeloid leukemia (AML) is within the top 10 cancers in USA. AML Cytogenetic classification currently guides AML treatment selection strategies based on risk-adapted treatment. However, AML has proven to be a heterogeneous disease and in up to 45% of patients, cytogenetic classification fails to predict their clinical outcome and thus fails to guide further therapy. micro-RNA (miRNA) are regulators of hematopoiesis and their expression is related to gene expression modulations. miRNAs can be detected in the blood stream. Thus we intend to evaluate the value of miRNAs as prognostic biomarkers in AML. Methods: Using a retrospective case-control (age-gender match) study design, plasma miRMA was isolated from 10 samples (5 control cases and 5 AML cases). miRNA was isolated from plasma sample using miRNeasy kit. Bio-analyzer was used for determine the miRNA integrity and quality. The miRNA expression level for selected miRNa based on publish data associating them with functions related to hematopoiesis (myeloid), AML and cancer using miScript miRNA PCR Array (Qiagen). Results: A total of 10 samples were analyzed (5 cases/ 5 controls). Gender distribution was 80% female and 20% males, mean age was 59 (range 32 to 66). Cytogenetic risk classification distribution was 40% low risk, 40% high risk and 20% intermediate risk. Down expression of miRNA levels in AML participants compared to controls was found for miR101-3p, miR106b-5p, miR142-3p, miR142-5p, miR-145-5p, miR-148a-3p, miR15a-5p, miR-16-5p, miR199a-5p (all p 0.071). Over expression of miRNA levels in AML participants compared to controls was found for miR100-5p, miR-155-5p, miR34a-5p, miR-182-5p, miR-181b-5p, miR-181a-5p, miR-221-3p, (all p>0.071). Conclusions: We were able to identify statistically significant differences in plasma miRNA expressions levels between AML and control participants. Especially when analyzing miRNA previously associated with hematopoiesis and cancer development like miR-223-3p (myeloid development), miR-101-3p (tumor suppressor), miR-145-5p (anti-oncomiR), miR-155-5p (oncomiR), among others. Our preliminary data analysis is consistent with AML related published data and contrast with others but, most importantly, its analysis results are been consistent with known miRNA, AML and cancer published pathways. Further AML and control subjects recruitment is ongoing in order to provide an increased sample and further confirmation of this preliminary findings. Note: This abstract was not presented at the meeting. Citation Format: Rafael A. Quintana-Ortiz, Sharon Fonseca-Williams, Hector Perez-Cantalapiedra, Mercedes Lacourt-Ventura, Cristina Munoz-Masso, Raul D. Bernabe-Dones, Maribel Tirado-Gomez. Circulating miRNA in acute myeloid leukemia: A pilot study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5230. doi:10.1158/1538-7445.AM2014-5230

Abstract 4783: Expression of genes panel related to WNT- signaling in colorectal cancer Human Papillomavirus-positive colorectal cancer.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC The Wnt signaling pathway is conserved in various species and plays significant roles in development, cellular proliferation and differentiation. WNT signaling comprises three pathways: the canonical pathway and two non-canonical pathways. Moreover, it is generally accepted that both dysfunction of the Wnt signaling pathway, including mutations in the adenomatous polyposis coli (APC) and b-catenin genes, and genetic instability play important roles in colorectal carcinogenesis. However, alterations of the components of the Wnt signaling pathways in CRC have not been totally elucidated. Several studies support a possible role of Human Papillomavirus in colorectal carcinogenesis. The aim of this study was to comprehensively investigate the expression profiles of Wnt signaling components in HPV-positive and HPV-negative CRC cases using real-time PCR analysis. Methods: To determine the expression profile of the association of HPV and CRC, we conducted an age-matched case study in four HPV-positive and four HPV-negative CRC cases. We employed the Human WNT Signaling Pathway RT² Profiler PCR Array (Qiagen) to assay the expression of 84 genes related to WNT-mediated signal transduction. This array contains WNT signaling ligands and receptors as well as other downstream signaling molecules for all three WNT pathways. Results were evaluated with the RT² PCR Data Analysis Software provided by Qiagen. Results: Four male HPV-positive CRC cases (mean ages was 56 ± 2 years) and four HPV-negative CRC cases (mean ages 57 ± 2 years) were analyzed using the RT² Profiler™ PCR Array Human WNT Signaling Pathway (Qiagen). We detected a decrease in the expression levels of three WNT-canonical signaling molecules in HPV-positive CRC cases when compared to HPV-negative cases. The BCL9, LRP5 and WNT3 showed a 39% (p = 0.049), 43% (p = 0.020) and 60% (p=0.038) decrease in expression in HPV-positive cases, respectively. Reduced expression of three WNT signaling negative regulator genes was also observed: CTMP1 decreased 49% (p= 0.006), CXX4 decreased 49% (p=0.029) and FBXW11 expression decreased 41% (p = 0.041). Conclusion: Our findings suggest that colorectal tumors infected with HPV could define a non-described subtype of CRC based in the expression of a focused panel of genes related to WNT-mediated signal transduction. These results suggest an alteration of the WNT canonical pathway as a consequence of HPV infection in CRC. Citation Format: Raul D. Bernabe-Dones, Sharon C. Fonseca-Williams, Mercedes Y. Lacourt-Ventura, Cristina Munoz, Maribel Tirado-Gomez, Marcia R. Cruz-Correa. Expression of genes panel related to WNT- signaling in colorectal cancer Human Papillomavirus-positive colorectal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4783. doi:10.1158/1538-7445.AM2013-4783

Abstract 5569: DNA methylation status of MLH1, p16, SOCS1, ER and CDH1 in Puerto Rican patients with acute myeloid leukemia

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: DNA methylation of gene promoters have been show to play a role in the pathogenesis of acute myeloid leukemia (AML). We present in this study a preliminary report of the methylation status of MLH1, p16, SOCS1, ER and CDH1 in Puerto Rican patients with AML. Methods: Peripheral blood was obtained from 24 patients with diagnosis of acute myeloid leukemia before and after their induction treatments. DNA was isolated and further modified with sodium bisulfite. Methylation-specific polymerase (MSP) chain reaction was performed to detect aberrant promoter methylation of MLH1, p16, SOCS1, ER and CDH1. Results: Samples from a total of 24 patients were analyzed. The mean age was 47 years (range 22-70) with 21/24 patients younger than 60 years (88%). Most of the patients were female (13/24, 54%). Ten patients had diploid cytogenetics (42%), 4 had low risk cytogenetics (17%) and 10 had high risk cytogenetics (42%). Nineteen patients were de Novo AML (79%). Sixteen patients (67%) presented with WBC counts higher than 10 x 109/L. Seventeen patients (71%) achieved a complete response at the end of the induction therapy. Frequencies of gene methylation before treatment were as follows: MLH: 3/24 (13%); p16: 6/24 (25%); SOCS1:13/24 (54%); ER: 16/24 (67%) and CDH1: 4/24 (16.7%). Conclusions: No correlation between methylation status of p16 and MLH1 before treatment and clinicopathological characteristics was noted. Unmethylated CDH1 was more common among the novo AML patients. Methylation of SOCS1 was more common among patients that achieve a CR after induction therapy. This sample is a small one, so any correlation must be further tested in a more ample sample. Collection of more patients samples and correlation with clinical data and patients ultimate outcome is ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5569. doi:1538-7445.AM2012-5569

Abstract 2766: DNA methylation status of MLH1, p16 and SOCS1 in Puerto Rican patients with acute myeloid leukemia

Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: DNA methylation of gene promoters have been show to play a role in the pathogenesis of acute myeloid leukemia. We present in this study a preliminary report of the methylation status of MLH1, p16 and SOCS1 in Puertorrican patients with acute myeloid leukemia Methods: Peripheral blood was obtained from 24 patients with diagnosis of acute myeloid leukemia before their induction treatments. DNA was isolated and further modified with sodium bisulfite. Methylation-specific polymerase (MSP) chain reaction was performed to detect aberrant promoter methylation of MLH1, p16 and SOCS1. Results: A total of 24 samples were analyzed. The mean age was 49 years (range 22-71) with 17/24 patients younger than 60 years (71%). Most of the patients were female (13/24, 54%). Six patients had diploid cytogenetics (25%), 6 had low risk cytogenetics (25%) and 12 had high risk cytogenetics (50%). Fifteen patients were de Novo AML (63%). Nine patients (38%) presented with WBC counts higher than 10 × 109/L. Thirteen patients (54%) achieved a complete response at the end of the induction therapy. Methylation of MLH1 was detected in 3/24 patients (13%). Methylation of p16 was detected in 5/24 patients (21%). Methylation of SOCS1 was detected in 2/24 patients (8%). Conclusions: A tendency toward an association of methylated p16 with treatment resistance was noted. Also, methylation of SOCS1 was more common among relapsed AML patients. No correlation between methylated MLH1 gene and clinicopathological characteristics was noted. Collection of more patients samples and correlation with clinical data and patients ultimate outcome is ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2766. doi:10.1158/1538-7445.AM2011-2766