Marie Feuerstein

Efficient coupling of heteroaryl halides with arylboronic acids in the presence of a palladium–tetraphosphine catalyst

Abstract Cis , cis , cis -1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane:·1/2[PdCl(C 3 H 5 )] 2 system catalyses the Suzuki cross-coupling of heteroaryl halides with a range of arylboronic acids with very high ratio substrate/catalyst in good yields. Substrates such as pyridines, quinolines, thiophenes, an indole, pyrimidines or a furane have been used successfully.

Heck reaction with heteroaryl halides in the presence of a palladium-tetraphosphine catalyst

Abstract cis , cis , cis -1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/ 1 2 [PdCl(C3H5)]2 system catalyses efficiently the Heck reaction of heteroaryl halides with n -butyl acrylate, styrene, vinylpyridine and vinyl ether derivatives. High turnover numbers can be obtained for the reactions with halo pyridines, quinolines, furans or thiophenes.

Efficient coupling of heteroaryl bromides with arylboronic acids in the presence of a palladium-tetraphosphine catalyst

The cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H5)]2 system catalyses the Suzuki cross-coupling of heteroaryl bromides with arylboronic acids with a very high substrate/catalyst ratio in good yields. Substrates such as pyridines, quinolines, thiophenes, an indole, a pyrimidine or a furane have been used successfully.

A new efficient tetraphosphine/palladium catalyst for the Heck reaction of aryl halides with styrene or vinylether derivatives

Abstract cis , cis , cis -1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C 3 H 5 )] 2 system efficiently catalyses the Heck reaction of aryl halides with styrene and vinylether derivatives. High turnover numbers can be obtained for the reaction of several aryl halides with styrene and styrene derivatives. Lower turnover numbers have been observed in the presence of vinylethers.

Tetraphosphine/palladium-catalysed Suzuki cross-coupling with sterically hindered aryl bromides and arylboronic acids

cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H5)]2 system efficiently catalyses the Suzuki cross-coupling of sterically hindered substrates. Very high turnover numbers can be obtained for the coupling of sterically hindered aryl bromides with benzeneboronic acid or for the coupling of bromobenzene with sterically hindered arylboronic acids. On the other hand the formation of tri-ortho-substituted biaryl adducts requires higher catalyst loading.

Palladium-tetraphosphine complex: an efficient catalyst for the coupling of aryl halides with alkynes

The cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)-cyclopentane-[PdCl(eta3-C3H5)]2 system catalyses the coupling of aryl halides with alkynes with very high ratios of substrates-catalyst in good yields; a turnover number of 2600000 can be obtained for the reaction of 4-trifluoromethylbromobenzene with phenylacetylene in the presence of this catalyst.

Palladium-tetraphosphine catalysed allylic substitution in water

Abstract The cis , cis , cis -1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C 3 H 5 )] 2 system catalyses allylic amination in water with very high substrate/catalyst ratio in good yields. A turnover number of 980 000 can be obtained for the addition of dipropylamine to allyl acetate in the presence of this catalyst.

Palladium–tetraphosphine catalysed cross coupling of aryl bromides with arylboronic acids: remarkable influence of the nature of the ligand

The cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane –[PdCl(C3H5)]2 system catalyses the cross coupling of aryl bromides with arylboronic acids with very high substrate–catalyst ratios in good yields; a turnover number of 28000000 can be obtained for the addition of 4-bromobenzophenone to benzeneboronic acid in the presence of this catalyst.

Dramatic acceleration of the catalytic process of the amination of allyl acetates in the presence of a tetraphosphine/palladium system

The cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)-cyclopentan e/[PdCl(C3H5)]2 system catalyses allylic amination in good yields with a very high substrate/catalyst ratio; a turnover number of 680 000 and a turnover frequency of 8125 h−1 can be obtained for the addition of dipropylamine to allyl acetate in the presence of this catalyst.