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Dive into the research topics where Marie Maynadier is active.

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Featured researches published by Marie Maynadier.


Angewandte Chemie | 2011

Mannose‐Functionalized Mesoporous Silica Nanoparticles for Efficient Two‐Photon Photodynamic Therapy of Solid Tumors

Magali Gary-Bobo; Youssef Mir; Cédric Rouxel; David Brevet; Ilaria Basile; Marie Maynadier; Ophélie Vaillant; Olivier Mongin; Mireille Blanchard-Desce; Alain Morère; Marcel Garcia; Jean-Olivier Durand; Laurence Raehm

In the context of national systematic screenings for cancer,photodynamic therapy (PDT) has arisen as an alternative tochemo- and radiotherapy for the non-invasive selectivedestruction of small tumors. PDT involves the use of aphotosensitizer which, upon irradiation at specific wave-lengths, in the presence of oxygen, leads to the generation ofcytotoxic species and consequently to irreversible celldamage.


Advanced Materials | 2014

Biodegradable Ethylene‐Bis(Propyl)Disulfide‐Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In‐Vitro Drug Delivery

Jonas G. Croissant; Xavier Cattoën; Michel Wong Chi Man; Audrey Gallud; Laurence Raehm; Philippe Trens; Marie Maynadier; Jean-Olivier Durand

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.


International Journal of Pharmaceutics | 2012

Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT.

Magali Gary-Bobo; Ouahiba Hocine; David Brevet; Marie Maynadier; Laurence Raehm; Sébastien Richeter; Virginie Charasson; Bernard Loock; Alain Morère; Philippe Maillard; Marcel Garcia; Jean-Olivier Durand

The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anti-cancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments.


Small | 2014

Two‐Photon‐Triggered Drug Delivery via Fluorescent Nanovalves

Jonas G. Croissant; Arnaud Chaix; Olivier Mongin; Miao Wang; Sébastien Clément; Laurence Raehm; Jean-Olivier Durand; Vincent Hugues; Mireille Blanchard-Desce; Marie Maynadier; Audrey Gallud; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Daniel P. Ferris; Derrick Tarn; Jeffrey I. Zink

Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section. The pores of the MSN filled with anticancer drug are blocked with a pseudo-rotaxane constituted by an azobenzene stalk and a β-cyclodextrin moiety. After incubation of the nanosystem with MCF-7 breast cancer cells, two-photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two-photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN.


Advanced Materials | 2014

Two‐Photon Excitation of Porphyrin‐Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy

Emilie Secret; Marie Maynadier; Audrey Gallud; Arnaud Chaix; Elise Bouffard; Magali Gary-Bobo; Nathalie Marcotte; Olivier Mongin; Khaled El Cheikh; Vincent Hugues; Mélanie Auffan; Céline Frochot; Alain Morère; Philippe Maillard; Mireille Blanchard-Desce; Michael J. Sailor; Marcel Garcia; Jean-Olivier Durand; Frédérique Cunin

Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.


International Journal of Pharmaceutics | 2010

Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

Ouahiba Hocine; Magali Gary-Bobo; David Brevet; Marie Maynadier; Simon Fontanel; Laurence Raehm; Sébastien Richeter; Bernard Loock; Pierre Couleaud; Céline Frochot; Clarence Charnay; Gaelle Derrien; Monique Smaïhi; Amar Sahmoune; Alain Morère; Philippe Maillard; Marcel Garcia; Jean-Olivier Durand

The synthesis of silicalites and Mesoporous Silica Nanoparticles (MSN), which covalently incorporate original water-soluble photosensitizers for PDT applications is described. PDT was performed on MDA-MB-231 breast cancer cells. All the nanoparticles showed significant cell death after irradiation, which was not correlated with (1)O(2) quantum yield of the nanoparticles. Other parameters are involved and in particular the surface and shape of the nanoparticles which influence the pathway of endocytosis. Functionalization with mannose was necessary to obtain the best results with PDT due to an active endocytosis of mannose-functionalized nanoparticles. The quantity of mannose on the surface should be carefully adjusted as a too high amount of mannose impairs the phototoxicity of the nanoparticles. Fluorescein was also encapsulated in MCM-41 type MSN in order to localize the nanoparticles in the organelles of the cells by confocal microscopy. The MSN were localized in lysosomes after active endocytosis by mannose receptors.


Angewandte Chemie | 2013

Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers†

Jonas G. Croissant; Marie Maynadier; Audrey Gallud; Harmel W. Peindy N'dongo; Jeff L. Nyalosaso; Gaelle Derrien; Clarence Charnay; Jean-Olivier Durand; Laurence Raehm; Françoise Serein-Spirau; Nathalie Cheminet; Thibaut Jarrosson; Olivier Mongin; Mireille Blanchard-Desce; Magali Gary-Bobo; Marcel Garcia; Jie Lu; Fuyuhiko Tamanoi; Derrick Tarn; Tania M. Guardado-Alvarez; Jeffrey I. Zink

A therapy of cancer cells: Two-photon-triggered camptothecin delivery with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.


International Journal of Pharmaceutics | 2012

Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy

Magali Gary-Bobo; Youssef Mir; Cédric Rouxel; David Brevet; Ouahiba Hocine; Marie Maynadier; Audrey Gallud; Afitz Da Silva; Olivier Mongin; Mireille Blanchard-Desce; Sébastien Richeter; Bernard Loock; Philippe Maillard; Alain Morère; Marcel Garcia; Laurence Raehm; Jean-Olivier Durand

In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.


Chemical Communications | 2013

Anionic porphyrin-grafted porous silicon nanoparticles for photodynamic therapy

Emilie Secret; Marie Maynadier; Audrey Gallud; Magali Gary-Bobo; Arnaud Chaix; Emmanuel Belamie; Philippe Maillard; Michael J. Sailor; Marcel Garcia; Jean-Olivier Durand; Frédérique Cunin

Non-toxic porous silicon nanoparticles carry porphyrin covalently attached to their surface inside breast cancer cells for a more efficient photodynamic effect.


Small | 2015

Enhanced Two‐Photon Fluorescence Imaging and Therapy of Cancer Cells via Gold@Bridged Silsesquioxane Nanoparticles

Jonas G. Croissant; Marie Maynadier; Olivier Mongin; Vincent Hugues; Mireille Blanchard-Desce; Arnaud Chaix; Xavier Cattoën; Michel Wong Chi Man; Audrey Gallud; Magali Gary-Bobo; Marcel Garcia; Laurence Raehm; Jean-Olivier Durand

A two-photon photosensitizer with four triethoxysilyl groups is synthesized through the click reaction. This photosensitizer allows the design of bridged silsesquioxane (BS) nanoparticles through a sol-gel process; moreover, gold core BS shells or BS nanoparticles decorated with gold nanospheres are synthesized. An enhancement of the two-photon properties is noted with gold and the nanoparticles are efficient for two-photon imaging and two-photon photodynamic therapy of cancer cells.

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Marcel Garcia

French Institute of Health and Medical Research

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Jean-Olivier Durand

Centre national de la recherche scientifique

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Laurence Raehm

Centre national de la recherche scientifique

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Alain Morère

Centre national de la recherche scientifique

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Audrey Gallud

University of Montpellier

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Olivier Mongin

Centre national de la recherche scientifique

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Michel Wong Chi Man

Centre national de la recherche scientifique

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Jonas G. Croissant

King Abdullah University of Science and Technology

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