Mario Abbruzzese

Prevalence of cutaneous manifestations in 200 patients with eating disorders

Background Eating disorders are increasing and show a variety of symptoms. They mainly include anorexia nervosa (AN), bulimia nervosa (BN), and eating disorders not specified (EDNOS). They predominate in females and represent an important danger, especially in teenagers. In serious cases, they may be life‐threatening.

Nevoid keratosis of the nipple

A patient with nevoid keratosis of the nipple is described. The clinical features, histology, therapy, and prognosis are discussed.

Primary amelanotic melanoma of the esophagus

Primary melanoma of the esophagus (PME) is an uncommon malignancy with less than 250 cases reported in the literature. Amelanotic PME is exceedingly rare and accounts for 10–25% of melanomas of the esophagus. A 59‐year‐old male with a history of mild dysphagia, heartburn, moderate anorexia and weight loss for 1 month is described. Barium swallow examination and videogastroscopy showed a polypoid, ulcerated mass located 30–38 cm from the incisors. No skin or eye melanoma lesions were found. Five biopsy samples were obtained. Histological examinations revealed proliferation of large, loosely cohesive cells of variable shapes and prominent central nucleoli in the deep mucosa. Immunohistochemical findings included positive vimentin, protein S‐100, Melan A, and HMB‐45, and negative AE1/AE3, CD 17, and desmin. A total transhiatal esophagectomy with high cervical esophagogastric anastomosis was performed. Peritumoral lymph nodes revealed malignant invasion. A diagnosis of primary amelanotic melanoma of the esophagus was made. Fourteen months after diagnosis the patient developed disseminated PME.

Lichenoid secondary syphilis

Argentina Case 1 A married, heterosexual, promiscuous, 29‐year‐old white man had experienced an asymptomatic eruption on the trunk and left palm for the last 3 months. After 2 months, the trunk involvement disappeared, but 2 weeks later lip and tongue lesions developed. No history of genital ulcer was found.

Metastatic involvement of four eyelids

CASE REPORT A 58-year-old woman had a right radical mastectomy in 1973 and several courses of chemotherapy. Five years later progressive eyelid inflammation, induration, and narrowing of the palpebral fissures occurred. Peritoneal involvement was noted. Both eyes showed palpebral overlapping, swelling, red discoloration, and woody induration that precluded the assessment of the eyeballs (Fig. 1). 1 A biopsy specimen of the left lower eyelid showed epidermal atrophy and edema associated with blood and lymph vessel enlargement in the papillary dermis. The reticular dennis was hypertrophic, and confluent cords of cuboid cells with a pale cytoplasm and a hyperchromatic nucleus invaded the connective tissue (Fig. 2). No inflammatory infiltrate was present. The adnexa were atrophic. A diagnosis of skin metastasis from breast carcinoma was made. A specimen from the right lower eyelid had similar features. Roentgenograms demonstrated spine and peritoneal metastases. The patient received 3000 rads to each eye, but died 4 months later.