Mario Gonzalez-Hevilla

A new HLA-B15 allele (B*1541) found in a Mexican of Nahua (Aztec) descent

The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the following accession numbers: B*1541, a) exon 2, AF033501, b) exon 3, AF033502, c) intron 1, AF034961, d) intron 2, AF034962. The name B*1541 was officially assigned by the WHO Nomenclature Committee in January 1998. This follows the agreed policy that, subject to the conditions stated in the most recent Nomenclature Report (Bodmer et al 1997), names will be assigned to new sequences as they are identified. A list of such new names will be published in the following WHO Nomenclature Report.

Human leukocyte antigen haplotypes and HFE mutations in Spanish hereditary hemochromatosis and sporadic porphyria cutanea tarda

Background and Aims:  It has been postulated that the HFE C282Y mutation (linked to human leukocyte antigen [HLA]‐A3‐B7 haplotype) is not only responsible for hereditary hemochromatosis; HLA class I alleles would also contribute to the disease pathogenesis. In addition, H63D mutation linked to HLA‐A29‐B44 would also be pathogenetic, particularly in the Mediterranean Basin and throughout the world. However, sporadic porphyria cutanea tarda (s‐PCT) has also been linked to these HFE mutations. In the present work, we have studied HFE mutations and HLA genes to test these hypotheses.

A novel HLA-A*6816 allele possibly generated by a point mutation in a Chilean from Punta Arenas (Magellan Strait)

The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned accession number AF 144013. The name A*6816 was officially assigned by the WHO Nomenclature Committee in November 1999. This follows the agreed policy that, subject to the conditions stated in the most recent Nomenclature Report (Bodmer et al. 1999), names will be assigned to new sequences as they are identified. Lists of such new names will be published in the following WHO Nomenclature Report.