Mario L. Aimar

One-pot synthesis of 3H-1,2-dithiole-3-thione derivatives from dithiolmalonic esters

Abstract The reaction of dithiolmalonic esters with P 2 S 5 /S 8 in boiling xylene and with 2-mercaptobenzothiazole/ZnO as catalyst produces 5-R (R=alkyl or aryl) thio-3 H -1,2-dithiole-3-thiones as the major identifiable product. The use of Lawessons reagent as sulfurizing agent gives even better yields. For instance with R=phenyl the yield rises from 44 to 82%.

One-pot synthesis of 5-alkylthio-3H-1,2-dithiole-3-thiones

Abstract Dialkyl malonate esters reacted with P 2 S 5 S 8 in boiling xylene and with 2-mercaptobenzothiazole ZnO as catalyst to yield 5-alkylthio-3H-1,2-dithiole-3-thiones as major products.

Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks.

Abstract Context Coriandrum sativum L. (Apiaceae) (coriander) is an herb grown throughout the world as a culinary, medicinal or essential crop. In traditional medicine, it is used for the relief of anxiety and insomnia. Systemic hydro-alcoholic and aqueous extract from aerial parts and seeds had anxiolytic and sedative action in rodents, but little is known about its central effect in chicks. Objective To study the effects of intracerebroventricular administration of essential oil from coriander seeds and its major component linalool on locomotor activity and emotionality of neonatal chicks. Materials and methods The chemical composition of coriander essential oil was determined by a gas-chromatographic analysis (> 80% linalool). Behavioural effects of central administration of coriander oil and linalool (both at doses of 0.86, 8.6 and 86 μg/chick) versus saline and a sedative diazepam dose (17.5 μg/chick, standard drug) in an open field test for 10 min were observed. Results Doses of 8.6 and 86 μg from coriander oil and linalool significantly decreased (p < 0.05) squares crossed number, attempted escapes, defecation number and distress calls, and significantly increased (p < 0.05) the sleeping posture on an open field compared with saline and were similar to the diazepam group. Discussion and conclusion The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 μg doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam.

Fruits of the glossy privet (Ligustrum lucidum—Oleaceae) as biocatalysts for producing chiral aromatic alcohols

Abstract The screening of four invasive plant species for use as biocatalysts in the stereoselective reduction of ketones is reported. Our studies revealed that fruits of Ligustrum lucidum can be used for the bioreduction of acetophenone to (S)-1-phenylethanol (94% conversion, > 99 enantiomeric excess [ee]%). Using this methodology, 13 substituted (S)-phenylethanols were synthesized with good ee values (> 99.9 to 78%) using a technique which is more environmentally friendly than classical reduction of prochiral ketones. The results reveal the fruits of L. lucidum to be promising biocatalysts for the production of key intermediates.

Volatile Organic Constituents of Clinopodium gilliesii (Benth.) Kuntze: Analysis by HS-SPME and classic hydrodistillation

In the present research, an analytical methodology to micro scale based on the use of the HS-SPME/GC-MS to determine volatile compounds present in Clinopodium gilliesii (Benth.) Kuntze (Lamiaceae) was employed, and settled differences and similarities with its essential oil obtained by hydrodistillation. A systematic description of the volatile components of flowers, stems, leaves and combined aerial parts (whole plant) was constructed via GC-MS analyses of HS-SPME adsorbed compounds and of essential oils obtained through hydrodistillation of the same tissues. Piperitenone oxide and piperitone oxide were the main components of both the HS-SPME analysis and essential oil analysis. The HS-SPME method can achieve comparable results to those obtained by essential oil analysis, by using very fewer samples, a shorter extraction time and a much simpler procedure. Para citar este articulo Vazquez, A., Aimar, M.,Decarlini, M., Demmel, G., Cantero, J y Ruiz, G. (2016). Volatile Organic Constituents of Clinopodium gilliesii (Benth.) Kuntze: Analysis by HS-SPME and classic hydrodistillation. Rev. Colomb. Investig. Agroindustriales, 3(1), 91-100. DOI: http://dx.doi.org/10.23850/24220582.351