Mario Sofer

Ureteral segmental replacement using multilayer porcine small-intestinal submucosa.

PURPOSE To assess the outcome of segmental ureteral replacement using a new multilayer porcine small-intestinal submucosa (SIS), Surgisis ES (Cook Inc., Stouffville, ON, Canada) designed to provide enhanced strength. MATERIALS AND METHODS The ureters of five female farm pigs were accessed through a median laparotomy incision. A segment of 2-cm midureter was resected bilaterally. The left ureteral segments were replaced by 10F tubularized SIS segments using 5-0 PDS interrupted sutures. The right ureters were primarily end-to-end anastomosed, serving as controls. Internal pigtail stents were left bilaterally for 6 weeks. One animal at 3 weeks, one animal at 6 weeks, and three animals at 12 weeks were sacrificed. The patency of the ureters was assessed by retrograde pyelography at 6 and 12 weeks, while inflammation and regeneration were assessed grossly and histologically. RESULTS At 3 and 6 weeks, both experimental and control ureters were patent without extravasation on retrograde studies. Adhesions and signs of ureteral inflammation were found only on the SIS side. The graft was partially and completely epithelialized at 3 and 6 weeks, respectively. However, at 12 weeks, all the ureters on the experimental side were completely occluded, while on the control side, all were patent. Although histologically, urothelium and muscular cells had proliferated over the graft, they were embedded in an intense fibrotic and inflammatory process. At 12 weeks, all animals had developed hydroureteronephrosis above the grafts. CONCLUSIONS Technically, Surgisis ES was easily modeled, providing conditions for a water-tight anastomosis. None of the animals developed urinary fistula. Regeneration of urothelium and muscle were induced and supported by the graft. However, functional replacement was not successful. A suitable material for this purpose has yet to be discovered.

Bilateral endoscopic surgery for renal stones: a systematic review of the literature

INTRODUCTION The aim of this study was to evaluate the current literature on single-session bilateral endoscopic surgery for renal stones, analyzing their effectiveness and safety. EVIDENCE ACQUISITION A systematic literature review was performed to identify articles published between 1995 and July 2016 that reported data on bilateral single-session endoscopic surgery for renal stones. Articles were separated into the following categories: bilateral PCNL, bilateral FURS and bilateral PCNL with contralateral FURS. We used a narrative synthesis for the analyses of the studies. EVIDENCE SYNTESIS Five reports of bilateral FURS were identified in the literature search. These studies included a total of 218 patients that underwent bilateral FURS for renal stones. The primary SFR ranged from 64% to 92.8%. Postoperative complications were mostly described as minor complications; one major complication (0.5%) (grade V) was reported. Thirteen reports of bilateral PCNL were identified. These case studies included a total of 729 patients undergoing bilateral PCNL for renal stones. The primary SFR ranged from 24% to 100%. In all the studies a total of 29 (4%) major complications were described: 28 of them grade III while one was grade IV. One single study of bilateral PCNL with contralateral FURS for renal stones was identified. This report included 26 patients and the primary SFR was 92.3%. Two major complications (7.7%) (Grade III) were described. CONCLUSIONS Bilateral single-session endoscopic procedures for bilateral renal stones are effective and safe. It should be considered a viable treatment option in carefully selected patients, performed by experienced urologists in high-volume centers. Key to success is the proper selection of patients and extending surgery on the second side only when the first side has been uneventful.

Sulfadiazine-Induced Obstructive Nephropathy Presenting with Upper Urinary Tract Extravasation

Abstract Background: Obstructive nephropathy is an uncommon side effect of sulfadiazine, which is used for the treatment of toxoplasmosis. We present a case of acute renal colic and urine extravasation of a patient shortly after she was started on this medication. Case Presentation: A 31-year-old female presented with acute renal colic 2 weeks after starting treatment with sulfadiazine and pyrimethamine for ocular toxoplasmosis. Results: A noncontrast computed tomography revealed left hydronephrosis and fluid located around the kidney and in the left gutter. There were no urinary stones. Administration of intravenous contrast revealed significant urine extravasation at the level of the ureteropelvic junction. Intravenous contrast injection confirmed that the extravasation consisted of urine leakage at the ureteropelvic junction. Her clinical condition improved with the insertion of an internal stent, which was left in place for 4 weeks. A retrograde pyelography performed at the time of the internal stent removal ruled out persistent extravasation and filling defects in the left upper urinary tract. Considering the clinical circumstances and the imaging results, it appears that this is a first reported case of sulfadiazine-induced obstructive uropathy associated with urine extravasation. Conclusion: Although rare, obstructive uropathy related to sulfadiazine medication should be promptly suspected, diagnosed, and treated. Patients should be instructed to substantially increase their liquid intake while on that medication.

Ventral Plication for Repair of Pediatric Dorsal Penile Curvature

OBJECTIVES To present the results of ventral plication for the repair of dorsal curvature. METHODS A total of 33 patients (mean age 38 months, range 7 months to 15 years) with a dorsal curvature of >30 degrees degrees underwent ventral plication. A subcoronal incision was performed, followed by degloving of the skin to the penile base. The point of maximal curvature was noted and marked during an erection test. Two polypropylene 5-0 plication sutures were placed in the tunica albuginea of both corporeal bodies, just lateral and adjacent to the corpus spongiosum. Proper alignment and a straight penis were confirmed with a repeat erection test. The skin incision was closed with absorbable sutures. Surgical success was determined by parental and physician satisfaction with the final outcome during follow-up. RESULTS No immediate or late complications (mean follow-up 25 months, range 3-65) developed. A straight penis was achieved in 28 of 33 patients (85%). Four patients with residual curvature did not require a second procedure, and the fifth patient successfully underwent reoperation using the same technique. CONCLUSIONS The results of our study have shown that ventral plication is a simple and efficient technique for the repair of dorsal penile curvature.

A Novel Method for Re-Positioning Suboptimally Preoperatively Placed Nephrostomy Tubes for PCNL without Renal Re-Puncture

OBJECTIVE Nephrostomy tubes (NTs) inserted in emergency settings by interventional radiologists are frequently unsuitable for subsequent percutaneous nephrolithotomy (PCNL). We report a novel method of adjusting these NTs to be used as PCNL tracts and avoid renal repuncture. PATIENTS AND METHODS A retrospective search of 981 consecutive PCNLs performed in our institution between 2002 and 2017 identified all patients with preoperatively inserted NTs. The NTs unsuitable for PCNL were adjusted by a novel approach in which a 5-mm incision was made at the ideal puncture location (IPL) as indicated under fluoroscopic guidance. The preinserted NT was removed after passing a guidewire into the kidney. A dissector clamp was introduced through the entry wound of the removed NTs to bluntly dissect a retroperitoneal tunnel and pull out the distal tip of guidewire through the IPL, while its proximal segment was maintained in the kidney. The newly positioned guidewire was used for PCNL tract preparation without repuncturing the kidney. RESULTS The NTs were located in the mid calix, lower calix, and renal pelvis in 6 (26%), 13 (57%), and 4 (17%) cases, respectively. The NT was suitable for PCNL in 5 (22%) cases, a new renal access was performed in 3 (13%), and the novel adjustment approach was used in 15 (65%), all successfully. The place of entry was moved an average of 6 cm (range 47) and the angle between the tract axis and the calix axis was reduced by 65° in average. The procedure was done uneventfully in an average of 4 minutes. CONCLUSIONS The novel method of adjusting preoperatively inserted NTs for PCNL by repositioning their original entry location to the IPL offers the possibility of avoiding kidney repuncture. It is feasible, safe, and easy to implement, and it spares potential morbidity related to additional puncturing of the kidney.

V12-01 MULTIMODAL ENHANCED CYSTOSCOPY FOR IMPROVED BLADDER TUMOR RESECTIONS

LN group. The patient’s mean scar satisfaction score was higher in the LESS group (9.3 vs 8.3, p1⁄40.003). The mean days off work (20.7 vs 27.3 days, p1⁄40.07), the mean number of days to 100% activity (53.7 vs 70.6, p1⁄40.14) and the score given to the overall experience by the patient (8.8 vs 8.4, p1⁄40.3) did not differ significantly between the 2 groups CONCLUSIONS: LESS-N offers a superior cosmetic outcome compared to LN on the expense of operative time and surgical difficulty. However, the LN group also enjoyed excellent scar satisfaction. Many studies showed that the importance of cosmesis is more evident in younger patients and those with non-oncological conditions. We believe that the choice for LESS nephrectomy should be tailored to each specific patient according to his age, individual perception of scar importance, indication for nephrectomy and size of kidney to be removed rather than offering it unanimously to all our nephrectomy population

MP78-11 POSITIVE PREDICTIVE VALUE OF CT UROGRAPHY FOR UPPER TRACT UROTHELIAL CARCINOMA DIAGNOSIS USING DIAGNOSTIC URETEROSCOPY AS THE REFERENCE STANDARD

INTRODUCTION AND OBJECTIVES: We reported the lack of therapeutic effect of lymphadenectomy on lower ureteral cancer (LUC). We further examined this mechanism by analyzing the recurrence pattern and factors influencing the outcome of LUC. METHODS: From January 1988 to September 2016, we performed radical nephroureterectomy for 83 patients with non-metastatic (clinically N0 M0) LUC at two Japanese institutes. The lower ureter was designated as located below the crossing of the common iliac artery. Metastatic sites were identified with radiological imaging studies or resected specimens. Regional nodes of LUC were identified as ipsilateral pelvic nodes below the aortic bifurcation, according to the description in our previous study. RESULTS: The mean age of the 83 patients was 71.2 years (range: 38e90 years), and the mean follow-up period was 48 months (range: 2e225 months). Radical nephroureterectomy was performed for 41 patients with right LUC and for 42 patients with left LUC. No significant difference was found in the patients who underwent templatebased lymphadenectomy (34% in the right and 36% in the left LUC, p1⁄40.88). The 5-year recurrence-free and cancer-specific survival rates were respectively 71.9% and 80.1% in the right LUC, and 50.6% and 62.7% in the left LUC. The difference was statistically significant (p1⁄40.02 and 0.03, respectively; Figure 1). The incidence of lymph node recurrence was even higher in the patients with left LUC (24%) than in those with right LUC (2%), and 60% of the lymph node recurrences occurred at the extraregional nodes in the left LUC. The multivariate analysis revealed that the factors that influenced cancer-specific survival were left ureteral tumors (hazard ratio [HR], 3.38; p1⁄40.02) and pathological stage T3 or higher (HR, 28.9; p1⁄40.002). Template-based lymphadenectomy or adjuvant chemotherapy was not a significant factor. CONCLUSIONS: This multi-institutional study shows a higher risk of extraregional nodes recurrence after nephroureterectomy in patients with left LUC, which is likely to be associated with worse oncological outcome of left LUC than right LUC. Template-based lymphadenectomy alone appears inadequate to improve patient survival in left LUC.

MP01-18 PRECIPITATION (AND NOT TEMPERATURE) IS ASSOCIATED WITH URINARY STONE DISEASE IN CALIFORNIA

INTRODUCTION AND OBJECTIVES: It is commonly accepted that increased temperatures are associated with increased prevalence of kidney stone disease. When examining stone mapping studies of the United States, while some regions with high annual temperatures (the southeast) have higher kidney stone prevalence, other warm regions such as the southwest do not. One major climate difference between these two regions is annual precipitation and humidity. We sought to explore the associations among, temperature, precipitation and urinary stone disease. METHODS: We identified all patients who underwent ureteroscopy, percutaneous nephrolithotomy, or shock wave lithotripsy using data from the Office of Statewide Health Planning and Development (OSHPD) for the state of California (2010-2012). We calculated the rate of operative stone disease for each county based on the patient’s home zipcode. We obtained climate data for each county in California from the National Oceanic and Atmospheric Administration. We compared the rate of urinary stone surgeries, adjusted for county population, mean annual temperature, total number of days over 90 degrees, and the total annual precipitation. RESULTS: A total of 63,994 unique patients underwent stone procedures in California between 2010-2012. The mean county stone surgery rate was 1.77 cases per 1000 persons (range 0.05-3.16). In the lowest quartile of rainfall (less than 21 inches per year), the average stone surgery rate was 1.5 per 1000 persons. This was significantly less than 2.2 per 1000 persons in the regions with the highest quartile of rainfall (44 inches per year) (p<0.01). In fully-adjusted models, precipitation (0.019 increase in surgeries per 1000 persons per inch, p<0.01) and higher mean temperature (0.029 increase in surgeries per 1000 persons per degree, p<0.01) were associated with an increased rate of stone surgery (Figure 1). The effect of temperature was not significant unless precipitation was controlled for. CONCLUSIONS: In the state of California, temperature alone is not associated with the county-level rate of stone surgery until precipitation is included in models. Our results appear to agree with the larger trends seen through the United States where the areas of highest stone prevalence have warm humid climates, and not warm arid, climates.

MP10-10 CAN UROLOGISTS ACCURATELY STAGE AND GRADE UROTHELIAL CARCINOMA BY ASSESSING ENDOSCOPIC PHOTOGRAPHS OF TUMORS?

INTRODUCTION AND OBJECTIVES: Assessment of urothelial carcinoma (UC) during cystoscopy or TURBT has a significant impact on the urologist’s decision making: treatment with simple outpatient fulguration, the required depth of resection and the need of immediate post-surgical intravesical therapy all depend heavily on the urologist’s ability to accurately assess pre-biopsy tumor stage and grade. METHODS: Photographs of 50 UC were taken at the beginning of TURBT and were presented to 7 senior urologists separately, all blind to the pathological report. Each urologist was asked to rate the tumor as low grade and noninvasive (Ta low grade), high grade and noninvasive (Ta high grade) or invasive (T1 or more). Results were compared with the final pathological findings. RESULTS: The single urologist correctly predicted the tumor stage and grade in 63.5% of cases (222 of 350, average of 32 out of 50 accurate assessments). Of the 128 incorrect assessments 54 underestimated the UC and 74 overestimated it. After achieving consensus in each case it turned out that the final majority assessment was correct in 40 of 50 cases (80%). Sensitivity and specificity of the final results for the diagnosis of T1 or higher were 80% and 88.6% respectively. Sensitivity and specificity for TaLG were 83.3% and 80% respectively. Inter-rater reliability was calculated and showed fair agreement (kappa1⁄40.27). CONCLUSIONS: To our knowledge this is the first documented evaluation of urologists’ ability to assess UC stage and grade using endoscopic photographs. The single urologist can usually identify stage and grade of UC but accuracy increases when multiple senior urologists examine the photos and achieve consensus. When photos of UC exist, a team of senior urologists can make an excellent decision about the type and extent of surgical treatment and plan ahead post-surgical management of the patient.

Can intraprostatic stent failure be predicted? Experience based on long-term follow-up of 107 patients

SummaryVarious prognostic factors which could be implicated in late complications associated with intraurethral stents and coils were evaluated. A consecutive series of 107 subjects with BPH or prostatic cancer who required intraurethral stents and randomly received either the Prostakathr` or Urospiralr` type were followed for 2–7 years. Data on stent-associated complications were collected. Factors directly associated with the complication rate were the pre-treatment presence of an indwelling catheter and asymptomatic bacteriuria, as well as post-treatment low urinary flow rate. Stent type and length did not influence outcome. It is concluded that in selected patients, either of the two studied intraurethral stents is a feasible and durable treatment. Men with indwelling catheters and/or bacteremia are at high risk of complications (e.g. migration, stone formation, strictures), as are those with post-stent insertion low uroflow. Although stents may be left in situ for years, these subgroups of men should...