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Featured researches published by Marja Södervall.


Cancer Chemotherapy and Pharmacology | 1986

A new triphenylethylene compound, Fc-1157a

Sinikka Kallio; Lauri Kangas; Guillermo Blanco; Risto Johansson; Arto Karjalainen; Milla Perilä; Ilse Pippo; Hannu Sundquist; Marja Södervall; Reijo Juhani Toivola

SummaryThe basic pharmacological and biochemical properties of a new antiestrogen, Fc-1157a, are described. Fc-1157a is bound specifically and with high affinity to estrogen receptors. The binding is competitive with estradiol. Fc-1157a treatment induces translocation of estrogen receptors from cytoplasm to nucleus. The turnover rate of nuclear estrogen receptors is markedly lower than with estradiol, but is more rapid than after tamoxifen.Fc-1157a is an almost pure antiestrogen in rat uterus, but has intrinsic estrogenic activity in mouse uterus. In animal experiments Fc-1157a has shown antitumor properties, which are described in the companion paper.


Journal of Steroid Biochemistry | 1990

Metabolism of toremifene in the rat

Hannu Sipilä; Lauri Kangas; Lauri Vuorilehto; Arm Kalapudas; Maire Eloranta; Marja Södervall; Reijo Juhani Toivola; Markku Anttila

Toremifene was labelled to a specific activity of about 20 microCi/mmol with tritium at positions 3 and 5 in the para-substituted phenyl ring. At these positions tritium is not eliminated within the metabolic pathways. A mixture of unlabelled and labelled toremifene (5 or 10 mg/kg, 5 microCi/mg) was given i.v. or p.o. to Sprague-Dawley rats. The elimination of radioactivity was followed up by collecting urine and feces daily for 13 days. The elimination of toremifene which was similar after p.o. and i.v. administration took place mainly in the feces. About 70% of the total radioactivity was eliminated within 13 days, of this amount more than 90% in the feces. All applied radioactivity could be detected in three separate fractions according to the oxidative state of the side chain when counted by Berthold TLC Linear Analyzer. Each fraction was further separated into single metabolites by TLC or HPLC. Altogether 9 metabolites were identified and almost all methanol-extractable components were identified. The main metabolic pathways in the rat were 4-hydroxylation and N-demethylation. The side chain was further oxidized to alcohols and carboxylic acids. Small amounts of unchanged toremifene were found in the feces both after p.o. and i.v. administration indicating biliary secretion.


European Journal of Pharmaceutical Sciences | 2000

Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons

Arto Karjalainen; Arja Kalapudas; Marja Södervall; Olavi Pelkonen; Risto Lammintausta

A series of long-chained diarylalkylimidazoles and diarylalkyltriazoles were synthesized and evaluated for the inhibitory potency for aromatase (estrogen synthetase) activity in human placental microsomes. The relative specificity of inhibition was evaluated by measuring the inhibition of cholesterol side-chain cleavage enzyme (desmolase) in human placental mitochondria and the inhibition of 7-ethoxycoumarin O-deethylase (a typical drug-metabolizing enzyme activity) in rat liver microsomes. The structural requirements including substituent effects for the strongest potency and for the highest specificity were delineated. alpha,omega-Diarylalkyltriazoles and imidazoles were the most interesting molecules, in which the geometric and optical isomerism displayed remarkable selectivity for aromatase inhibition.


Cancer Chemotherapy and Pharmacology | 1986

A new triphenylethylene compound, Fc-1157a. II. Antitumor effects.

Lauri Kangas; Nieminen Al; Guillermo Blanco; Grönroos M; Kallio S; Arto Karjalainen; Perilä M; Marja Södervall; Reijo Juhani Toivola


Cancer Chemotherapy and Pharmacology | 1986

A new triphenylethylene compound, Fc-1157a. I. Hormonal effects.

Kallio S; Lauri Kangas; Guillermo Blanco; Johansson R; Arto Karjalainen; Perilä M; Pippo I; Hannu Sundquist; Marja Södervall; Reijo Juhani Toivola


Archive | 2008

Method for the preparation of therapeutically valuable triphenylbutene derivatives

Marja Södervall; Maire Eloranta; Arja Kalapudas


Archive | 2002

A new method for the preparation of 2- 2- 4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy ethanol and its isomers

Arja Kalapudas; Marja Södervall


Archive | 2008

Methods for the preparation of fispemifene from ospemifene

Marja Södervall; Maire Eloranta; Arja Kalapudas; Brian Kearton; Michael McKenzie


Archive | 2008

Method for preparing derivatives with therapeutic value trifenilbuteno

Marja Södervall; Maire Eloranta; Arja Kalapudas


Archive | 2008

Verfahren zur Herstellung von therapeutisch nützlichen Triphenylbutenderivaten

Marja Södervall; Maire Eloranta; Arja Kalapudas

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