Mark I. McCarthy
King's College London
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Mark I. McCarthy.
American Journal of Human Genetics | 2001
Steven Wiltshire; Andrew T. Hattersley; Graham A. Hitman; M. Walker; Jonathan C. Levy; Mike Sampson; Stephen O’Rahilly; Timothy M. Frayling; John I. Bell; G. Mark Lathrop; Amanda J. Bennett; Ranjit Dhillon; C Fletcher; Christopher J. Groves; Elizabeth Jones; Philip Prestwich; Nikol Simecek; Pamidighantam V. Subba Rao; Marie Wishart; Richard Foxon; Simon L. Howell; Damian Smedley; Lon R. Cardon; Stephan Menzel; Mark I. McCarthy
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current therapeutic and preventative options are to be extended. To identify diabetes-susceptibility genes, we have completed a primary (418-marker, 9-cM) autosomal-genome scan of 743 sib pairs (573 pedigrees) with type 2 diabetes who are from the Diabetes UK Warren 2 repository. Nonparametric linkage analysis of the entire data set identified seven regions showing evidence for linkage, with allele-sharing LOD scores > or =1.18 (P< or =.01). The strongest evidence was seen on chromosomes 8p21-22 (near D8S258 [LOD score 2.55]) and 10q23.3 (near D10S1765 [LOD score 1.99]), both coinciding with regions identified in previous scans in European subjects. This was also true of two lesser regions identified, on chromosomes 5q13 (D5S647 [LOD score 1.22] and 5q32 (D5S436 [LOD score 1.22]). Loci on 7p15.3 (LOD score 1.31) and 8q24.2 (LOD score 1.41) are novel. The final region showing evidence for linkage, on chromosome 1q24-25 (near D1S218 [LOD score 1.50]), colocalizes with evidence for linkage to diabetes found in Utah, French, and Pima families and in the GK rat. After dense-map genotyping (mean marker spacing 4.4 cM), evidence for linkage to this region increased to a LOD score of 1.98. Conditional analyses revealed nominally significant interactions between this locus and the regions on chromosomes 10q23.3 (P=.01) and 5q32 (P=.02). These data, derived from one of the largest genome scans undertaken in this condition, confirm that individual susceptibility-gene effects for type 2 diabetes are likely to be modest in size. Taken with genome scans in other populations, they provide both replication of previous evidence indicating the presence of a diabetes-susceptibility locus on chromosome 1q24-25 and support for the existence of additional loci on chromosomes 5, 8, and 10. These data should accelerate positional cloning efforts in these regions of interest.
Society for Endocrinology BES 2008 | 2008
Thomas Barber; Stephen J. Golding; Christopher Alvey; John Wass; Fredrik Karpe; Stephen Franks; Mark I. McCarthy
Archive | 2017
Paul Elliott; John Campbell Chambers; Weihua Zhang; Robert Clarke; Jemma C. Hopewell; John F. Peden; Jeanette Erdmann; Peter S. Braund; James C. Engert; Derrick Bennett; Lachlan Coin; Deborah Ashby; Ioanna Tzoulaki; Ian J. Brown; Shahrul Mt-Isa; Mark I. McCarthy; Leena Peltonen; Nelson B. Freimer; Martin Farrall; Aimo Ruokonen; Anders Hamsten; Noha Lim; Philippe Froguel; Dawn Waterworth; Peter Vollenweider; Waeber G
Archive | 2014
Cecilia M. Lindgren; Mark I. McCarthy
WOS | 2013
Reedik Mägi; Momoko Horikoshi; Ida Surakka; Steven Wiltshire; Antti-Pekka Sarin; Anubha Mahajan; Letizia Marullo; Teresa Ferreira; Sara Hägg; Janina S. Ried; Thomas W. Winkler; Gudmar Thorleifsson; Natalia Tšernikova; T. Esko; Christina Willenborg; Christopher P. Nelson; Marian Beekman; Sara M. Willems; Mark I. McCarthy; Andrew P. Morris; Cecilia M. Lindgren; Samuli Ripatti; Inga Prokopenko
Diabetologia | 2013
V. Lagou; R. Maegi; Ida Surakka; Antti-Pekka Sarin; Momoko Horikoshi; Gudmar Thorleifsson; Sara Hagg; Marian Beekman; C. Ladenvall; J. J Hottenga; Janina S. Ried; Mark I. McCarthy; Andrew P. Morris; Samuli Ripatti; Inga Prokopenko
Archive | 2010
Joshua C. Randall; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Lei Qi; Reedik Mägi; Elizabeth K. Speliotes; Iris M. Heid; Thomas W. Winkler; Themistocles L. Assimes; Anne U. Jackson; M. Carola Zillikens; Tamara B. Harris; L. Adrienne Cupples; Ines Barroso; Ruth J. F. Loos; Karen L. Mohlke; Caroline S. Fox; Mark I. McCarthy; Cecilia M. Lindgren
Archive | 2009
Joshua C. Randall; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Lei Qi; Reedik Mägi; Elizabeth K. Speliotes; Iris M. Heid; Thomas W. Winkler; Themistocles L. Assimes; Anne U. Jackson; M. Carola Zillikens; Tamara B. Harris; L. Adrienne Cupples; Ines Barroso; Ruth J. F. Loos; Karen L. Mohlke; Caroline S. Fox; Mark I. McCarthy; Cecilia M. Lindgren
Society for Endocrinology BES 2008 | 2008
Thomas Barber; Amanda J. Bennett; Christopher J. Groves; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Anna-Liisa Hartikainen; Paul Elliott; Cecilia M. Lindgren; Rachel M. Freathy; Kirsten Koch; Willem H. Ouwehand; Fredrik Karpe; Gerard S. Conway; John Wass; Marjo-Riitta Jarvelin; Stephen Franks; Mark I. McCarthy
Archive | 2008
Nicholas Timpson; Pauline M Emmett; Timothy M. Frayling; Imogen Rogers; Andrew T. Hattersley; Mark I. McCarthy; George Davey Smith