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Dive into the research topics where Mark I. McCarthy is active.

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Featured researches published by Mark I. McCarthy.


American Journal of Human Genetics | 2001

A Genomewide Scan for Loci Predisposing to Type 2 Diabetes in a U.K. Population (The Diabetes UK Warren 2 Repository): Analysis of 573 Pedigrees Provides Independent Replication of a Susceptibility Locus on Chromosome 1q

Steven Wiltshire; Andrew T. Hattersley; Graham A. Hitman; M. Walker; Jonathan C. Levy; Mike Sampson; Stephen O’Rahilly; Timothy M. Frayling; John I. Bell; G. Mark Lathrop; Amanda J. Bennett; Ranjit Dhillon; C Fletcher; Christopher J. Groves; Elizabeth Jones; Philip Prestwich; Nikol Simecek; Pamidighantam V. Subba Rao; Marie Wishart; Richard Foxon; Simon L. Howell; Damian Smedley; Lon R. Cardon; Stephan Menzel; Mark I. McCarthy

Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if current therapeutic and preventative options are to be extended. To identify diabetes-susceptibility genes, we have completed a primary (418-marker, 9-cM) autosomal-genome scan of 743 sib pairs (573 pedigrees) with type 2 diabetes who are from the Diabetes UK Warren 2 repository. Nonparametric linkage analysis of the entire data set identified seven regions showing evidence for linkage, with allele-sharing LOD scores > or =1.18 (P< or =.01). The strongest evidence was seen on chromosomes 8p21-22 (near D8S258 [LOD score 2.55]) and 10q23.3 (near D10S1765 [LOD score 1.99]), both coinciding with regions identified in previous scans in European subjects. This was also true of two lesser regions identified, on chromosomes 5q13 (D5S647 [LOD score 1.22] and 5q32 (D5S436 [LOD score 1.22]). Loci on 7p15.3 (LOD score 1.31) and 8q24.2 (LOD score 1.41) are novel. The final region showing evidence for linkage, on chromosome 1q24-25 (near D1S218 [LOD score 1.50]), colocalizes with evidence for linkage to diabetes found in Utah, French, and Pima families and in the GK rat. After dense-map genotyping (mean marker spacing 4.4 cM), evidence for linkage to this region increased to a LOD score of 1.98. Conditional analyses revealed nominally significant interactions between this locus and the regions on chromosomes 10q23.3 (P=.01) and 5q32 (P=.02). These data, derived from one of the largest genome scans undertaken in this condition, confirm that individual susceptibility-gene effects for type 2 diabetes are likely to be modest in size. Taken with genome scans in other populations, they provide both replication of previous evidence indicating the presence of a diabetes-susceptibility locus on chromosome 1q24-25 and support for the existence of additional loci on chromosomes 5, 8, and 10. These data should accelerate positional cloning efforts in these regions of interest.


Society for Endocrinology BES 2008 | 2008

Global adiposity rather than abnormal regional fat distribution characterises women with polycystic ovary syndrome

Thomas Barber; Stephen J. Golding; Christopher Alvey; John Wass; Fredrik Karpe; Stephen Franks; Mark I. McCarthy


Archive | 2017

GeneticLociAssociatedWithC-ReactiveProtein Levels and Risk of Coronary Heart Disease

Paul Elliott; John Campbell Chambers; Weihua Zhang; Robert Clarke; Jemma C. Hopewell; John F. Peden; Jeanette Erdmann; Peter S. Braund; James C. Engert; Derrick Bennett; Lachlan Coin; Deborah Ashby; Ioanna Tzoulaki; Ian J. Brown; Shahrul Mt-Isa; Mark I. McCarthy; Leena Peltonen; Nelson B. Freimer; Martin Farrall; Aimo Ruokonen; Anders Hamsten; Noha Lim; Philippe Froguel; Dawn Waterworth; Peter Vollenweider; Waeber G


Archive | 2014

Comprehensive assessment of the role of DNA methylation in obesity and type 2 diabetes

Cecilia M. Lindgren; Mark I. McCarthy


WOS | 2013

Large-scale Genome-wide Association Meta-analysis Using Imputation from 2188-haplotype 1000 Genomes Reference Panel Identifies Novel Susceptibility Loci for Anthropometric and Glycemic Traits

Reedik Mägi; Momoko Horikoshi; Ida Surakka; Steven Wiltshire; Antti-Pekka Sarin; Anubha Mahajan; Letizia Marullo; Teresa Ferreira; Sara Hägg; Janina S. Ried; Thomas W. Winkler; Gudmar Thorleifsson; Natalia Tšernikova; T. Esko; Christina Willenborg; Christopher P. Nelson; Marian Beekman; Sara M. Willems; Mark I. McCarthy; Andrew P. Morris; Cecilia M. Lindgren; Samuli Ripatti; Inga Prokopenko


Diabetologia | 2013

Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits

V. Lagou; R. Maegi; Ida Surakka; Antti-Pekka Sarin; Momoko Horikoshi; Gudmar Thorleifsson; Sara Hagg; Marian Beekman; C. Ladenvall; J. J Hottenga; Janina S. Ried; Mark I. McCarthy; Andrew P. Morris; Samuli Ripatti; Inga Prokopenko


Archive | 2010

Genome-wide meta analysis of gender heterogeneity identifies sexually dimorphic variants associated

Joshua C. Randall; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Lei Qi; Reedik Mägi; Elizabeth K. Speliotes; Iris M. Heid; Thomas W. Winkler; Themistocles L. Assimes; Anne U. Jackson; M. Carola Zillikens; Tamara B. Harris; L. Adrienne Cupples; Ines Barroso; Ruth J. F. Loos; Karen L. Mohlke; Caroline S. Fox; Mark I. McCarthy; Cecilia M. Lindgren


Archive | 2009

Genome-wide association meta-analysis of waist-to-hip ratio (WHR) across 35 studies comprising over

Joshua C. Randall; Valgerdur Steinthorsdottir; Gudmar Thorleifsson; Lei Qi; Reedik Mägi; Elizabeth K. Speliotes; Iris M. Heid; Thomas W. Winkler; Themistocles L. Assimes; Anne U. Jackson; M. Carola Zillikens; Tamara B. Harris; L. Adrienne Cupples; Ines Barroso; Ruth J. F. Loos; Karen L. Mohlke; Caroline S. Fox; Mark I. McCarthy; Cecilia M. Lindgren


Society for Endocrinology BES 2008 | 2008

Association of variants within the fat mass and obesity-associated (FTO) gene and polycystic ovary syndrome

Thomas Barber; Amanda J. Bennett; Christopher J. Groves; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Anna-Liisa Hartikainen; Paul Elliott; Cecilia M. Lindgren; Rachel M. Freathy; Kirsten Koch; Willem H. Ouwehand; Fredrik Karpe; Gerard S. Conway; John Wass; Marjo-Riitta Jarvelin; Stephen Franks; Mark I. McCarthy


Archive | 2008

The fat mass- and obesity-associated locus and dietary intake in children 1-3

Nicholas Timpson; Pauline M Emmett; Timothy M. Frayling; Imogen Rogers; Andrew T. Hattersley; Mark I. McCarthy; George Davey Smith

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Aimo Ruokonen

Oulu University Hospital

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Steven Wiltshire

University of Western Australia

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