Mark P. Kreuzer

Unidirectional Emission of a Quantum Dot Coupled to a Nanoantenna

Directed Emission The atomlike features of quantum dots—the discrete energy levels and subsequent emission of light at discrete wavelengths—make them key building blocks in optoelectronic circuits and optical communication. However, the emitted light tends to be omnidirectional, which limits applications that require accurate transmission between sender and receiver. Curto et al. (p. 930; see the Perspective by Giessen and Lippitz) have designed an optical antenna, a shrunk-down version of the Yagi-Uda design used in microwave and radio communication, and show that coupling the quantum dot to the antenna provides control over the direction of the emitted light. An antenna designed for optical wavelengths is used to control the direction of the light emitted from a quantum dot. Nanoscale quantum emitters are key elements in quantum optics and sensing. However, efficient optical excitation and detection of such emitters involves large solid angles because their interaction with freely propagating light is omnidirectional. Here, we present unidirectional emission of a single emitter by coupling to a nanofabricated Yagi-Uda antenna. A quantum dot is placed in the near field of the antenna so that it drives the resonant feed element of the antenna. The resulting quantum-dot luminescence is strongly polarized and highly directed into a narrow forward angular cone. The directionality of the quantum dot can be controlled by tuning the antenna dimensions. Our results show the potential of optical antennas to communicate energy to, from, and between nano-emitters.

Plasmon near-field coupling in metal dimers as a step toward single-molecule sensing.

In this study, we report on ultrasensitive protein detection with lithographically prepared plasmonic nanostructures. We have engineered optical nanosensors by the combined approach of negative resist, electron beam lithography, and reactive ion etching to form highly reproducible arrays of gold dimers in which the near-field coupling in their subwavelength gap enables for scaling the sensing volume down to the single-protein scale. In good agreement with recent theoretical predictions, the dimer geometry offers enhanced sensitivity compared to isolated particles for the detection of both small organic molecules and proteins. Beyond, by exploiting size exclusion, we are capable of monitoring the number of proteins able to bind across the gap region through the precise engineering of the structures coupled to the selective binding of a surface-assembled monolayer and covalent attachment of the protein.

Mapping Intracellular Temperature Using Green Fluorescent Protein

Heat is of fundamental importance in many cellular processes such as cell metabolism, cell division and gene expression. (1-3) Accurate and noninvasive monitoring of temperature changes in individual cells could thus help clarify intricate cellular processes and develop new applications in biology and medicine. Here we report the use of green fluorescent proteins (GFP) as thermal nanoprobes suited for intracellular temperature mapping. Temperature probing is achieved by monitoring the fluorescence polarization anisotropy of GFP. The method is tested on GFP-transfected HeLa and U-87 MG cancer cell lines where we monitored the heat delivery by photothermal heating of gold nanorods surrounding the cells. A spatial resolution of 300 nm and a temperature accuracy of about 0.4 °C are achieved. Benefiting from its full compatibility with widely used GFP-transfected cells, this approach provides a noninvasive tool for fundamental and applied research in areas ranging from molecular biology to therapeutic and diagnostic studies.

LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum

Label-free biosensing based on metallic nanoparticles supporting localized surface plasmon resonances (LSPR) has recently received growing interest (Anker, J. N., et al. Nat. Mater. 2008, 7, 442-453). Besides its competitive sensitivity (Yonzon, C. R., et al. J. Am. Chem. Soc. 2004, 126, 12669-12676; Svendendahl, M., et al. Nano Lett. 2009, 9, 4428-4433) when compared to the surface plasmon resonance (SPR) approach based on extended metal films, LSPR biosensing features a high-end miniaturization potential and a significant reduction of the interrogation device bulkiness, positioning itself as a promising candidate for point-of-care diagnostic and field applications. Here, we present the first, paralleled LSPR lab-on-a-chip realization that goes well beyond the state-of-the-art, by uniting the latest advances in plasmonics, nanofabrication, microfluidics, and surface chemistry. Our system offers parallel, real-time inspection of 32 sensing sites distributed across 8 independent microfluidic channels with very high reproducibility/repeatability. This enables us to test various sensing strategies for the detection of biomolecules. In particular we demonstrate the fast detection of relevant cancer biomarkers (human alpha-feto-protein and prostate specific antigen) down to concentrations of 500 pg/mL in a complex matrix consisting of 50% human serum.

Photonic crystal fiber interferometer for chemical vapor detection with high sensitivity.

We report an in-reflection photonic crystal fiber (PCF) interferometer which exhibits high sensitivity to different volatile organic compounds (VOCs), without the need of any permeable material. The interferometer is compact, robust, and consists of a stub of PCF spliced to standard optical fiber. In the splice the voids of the PCF are fully collapsed, thus allowing the excitation and recombination of two core modes. The device reflection spectrum exhibits sinusoidal interference pattern which shifts differently when the voids of the PCF are infiltrated with VOC molecules. The volume of voids responsible for the shift is less than 600 picoliters whereas the detectable levels are in the nanomole range.

Multipolar radiation of quantum emitters with nanowire optical antennas

Multipolar transitions other than electric dipoles are generally too weak to be observed at optical frequencies in single quantum emitters. For example, fluorescent molecules and quantum dots have dimensions much smaller than the wavelength of light and therefore emit predominantly as electric dipoles. Here we demonstrate controlled emission of a quantum dot into multipolar radiation through selective coupling to a linear nanowire antenna. The antenna resonance tailors the interaction of the quantum dot with light, effectively creating a hybrid nanoscale source beyond the simple Hertz dipole. Our findings establish a basis for the controlled driving of fundamental modes in nanoantennas and metamaterials, for the understanding of the coupling of quantum emitters to nanophotonic devices such as waveguides and nanolasers, and for the development of innovative quantum nano-optics components with properties not found in nature.

Excitation Enhancement of a Quantum Dot Coupled to a Plasmonic Antenna

Plasmonic antennas are key elements to control the luminescence of quantum emitters. However, the antennas influence is often hidden by quenching losses. Here, the luminescence of a quantum dot coupled to a gold dimer antenna is investigated. Detailed analysis of the multiply excited states quantifies the antennas influence on the excitation intensity and the luminescence quantum yield separately.

Photonic crystal fiber microtaper supporting two selective higher-order modes with high sensitivity to gas molecules

A photonic crystal fiber consisting of three rings of air holes was tapered down to 3–5μm. The voids of the fiber were collapsed so a solid microtaper was formed. In this microtaper two selective higher-order modes propagate and interfere. This makes the transmission of the taper to exhibit a sinusoidal pattern with subnanometric width fringes. It was found that the device was highly sensitive to gas molecules. The latter is attributed to surface refractive index changes, number of molecules enveloping the taper, and high sensitivity of the modes participating in the interference.

Biosensing: Plasmons offer a helping hand

Arrays of metallic nanostructures allow chiral biomolecules to be detected and characterized with increased sensitivity.

Detection of plasmon-enhanced luminescence fields from an optically manipulated pair of partially metal covered dielectric spheres

Using optical tweezers combined with luminescence measurements we detected the optical field around two optically trapped silica microspheres partially covered by metal. By monitoring the luminescence of rhodamine 6G we were able to observe an increase of the local field intensity owing to the coupling of the local surface plasmons at the surfaces of two spheres.