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Dive into the research topics where Mark R. Kennedy is active.

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Featured researches published by Mark R. Kennedy.


ASME 2003 International Mechanical Engineering Congress and Exposition | 2003

A Reagent Dispense Verification System for a Fully-Automated, Amplified Nucleic Acid Diagnostic Instrument

Mark R. Kennedy; Raul Pacheco; John Van Doorn; Rommel M. Hipolito

Amplified nucleic acid diagnostics have brought extraordinarily powerful biochemical tools to bear on screening for and diagnosing infectious diseases. For example, current assays routinely permit the detection of 100 particles of human immunodeficiency virus or hepatitis C virus in one mL of blood. Such assays are used for screening the blood supply. To permit reliable automation of these complex and sensitive assays fluidic measurement and control systems are required. Such controls are needed to ensure that correct reagents are reliably dispensed into the reaction tubes. In this paper we will review the design and performance of a prototype Reagent Dispense Verification system for use on a fully-automated, amplified, nucleic acid diagnostic instrument. The system design utilizes hydraulic pressure drop and conductivity as the primary dispense parameters. In addition to the dispense verification function, the system provides a capacitive liquid level sensing function. The pipetting probe design and manufacturing process provide two conductive surfaces separated by an electrically insulating gap over which conductivity is measured. Hydraulic pressure drop is measured with an in-line, flow-through pressure transducer. The time-varying pressure and conductivity signals are used to classify each dispense operation as acceptable or not. Overall system performance data are presented demonstrating the viability of the design.Copyright


Archive | 2003

Method for obtaining the contents of a fluid-holding vessel

Mordi I. Iheme; Daniel L. Kacian; Mark R. Kennedy


Archive | 2004

Clamp and method of making same

Mark R. Kennedy; Byron J. Knight


Archive | 2009

Method for removing a fluid substance from a closed system

Daniel L. Kacian; Mark R. Kennedy; Nick M. Carter


Archive | 2006

Parametric calibration method

James M. Carrick; Mark R. Kennedy; Jeffrey D. Chismar


Archive | 2007

Method for accessing the contents of a closed collection device with a modified pipette tip

Mordi I. Iheme; Daniel L. Kacian; Mark R. Kennedy; Gus G. Tseo; Bruce W. Anderson; Kathleen A. Dickey; Nick M. Carter


Archive | 2004

Method for transferring a substance to or from a closed system

Daniel L. Kacian; Mark R. Kennedy; Nick M. Carter


Archive | 2004

Elastic clamp and syringe pump comprising the clamp

Mark R. Kennedy; Byron J. Knight


Archive | 2000

Fluid transfer device for use with penetrable cap

Bruce W. Anderson; Mordi I. Iheme; Nick M. Carter; Daniel L. Kacian; Janice J. Clymer; James P. Light; Gus G. Tseo; Mark R. Kennedy


Archive | 2008

Penetrable cap having rib structures

Mordi I. Iheme; Daniel L. Kacian; Mark R. Kennedy

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Gus G. Tseo

Gen-Probe Incorporated

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