Mark R. Waldman

Meditation Effects on Cognitive Function and Cerebral Blood Flow In Subjects with Memory Loss: A Preliminary Study

This preliminary study determined if subjects with memory loss problems demonstrate changes in memory and cerebral blood flow (CBF) after a simple 8-week meditation program. Fourteen subjects with memory problems had an IV inserted and were injected with 250 MBq of Tc-99m ECD while listening to a neutral stimulus CD. They then underwent a pre-program baseline SPECT scan. Then subjects were guided through their first meditation session with a CD, during which they received an injection of 925 MBq ECD, and underwent a pre-program meditation scan. Subjects completed an 8-week meditation program and underwent the same scanning protocol resulting in a post-program baseline and meditation scan. A region of interest (ROI) template obtained counts in each ROI normalized to whole brain to provide a CBF ratio. Baseline and meditation scans and neuropsychological testing were compared before and after the program. The meditation program resulted in significant increases (p< 0.05) in baseline CBF ratios in the prefrontal, superior frontal, and superior parietal cortices. Scores on neuropsychological tests of verbal fluency, Trails B, and logical memory showed improvements after training. This preliminary study evaluated whether an 8-week meditation program resulted in improvements in neuropsychological function and differences in CBF in subjects with memory loss. While the findings are encouraging, there are a number of limitations that can be addressed in future studies with more participants and more detailed analyses.

Cerebral blood flow differences between long-term meditators and non-meditators.

We have studied a number of long-term meditators in previous studies. The purpose of this study was to determine if there are differences in baseline brain function of experienced meditators compared to non-meditators. All subjects were recruited as part of an ongoing study of different meditation practices. We evaluated 12 advanced meditators and 14 non-meditators with cerebral blood flow (CBF) SPECT imaging at rest. Images were analyzed with both region of interest and statistical parametric mapping. The CBF of long-term meditators was significantly higher (p<.05) compared to non-meditators in the prefrontal cortex, parietal cortex, thalamus, putamen, caudate, and midbrain. There was also a significant difference in the thalamic laterality with long-term meditators having greater asymmetry. The observed changes associated with long-term meditation appear in structures that underlie the attention network and also those that relate to emotion and autonomic function.

Effects of an 8-week meditation program on mood and anxiety in patients with memory loss.

BACKGROUND This study assesses changes in mood and anxiety in a cohort of subjects with memory loss who participated in an 8-week Kirtan Kriya meditation program. Perceived spirituality also was assessed. Previous reports from this cohort showed changes in cognitive function and cerebral blood flow (CBF). The purpose of this analysis was to assess outcome measures of mood and affect, and also spirituality, and to determine whether or not results correlated with changes in CBF. METHODS Fifteen (15) subjects (mean age 62±7 years) with memory problems were enrolled in an 8-week meditation program. Before and after the 8-week meditation, subjects were given a battery of neuropsychologic tests as well as measures of mood, anxiety, and spirituality. In addition, they underwent single photon emission computed tomography scans before and after the program. A region-of-interest template obtained counts in several brain structures that could also be compared to the results from the affect and spirituality measures. RESULTS The meditation training program resulted in notable improvement trends in mood, anxiety, tension, and fatigue, with some parameters reaching statistical significance. All major trends correlated with changes in CBF. There were nonsignificant trends in spirituality scores that did not correlate with changes in CBF. CONCLUSIONS An 8-week, 12 minute a day meditation program in patients with memory loss was associated with positive changes in mood, anxiety, and other neuropsychologic parameters, and these changes correlated with changes in CBF. A larger-scale study is needed to confirm these findings and better elucidate mechanisms of change.

The noetic quality: A multimethod exploratory study.

Religious, spiritual, and mystical experiences (RSMEs) are often described as having a noetic quality, or the compelling sense that the experience feels “real.” In this exploratory, multimethod study, 701 participants completed questions about the subjective qualities of their RMSEs, reported the impact of their RSMEs on various life domains, and provided written descriptions of their experiences for quantitative linguistic analysis. The majority of participants (69%) reported that their RSMEs felt “more real than their usual sense of reality.” This quality of realness was associated with positive self-reported impacts on family life (r = .16), health (r = .22), sense of purpose (r = .29), spirituality (r = .30), and reduced fear of death (r = .24). Participants who reported experiences as feeling more real used more language referring to connection, a greater whole, and certainty (“love,” “all,” “and,” “everything”) and fewer first-person pronouns, cognitive processes, and tentativeness (“I,” “me,” “think,” “probably”). These findings provide insight into the noetic quality, as well as the psychological characteristics that may underlie the noetic quality of RSMEs.

Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: a preliminary study

Meditation has long been defined as a potential technique for improving memory and lowering levels of stress, depression, and anxiety. Until now, there have been a few treatment options for patients with early cognitive impairment. Several medications and vaccine trials are underway. In one of the studies conducted Lutz and their team showed that expert meditators were able to induce changes in their brain activity during meditation with the help of electroencephalography. doi : 10.5214/ans.0972.7531.12190207

Religious Experience: Psychology and Neurology

This article reviews the current information regarding the neurological and psychological correlates of religious and spiritual experiences. Such experiences appear to involve a number of different brain structures including the frontal and parietal lobes, the limbic structures, and the hypothalamus. In addition, neurotransmitters including serotonin, dopamine, endorphins, and glutamate may also help mediate such phenomena. The result appears to be a complex set of neural pathways that are activated in different ways, depending on the particular experience. Issues and implications for future investigations are also considered.