Mark S. Nelson

Allele Frequencies for Fourteen STR Loci of the PowerPlex™ 1.1 and 2.1 Multiplex Systems and Penta D Locus In Caucasians, African-Americans, Hospanics, and Other Populations of the United States of America and Brazil

Allele Frequencies for Fourteen STR Loci of the PowerPlex™ 1.1 and 2.1 Multiplex Systems and Penta D Locus In Caucasians, African-Americans, Hospanics, and Other Populations of the United States of America and Brazil

A Computer-Assisted Population Frequency Study of 14 Polymorphic Blood Grouping Systems in North Carolina

Results of a population frequency study conducted on 14 polymorphic blood grouping systems in the North Carolina white and black populations are reported. A microcomputer program has been developed to facilitate the handling and storage of the large volume of data generated during the two years it took to complete this study. This computer program was also designed to calculate the combined phenotypic frequency for a given set of blood types.

A Feasibility Study of Human Leukocyte Antigen (HLA) Typing for Dried Bloodstains

This paper constitutes a feasibility report on the use of the human leukocyte antigen (HLA) system for the typing of dried bloodstains. Antigens tested include the HLA-A2, A3, A10, B7, B8, and B14 alleles. An aging study conducted on A3 positive bloodstains showed that HLA-A3 could be reliably detected on bloodstains stored up to 30 days at 22 degrees C. Unlike most earlier reports on HLA typing of bloodstains, no cross-reactivity problems were detected with the antisera used in this study. In addition to the successful typing of bloodstains, we were also able to type fresh, neat seminal and saliva stains in the A2 and A10 antigenic systems.

Detection of the Rare PGM13Allele. Further Biochemical and Genetic Characterization of the PGM13Isozymes

A family possessing the rare PGM1(3) allele has been found in North Carolina, and criteria for the electrophoretic separation and accurate typing of the PGM1(3) isozymes are outlined. The PGM1(3) isozymes detected proved to be useful in helping to determine parentage in an incest investigation. The pattern of segregation of the PGM1(3) allele in four generations of this family and thermostability studies on the PGM1(3) isozymes are presented.