Mark W. Geisler
University of California, San Diego
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Featured researches published by Mark W. Geisler.
Journal of Clinical and Experimental Neuropsychology | 1995
Elizabeth A. Gaudino; Mark W. Geisler; Nancy K. Squires
The Trail Making Test (TMT) is primarily a test of motor speed and visual attention. In Trail Making, Part A, the subjects task is to quickly draw lines on a page connecting 25 consecutive numbers. In Part B, the subject must draw the lines alternating between numbers and letters. To determine what makes Part B harder than Part A, variations of the standard Trail Making Test were assessed. Forty college students (20 male, 20 female) were given four forms of the Trail Making Test. The results show that Trail Making, Part B with just numbers took longer to complete than the standard Part A with numbers. Part B is 56 cm longer and has more visually interfering stimuli than Part A. These results indicate that Part B is more difficult than Part A not only because it is a more difficult cognitive task, but also because of its increased demands in motor speed and visual search.
International Journal of Psychophysiology | 2000
Claire Murphy; Charlie D. Morgan; Mark W. Geisler; Spencer Wetter; James W Covington; Michael D Madowitz; Steven Nordin; John Polich
Unlike the clinical usages of evoked potentials (e.g. brain stem auditory evoked potentials for the assessment of auditory function), normative data for the olfactory event-related potential (OERP) have been unavailable. The principal objective was to establish normative data across the human life span for OERPs with a given set of parameters. Participants were 140 persons from seven age groups (16-19, 20-29, 30-39, 40-49, 50-59, 60-69 and 70-79 years of age), with equal numbers of males and females, screened for nasal health and dementia. The odor stimulus was amyl acetate, presented at nasal temperature in a humidified airstream delivered by an air-dilution olfactometer at a constant flow rate, using a 60-s inter-stimulus interval. OERPs were recorded at Fz, Cz, and Pz electrode sites, amplified and averaged over trials. Amplitudes of the N1/P2 and P3 and latencies of the P2 and P3 were analyzed. Processing speed decreased at a constant rate over decades for the sensory (P2 latency) as well as cognitive (P3 latency) components. Decline in amplitude over decades was also apparent. Normative data will be useful in research on olfactory function and in clinical assessment of olfactory functional status.
Electroencephalography and Clinical Neurophysiology | 1997
Charlie D. Morgan; James W Covington; Mark W. Geisler; John Polich; Claire Murphy
Olfactory event-related potentials (OERPs) were recorded monopolarly at the Fz, Cz, and Pz electrode sites in 16 young adults (8M/8F) and 16 older adults (8M/8F) with inter-stimulus intervals (ISI) of 45, 60 and 90 s using amyl acetate as the odorant stimulus. N1, P2, and N2 peak amplitudes and latencies were measured. Young participants demonstrated significantly shorter peak latencies than older participants. Older males demonstrated significantly smaller peak amplitudes than the other participant groups. Peak amplitudes also increased with longer ISIs for older males. The OERP is compared to traditional olfactory psychophysical testing.
Biological Psychology | 1990
Mark W. Geisler; John Polich
The P300 or P3 component of the event-related brain potential (ERP) was obtained from five groups of 24 young adult subjects, with each group measured at a different time of day (8 a.m., 11 a.m., 2 p.m., 5 p.m., 8 p.m.). An activity-preference questionnaire was used to ensure that an equitable number of morning- and evening-preferring subjects were obtained for each testing time. P3 measures, physiological (body temperature, heart rate, subjective alertness), and cognitive performance (digit span, prose memory, digit symbol) variables were assessed. P3 amplitude and latency were not affected directly by the time of day. However, P3 amplitude was smaller in subjects who had not eaten within 6 hours of testing relative to subjects who had a recent meal, and P3 latency was correlated negatively with body temperature. The findings suggest that although the P3 ERP is not influenced by circadian rhythms, it is related to recency of food intake and physiological factors which change with time of day.
Psychophysiology | 1999
Charlie D. Morgan; Mark W. Geisler; James W Covington; John Polich; Claire Murphy
Olfactory event-related potentials (OERPs) were recorded monopolarly at the Fz, Cz, and Pz electrode sites in 16 young adults and 16 older adults to assess aging effects on the olfactory P3. Amyl acetate was used to elicit the OERPs, with an intertrial interval of 45 s. Young adults produced significantly larger P3 amplitudes and shorter P3 peak latencies than older adults. The olfactory P3 response appears to be sensitive to age-related changes in the olfactory system and may reflect cognitive slowing in the central nervous system.
International Journal of Psychophysiology | 1991
John Polich; Thomas Brock; Mark W. Geisler
The P300 (P3) event-related brain potential (ERP) was elicited with auditory and somatosensory stimuli using an easy discrimination task in two experiments. Experiment 1 manipulated target stimulus probability (0.20 vs. 0.80). Experiment 2 manipulated inter-stimulus interval (2 s vs. 6 s) for both stimulus modalities in different conditions while keeping target probability constant. Probability and inter-stimulus interval had similar effects for auditory and somatosensory stimuli, with lower probability and longer inter-stimulus intervals producing larger P3 amplitudes. No statistically reliable differences in scalp distribution between modalities were obtained, with both modalities producing maximal amplitudes at Pz. The results suggest that auditory and somatosensory stimuli when used in a relatively easy discrimination task yield the same overall P3 values.
International Journal of Psychophysiology | 1999
James W Covington; Mark W. Geisler; John Polich; Claire Murphy
Olfactory event-related potentials (OERPs) were recorded in 14 young and 14 older adults, with odor strength of isoamyl acetate manipulated to assess olfactory stimulus intensity. Young participants produced significantly larger N1/P2, N2/P3 amplitudes and shorter N1, P2 and N2 latencies than older participants. Medium- and high-odor concentrations elicited significantly shorter P2 and N2 latencies than the lowest concentration for both age groups. Odor concentration appears to affect the speed of olfactory stimulus information processing regardless of age.
Physiology & Behavior | 1994
Mark W. Geisler; John Polich
The P3(00) event-related brain potential (ERP) was elicited with visual stimuli using an oddball task in which the subject indicated with a finger tap response the occurrence of a target stimulus that occurred randomly on 20% of the trials and refrained from responding to a standard stimulus. A total of six trial blocks were collected, with an equal number of artifact-free epochs averaged for both stimulus types. P3 amplitude from the target stimuli did not decrease across trial blocks; P3 amplitude from the standard stimuli did decrease across trial blocks. P3 latency from both the target and standard stimuli increased across trial blocks. No changes in amplitude or latency independent of the P3 effects were obtained for the other ERP components with trial block. The results suggest that P3 components elicited by visual stimuli do not readily habituate for actively discriminated target stimuli. The theoretical implications are discussed in the context of previous findings.
Biological Psychology | 1991
John Polich; Mark W. Geisler
The P300 (P3) event-related brain potential (ERP) was elicited with auditory stimuli in four different groups of normal, young adult subjects (n = 20 in each group) whose ERPs were obtained at different times of the year. P3 amplitude was largest during spring and summer and smaller for the subjects who were assessed during fall and winter. P3 latency was not affected reliably by changes in the seasons. Measurement of the daily sunshine present when each subject was recorded indicated that P3 amplitude is influenced by seasonal variation in the available amount of sunshine. These findings suggest that comparison of P3 amplitude across subject groups must take seasonal differences into account.
Journal of Clinical Neurophysiology | 1999
Mark W. Geisler; Christina Schlotfeldt; Christina B. Middleton; Mario F. Dulay; Claire Murphy
Olfactory event-related potentials (OERPs) were evaluated to develop an objective, quantitative assessment of sensory and cognitive olfactory loss following traumatic brain injury (TBI). Subjects included 25 TBI patients and 25 age/gender-matched healthy controls. Following standard clinical evaluation of smell function, TBI patients were divided into three groups: 12 anosmics (loss of smell), 6 hyposmics (reduced smell), and 7 normosmics (normal smell). Cognitive ability was assessed using the Trail Making Test (A and B). OERPs were recorded monopolarly from midline electrode sites using an amyl acetate stimulus with a 60-second interstimulus interval; subjects estimated the magnitude of each odor stimulus. Anosmic TBI patients were also tested with OERPs using ammonia to ensure trigeminal nerve function. Amyl acetate OERPs demonstrated that the sensory N1 and P2 amplitudes and the cognitive P3 amplitudes were absent in the anosmic TBI patients and greatly reduced in the hyposmic and normosmic TBI patients compared to healthy controls. The trigeminal OERPs from the anosmic TBI patients were within normal limits, indicating that the primary olfactory deficits were objectively measured with OERPs. The relationship between the OERPs and neuropsychologic test performance supports the cognitive loss associated with TBI. The present study lends support to the utility of OERPs as an objective tool for measuring sensory and cognitive loss after traumatic brain injury.